CTSB, cathepsin B, 1508

N. diseases: 304; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0406756
Disease: Keratolytic winter erythema
Keratolytic winter erythema 		0.520 Biomarker disease BEFREE CTSB and FDFT1 are excluded as candidates for KWE. 21945151 2012
CUI: C0406756
Disease: Keratolytic winter erythema
Keratolytic winter erythema 		0.520 ChromosomalRearrangement disease ORPHANET In conclusion, KWE in South African and Norwegian families is caused by tandem duplications in a non-coding genomic region containing an active enhancer element for CTSB, resulting in upregulation of this gene in affected individuals. 28457472 2017
CUI: C0406756
Disease: Keratolytic winter erythema
Keratolytic winter erythema 		0.520 GeneticVariation disease BEFREE In conclusion, KWE in South African and Norwegian families is caused by tandem duplications in a non-coding genomic region containing an active enhancer element for CTSB, resulting in upregulation of this gene in affected individuals. 28457472 2017
CUI: C0406756
Disease: Keratolytic winter erythema
Keratolytic winter erythema 		0.520 Biomarker disease CTD_human
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Tumor infiltration with activated cytotoxic T cells, induction of cathepsin B and inducible nitric oxide (NO) synthase (iNOS) expression in tumor-associated microglia/macrophages (TAM), and accumulation of activated TAM in cluster of differentiation (CD) 40 ligand (CD40L)-positive glioblastoma regions was detected. 29244745 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Moreover, ATO significantly increased adhesion of U87MG cells and also diminished transcription of NF-κB down-stream targets involved in cell migration and invasion, including cathepsin B, uPA, MMP-2, MMP-9 and MMP-14 and suppressed proteolytic activity of cathepsin B, MMP-2 and MMP-9, demonstrating a possible mechanism of ATO effect on a well-known signaling in glioblastoma dissemination. 27039805 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway. 27260469 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease CTD_human The regulation of cysteine cathepsins and cystatins in human gliomas. 22287159 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. 15122332 2004
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. 11439329 2001
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE The expression of cathepsin B and X was detected in stromal cells and cancer cells throughout the GBM sections, whereas cathepsin K expression was more restricted to arteriole-rich regions in the GBM sections. 30046941 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease LHGDN Taken together, these results provide evidence that inhibition of cathepsin B expression can suppress glioblastoma-induced neovascularization. 14730346 2004
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease LHGDN Transfection of a plasmid vector-expressing double-stranded RNA (dsRNA) for MMP-9 and cathepsin B significantly inhibited MMP-9 and cathepsin B expression and reduced the invasive behavior of SNB19, glioblastoma cell line in Matrigel and spheroid invasion models. 15122332 2004
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Using mutagenesis, transient transfection and electrophoretic mobility shift assays (EMSAs), we further identified regulatory factors that mediate cathepsin B transcription in U87 human glioblastoma cells. 14669984 2004
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Using RT-PCR (reverse transcription-polymerase chain reaction) and primer extension assays, CTSB mRNA species were found to differ among tissues and between a glioblastoma sample and a cell line derived from it. 7622042 1995
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Furthermore, a marked reduction in microvasculature development was seen in an in vivo dorsal air sac assay of glioblastoma cells with downregulated cathepsin B expression. 14730346 2004
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Here, we investigated the radioresistant role of Cathepsin B (CTSB), one important member of cysteine proteases, in GBM cell lines. 30099343 2018
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Moreover, ATO significantly increased adhesion of U87MG cells and also diminished transcription of NF-κB down-stream targets involved in cell migration and invasion, including cathepsin B, uPA, MMP-2, MMP-9 and MMP-14 and suppressed proteolytic activity of cathepsin B, MMP-2 and MMP-9, demonstrating a possible mechanism of ATO effect on a well-known signaling in glioblastoma dissemination. 27039805 2016
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. 11439329 2001
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway. 27260469 2016
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Using RT-PCR (reverse transcription-polymerase chain reaction) and primer extension assays, CTSB mRNA species were found to differ among tissues and between a glioblastoma sample and a cell line derived from it. 7622042 1995
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE Here, we investigated the radioresistant role of Cathepsin B (CTSB), one important member of cysteine proteases, in GBM cell lines. 30099343 2018
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. 15122332 2004
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease CTD_human The regulation of cysteine cathepsins and cystatins in human gliomas. 22287159 2012
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Using mutagenesis, transient transfection and electrophoretic mobility shift assays (EMSAs), we further identified regulatory factors that mediate cathepsin B transcription in U87 human glioblastoma cells. 14669984 2004