CTSB, cathepsin B, 1508

N. diseases: 304; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0406756
Disease: Keratolytic winter erythema
Keratolytic winter erythema 		0.520 Biomarker disease CTD_human
CUI: C0020458
Disease: Hyperhidrosis disorder
Hyperhidrosis disorder 		0.100 Biomarker phenotype HPO
CUI: C0041834
Disease: Erythema
Erythema 		0.100 Biomarker phenotype HPO
CUI: C0241157
Disease: pustule
pustule 		0.100 Biomarker phenotype HPO
CUI: C1274743
Disease: Hyperhidrosis Palmaris Et Plantaris
Hyperhidrosis Palmaris Et Plantaris 		0.100 Biomarker disease HPO
CUI: C0026848
Disease: Myopathy
Myopathy 		0.300 Biomarker group CTD_human In this report we examine the activities of the lysosomal endoproteinase cathepsin B and its endogenous inhibitor(s) in the red and white skeletal muscles of guinea pigs with nutritional muscular myopathy induced by vitamin E deficiency. 7099197 1982
CUI: C0033687
Disease: Proteinuria
Proteinuria 		0.300 Biomarker phenotype CTD_human Cathepsin B and L in nephron segments of rats with puromycin aminonucleoside nephrosis. 3669494 1987
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.210 AlteredExpression group BEFREE Relative amounts of mRNA for cathepsin B were measured in normal murine liver and three murine tumors, an invasive liver tumor (hepatoma, Hepa cl 9) and two melanoma variants (B16-F1 and B16 amelanotic melanoma, B16a). 2924910 1989
CUI: C0206735
Disease: Melanoma, Amelanotic
Melanoma, Amelanotic 		0.010 AlteredExpression disease BEFREE Relative amounts of mRNA for cathepsin B were measured in normal murine liver and three murine tumors, an invasive liver tumor (hepatoma, Hepa cl 9) and two melanoma variants (B16-F1 and B16 amelanotic melanoma, B16a). 2924910 1989
CUI: C0349515
Disease: Amelanotic Skin Melanoma
Amelanotic Skin Melanoma 		0.010 AlteredExpression disease BEFREE Relative amounts of mRNA for cathepsin B were measured in normal murine liver and three murine tumors, an invasive liver tumor (hepatoma, Hepa cl 9) and two melanoma variants (B16-F1 and B16 amelanotic melanoma, B16a). 2924910 1989
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.020 Biomarker disease BEFREE Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis. 1953821 1991
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE At neutral pH and 24 degrees C, cathepsin B from both normal liver and tumour exhibited a lower Km and a higher kcat./Km than at pH 6.0. 1637335 1992
CUI: C0276496
Disease: Familial Alzheimer Disease (FAD)
Familial Alzheimer Disease (FAD) 		0.010 GeneticVariation disease BEFREE Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease. 8239266 1993
CUI: C0017638
Disease: Glioma
Glioma 		0.300 AlteredExpression disease BEFREE Cathepsin B expression and localization in glioma progression and invasion. 7954439 1994
CUI: C0001126
Disease: Renal tubular acidosis
Renal tubular acidosis 		0.200 Biomarker phenotype RGD Renal tubular cell protein breakdown in uninephrectomized and ammonium chloride-loaded rats. 7873730 1994
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Four full-length cDNA clones coding for preprocathepsin B were isolated from a human gastric adenocarcinoma cDNA library (AGS 1-6-30-1) and analyzed for possible sequence modifications that might be linked to altered intracellular trafficking and secretion of cathepsin B (CTSB) in malignant tumors. 8112600 1994
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE We have accumulated substantial evidence implicating the cysteine protease cathepsin B in human glioma malignancy. 7954439 1994
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE Gelatinase A (MMP-2) and cathepsin B are proteinases which have been proposed to participate in human tumor invasion and metastasis. 7992833 1994
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE However, tumor material is considerably richer in cathepsin B activity than normal material. 8074469 1994
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 AlteredExpression phenotype BEFREE Increased levels of pro-enzyme and active enzyme forms of gelatinase A (MMP-2) and increased cathepsin B activity were localized in regions of tumor invasion as compared with a matched number of normal epithelial cells from the same patient. 7992833 1994
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 Biomarker phenotype BEFREE These data support the hypothesis that cathepsin B plays a role in human glioma progression and invasion. 7954439 1994
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE We have accumulated substantial evidence implicating the cysteine protease cathepsin B in human glioma malignancy. 7954439 1994
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.040 Biomarker group BEFREE Qualitative differences in the pattern of cathepsin B species between tumor and corresponding normal material or between different histologies of lung tumors were not found. 8074469 1994
CUI: C0006267
Disease: Bronchiectasis
Bronchiectasis 		0.010 Biomarker disease BEFREE Although the lysosomal cysteine proteinase cathepsin B is alkaline pH-labile, active, stable high molecular mass forms have been reported previously from the culture medium of human and murine mammary tumor explants and the sputum of patients with purulent bronchiectasis. 8175724 1994
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Using RT-PCR (reverse transcription-polymerase chain reaction) and primer extension assays, CTSB mRNA species were found to differ among tissues and between a glioblastoma sample and a cell line derived from it. 7622042 1995