|
Acromegaly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study was planned to investigate an association of serum levels of matrix metalloproteinase-2, matrix metalloproteinase-9, and cathepsin B with disease activity in acromegaly patients.
|
28332074 |
2017 |
|
Acute Coronary Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we aimed to evaluate the effect of the dose of rosuvastatin on NLRP3 and cathepsin-B expression in peripheral blood monocytes in patients with acute coronary syndrome.
|
25946654 |
2015 |
|
Acute monocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CTSL and CTSB protease activity and their mRNA expression were significantly higher in AML patients compared to controls (p ≤ 0.001).
|
20567828 |
2010 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These experiments provide the first conclusive evidence to our knowledge that cathepsin B plays a role in intrapancreatic trypsinogen activation and the onset of acute pancreatitis.
|
10995788 |
2000 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
GATA-4, a member of a zinc finger transcription factor family, was confirmed to be amplified and overexpressed in esophageal adenocarcinomas and was localized within <0.5 kb from CTSB.
|
10728696 |
2000 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Northern blot analysis showed overexpression of CTSB and FDFT1 mRNA in all six of the amplified esophageal adenocarcinomas analyzed.
|
9770500 |
1998 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail.
|
30818851 |
2019 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have found a novel amplicon at 8p22-23 that results in CTSB overexpression in esophageal adenocarcinoma.
|
9770500 |
1998 |
|
Adenocarcinoma of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The VV genotype of the CTSB L26V SNP may indicate an increased risk for PCa and less differentiated cancer (higher Gleason score).
|
19930869 |
2010 |
|
Adenocarcinoma of rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
It appears that the pericellular localization of cathepsin B, also observed in colon and rectum adenocarcinoma tissue samples, plays a key role in its function.
|
30818851 |
2019 |
|
Adenoid Cystic Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma.
|
30968153 |
2019 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Results show that mRNA and activated levels of cathepsin B were both increased in human adenomas and in CRCs of all stages.
|
25808857 |
2016 |
|
Adult Glioblastoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells.
|
11439329 |
2001 |
|
Adult Glioblastoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Tumor infiltration with activated cytotoxic T cells, induction of cathepsin B and inducible nitric oxide (NO) synthase (iNOS) expression in tumor-associated microglia/macrophages (TAM), and accumulation of activated TAM in cluster of differentiation (CD) 40 ligand (CD40L)-positive glioblastoma regions was detected.
|
29244745 |
2017 |
|
Adult Glioblastoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Using mutagenesis, transient transfection and electrophoretic mobility shift assays (EMSAs), we further identified regulatory factors that mediate cathepsin B transcription in U87 human glioblastoma cells.
|
14669984 |
2004 |
|
Adult Glioblastoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.
|
15122332 |
2004 |
|
Adult Glioblastoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Moreover, ATO significantly increased adhesion of U87MG cells and also diminished transcription of NF-κB down-stream targets involved in cell migration and invasion, including cathepsin B, uPA, MMP-2, MMP-9 and MMP-14 and suppressed proteolytic activity of cathepsin B, MMP-2 and MMP-9, demonstrating a possible mechanism of ATO effect on a well-known signaling in glioblastoma dissemination.
|
27039805 |
2016 |
|
Adult Glioblastoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Using RT-PCR (reverse transcription-polymerase chain reaction) and primer extension assays, CTSB mRNA species were found to differ among tissues and between a glioblastoma sample and a cell line derived from it.
|
7622042 |
1995 |
|
Adult Glioblastoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, a marked reduction in microvasculature development was seen in an in vivo dorsal air sac assay of glioblastoma cells with downregulated cathepsin B expression.
|
14730346 |
2004 |
|
Adult Glioblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway.
|
27260469 |
2016 |
|
Adult Glioblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Cathepsin B contributes to radioresistance by enhancing homologous recombination in glioblastoma.
|
30099343 |
2018 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that ADCX, a natural cycloartane triterpenoid extracted from the traditional Chinese medicine (TCM) source Cimicifugae rhizoma (Shengma), impaired autophagic degradation by suppressing lysosomal cathepsin B (CTSB) expression in multidrug-resistant liver cancer HepG2/ADM cells, thereby leading to autophagic flux inhibition.
|
29074104 |
2017 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additional work further confirmed CDK6, RICTOR, and CTSB (cathepsin B) as targets of miR-218 and examined the functional role of one of these targets, CDK6, in medulloblastoma.
|
23212916 |
2013 |
|
Adult Meningioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
As to the second aim, the possible association of cathepsin B along with selected molecular markers, cathepsin L, and endogenous cysteine protease inhibitors (stefins A and B and cystatin C) with meningioma malignancy was determined using enzyme-linked immunosorbent assays in tumor homogenates.
|
19747051 |
2010 |
|
Adult Meningioma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The migration and invasion of meningioma cells were decreased after treatment with single or bicistronic siRNA constructs for cathepsin B and MMP-9 compared to controls and vector controls.
|
17912429 |
2007 |