CTSB, cathepsin B, 1508

N. diseases: 304; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0406756
Disease: Keratolytic winter erythema
Keratolytic winter erythema 		0.520 Biomarker disease CTD_human
CUI: C0020458
Disease: Hyperhidrosis disorder
Hyperhidrosis disorder 		0.100 Biomarker phenotype HPO
CUI: C0041834
Disease: Erythema
Erythema 		0.100 Biomarker phenotype HPO
CUI: C0241157
Disease: pustule
pustule 		0.100 Biomarker phenotype HPO
CUI: C1274743
Disease: Hyperhidrosis Palmaris Et Plantaris
Hyperhidrosis Palmaris Et Plantaris 		0.100 Biomarker disease HPO
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE At neutral pH and 24 degrees C, cathepsin B from both normal liver and tumour exhibited a lower Km and a higher kcat./Km than at pH 6.0. 1637335 1992
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.020 Biomarker disease BEFREE Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis. 1953821 1991
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.210 AlteredExpression group BEFREE Relative amounts of mRNA for cathepsin B were measured in normal murine liver and three murine tumors, an invasive liver tumor (hepatoma, Hepa cl 9) and two melanoma variants (B16-F1 and B16 amelanotic melanoma, B16a). 2924910 1989
CUI: C0206735
Disease: Melanoma, Amelanotic
Melanoma, Amelanotic 		0.010 AlteredExpression disease BEFREE Relative amounts of mRNA for cathepsin B were measured in normal murine liver and three murine tumors, an invasive liver tumor (hepatoma, Hepa cl 9) and two melanoma variants (B16-F1 and B16 amelanotic melanoma, B16a). 2924910 1989
CUI: C0349515
Disease: Amelanotic Skin Melanoma
Amelanotic Skin Melanoma 		0.010 AlteredExpression disease BEFREE Relative amounts of mRNA for cathepsin B were measured in normal murine liver and three murine tumors, an invasive liver tumor (hepatoma, Hepa cl 9) and two melanoma variants (B16-F1 and B16 amelanotic melanoma, B16a). 2924910 1989
CUI: C0033687
Disease: Proteinuria
Proteinuria 		0.300 Biomarker phenotype CTD_human Cathepsin B and L in nephron segments of rats with puromycin aminonucleoside nephrosis. 3669494 1987
CUI: C0026848
Disease: Myopathy
Myopathy 		0.300 Biomarker group CTD_human In this report we examine the activities of the lysosomal endoproteinase cathepsin B and its endogenous inhibitor(s) in the red and white skeletal muscles of guinea pigs with nutritional muscular myopathy induced by vitamin E deficiency. 7099197 1982
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Using RT-PCR (reverse transcription-polymerase chain reaction) and primer extension assays, CTSB mRNA species were found to differ among tissues and between a glioblastoma sample and a cell line derived from it. 7622042 1995
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Using RT-PCR (reverse transcription-polymerase chain reaction) and primer extension assays, CTSB mRNA species were found to differ among tissues and between a glioblastoma sample and a cell line derived from it. 7622042 1995
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.090 AlteredExpression disease BEFREE Using RT-PCR (reverse transcription-polymerase chain reaction) and primer extension assays, CTSB mRNA species were found to differ among tissues and between a glioblastoma sample and a cell line derived from it. 7622042 1995
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.090 AlteredExpression disease BEFREE Using RT-PCR (reverse transcription-polymerase chain reaction) and primer extension assays, CTSB mRNA species were found to differ among tissues and between a glioblastoma sample and a cell line derived from it. 7622042 1995
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases 		0.010 AlteredExpression group BEFREE The hypothesis that proteolytic enzymes release from cells adjacent to the site of destruction was recently supported by the presence of increased levels of cathepsin B, D, and L in the gingival crevicular fluid of patients suffering from periodontal disease (PD). 7637320 1995
CUI: C0021670
Disease: insulinoma
insulinoma 		0.010 Biomarker disease BEFREE Previous immunohistochemical studies have identified cathepsin B in secretory granules and lysosomes of human insulinoma cells. 7716141 1995
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.010 AlteredExpression disease BEFREE In contrast, levels of APPS and of tau did not correlate with dementia severity. 7717688 1995
CUI: C0497327
Disease: Dementia
Dementia 		0.010 AlteredExpression disease BEFREE In contrast, levels of APPS and of tau did not correlate with dementia severity. 7717688 1995
CUI: C0001126
Disease: Renal tubular acidosis
Renal tubular acidosis 		0.200 Biomarker phenotype RGD Renal tubular cell protein breakdown in uninephrectomized and ammonium chloride-loaded rats. 7873730 1994
CUI: C0017638
Disease: Glioma
Glioma 		0.300 AlteredExpression disease BEFREE Cathepsin B expression and localization in glioma progression and invasion. 7954439 1994
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE We have accumulated substantial evidence implicating the cysteine protease cathepsin B in human glioma malignancy. 7954439 1994
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 Biomarker phenotype BEFREE These data support the hypothesis that cathepsin B plays a role in human glioma progression and invasion. 7954439 1994
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE We have accumulated substantial evidence implicating the cysteine protease cathepsin B in human glioma malignancy. 7954439 1994