|
Asthma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine the association of ADRβ2 polymorphisms and haplotypes with asthma severity.
|
24691493 |
2014 |
|
Asthma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Increased β2-adrenoceptor phosphorylation in airway smooth muscle in severe asthma: possible role of mast cell-derived growth factors.
|
30069878 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine if these polymorphisms contribute to the development of asthma by investigating the associations between the polymorphisms at amino acid positions 16 and 27 of the B2AR gene and asthma-related parameters in a large, phenotypically well-characterized population which was unselected for asthma.
|
10469027 |
1999 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADRB2 Polymorphism and Salbutamol Responsiveness in Northern Indian Children with Mild to Moderate Exacerbation of Asthma.
|
27029682 |
2016 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Home dampness combined with each one of the genes STAT6, IL13 and ADRB2 could raise the asthma risk.
|
22355322 |
2012 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
β2-adrenoreceptor agonist (β2AA) are widely used for the treatment of asthma.
|
30114199 |
2018 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our hypothesis was that genotypic differences are associated with magnitude of response to ADRβ(2) agonist treatment during severe asthma exacerbations in children.
|
21905268 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent reports suggest that beta(2)-adrenergic receptor (ADRB2) genotypes are associated with therapeutic responses to beta(2) agonists in asthmatics.
|
18758858 |
2009 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study demonstrated that nocturnal asthma was associated with ADRB2 Arg/Gly polymorphisms but not with ADRB2 Gln/Glu polymorphisms.
|
23964556 |
2013 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma.
|
7739309 |
1995 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The authors analyze the possible implication of 7 genetic polymorphisms described as asthma susceptibility genes: IL13 (C-1112T and R130Q), IL4RA (I50V, Q551R), IL5 (C-746T) and ADRB2 (Q27E and R16G) in specific olive pollen allergic sensitization.
|
18849614 |
2009 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Association of haplotypes of beta2-adrenoceptor polymorphisms with lung function and airway responsiveness in a pediatric cohort.
|
17068824 |
2006 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults with asthma and to determine whether allelic variation at the Arg16Gly locus of the β2-adrenergic receptor (ADRB2) geneis associated with treatment response.
|
26505596 |
2015 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genetic variation in the β<sub>2</sub>-adrenergic receptor (ADRB2) gene has been thought to have an important role in the differential response to β<sub>2</sub>-agonist therapy for asthma.
|
28964817 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We used the haplotype FBAT program to test for associations between asthma phenotypes and single nucleotide polymorphisms (SNPs) in the beta-2 adrenergic receptor gene.
|
14691957 |
2004 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genes encoding for the high affinity IgE receptor, the beta 2-adrenergic receptor, and interleukin-4 have been linked to clinical characteristics of asthma.
|
9139767 |
1997 |
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Significantly higher levels of ADRB2 mRNA were observed in patients with severe asthma with persistent airflow limitation.
|
22192964 |
2012 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genotyping of GSNOR and beta2AR genes may be useful in identifying Latino individuals, who might benefit from adjuvant therapy for refractory asthma.
|
20335826 |
2010 |
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This study evaluates the utility of autopsy lung for studies of gene expression and examines the hypothesis that increased expression of beta 2 AR mRNA in peripheral lung underlies the increased receptor number reported in central airways in fatal asthma. beta 2AR mRNA levels have been quantitated using the ribonuclease protection assay on RNA from peripheral lung obtained both at autopsy and thoracotomy from subjects with normal lungs as well as subjects with asthma or chronic obstructive pulmonary disease (COPD).
|
7680566 |
1993 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We examined associations between the 4-gene model (IL13, IL4, FCER1B, and ADRB2) and the Asthma Predictive Index (API) and atopy in Chinese Han children.
|
29761786 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The β(2)AR-16 polymorphism confers a decreased risk toward asthma while the β(2)AR-27 polymorphism is not associated with asthma in the studied North Indian population.
|
22821646 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Importance of beta(2)adrenergic receptor genotype, gender and race on albuterol-evoked bronchodilation in asthmatics.
|
10873550 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No association was found between asthma and beta2AR genotypes.
|
12807170 |
2003 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Chronic stress has also been shown to result in biological changes such as expression of immunologic genes, changes in expression of the beta-adrenergic (B2AR) and the glucocorticoid receptor (GR-α) genes, cytokine regulation, and alterations in the hypothalamic pituitary axis and cortisol levels which all may affect asthma pathophysiology and therapeutic response among patients exposed to chronic stress.
|
31079340 |
2019 |