|
Asthma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This study evaluates the utility of autopsy lung for studies of gene expression and examines the hypothesis that increased expression of beta 2 AR mRNA in peripheral lung underlies the increased receptor number reported in central airways in fatal asthma. beta 2AR mRNA levels have been quantitated using the ribonuclease protection assay on RNA from peripheral lung obtained both at autopsy and thoracotomy from subjects with normal lungs as well as subjects with asthma or chronic obstructive pulmonary disease (COPD).
|
7680566 |
1993 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
It has long been hypothesized that a defective beta 2-adrenergic receptor (beta 2AR) may be a pathogenic factor in bronchial asthma.
|
8383511 |
1993 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma.
|
7739309 |
1995 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Beta 2 adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma.
|
7785006 |
1995 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.
|
7706471 |
1995 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Beta 2-adrenoreceptor agonists and glucocorticosteroids are the two most effective treatments for asthma and are often used in combination.
|
8834349 |
1996 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genes encoding for the high affinity IgE receptor, the beta 2-adrenergic receptor, and interleukin-4 have been linked to clinical characteristics of asthma.
|
9139767 |
1997 |
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We have found preliminary evidence that beta 2-adrenoceptor polymorphism is associated with altered beta 2-adrenoceptor expression in asthma patients.
|
9329515 |
1997 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The beta2-adrenergic receptor (beta2AR) agonists are the most widely used agents in the treatment of asthma, but the genetic determinants of responsiveness to these agents are unknown.
|
9399966 |
1997 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus beta2AR polymorphisms act as disease modifiers in asthma and represent one of probably many genetic variables involved in the pathophysiology of asthma.
|
9351598 |
1997 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This observation suggests therefore that ADRB2 gene can confer genetic susceptibility to BHR, rather than having only a disease-modifying effect in asthma.
|
9847294 |
1998 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, allele frequency variation among ethnic groups must be considered in clinical studies of beta2AR polymorphisms in asthma.
|
9731005 |
1998 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine if these polymorphisms contribute to the development of asthma by investigating the associations between the polymorphisms at amino acid positions 16 and 27 of the B2AR gene and asthma-related parameters in a large, phenotypically well-characterized population which was unselected for asthma.
|
10469027 |
1999 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that beta2AR polymorphisms play an important role in the airway responsiveness to inhaled beta2-agonist and the initial asthma onset.
|
10524541 |
1999 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Importance of beta(2)adrenergic receptor genotype, gender and race on albuterol-evoked bronchodilation in asthmatics.
|
10873550 |
2000 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This notion is supported by several reports that have implicated the chromosomal region 5q31-q33 harboring the gene for the beta(2)-adrenoreceptor in the genetics of asthma and related phenotypes.
|
10673187 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that the observed linkage to asthma in the 5q23-31 region is unrelated to variation in the beta(2)AR gene.
|
10934093 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To date, clinical studies suggest that these beta(2)AR polymorphisms may alter asthmatic phenotype and the response to beta-agonist therapy, making these variants the first of undoubtedly several genetic loci that will ultimately be found that will provide for individualized therapy in asthma.
|
10669529 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the polymorphisms of amino acids 16 and 27 of the beta2AR gene are not associated with the development of asthma per se, but that the Gly16 polymorphism may play a role in the pathogenesis of asthma severity.
|
10931116 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the United Kingdom, about 40% of patients with asthma are homozygous for the glycine-16 beta(2)-adrenoceptor polymorphism, which predisposes them to agonist-induced down-regulation and desensitization of the beta(2)-adrenoceptor.
|
10967152 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined whether polymorphisms at codon 16 (beta(2)-AR-16) and codon 27 (beta(2)-AR-27) of the beta(2)-AR might affect the response to regular versus as-needed use of albuterol by genotyping the 190 asthmatics who had participated in a trial examining the effects of regular versus as needed albuterol use.
|
10903223 |
2000 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In a retrospective analysis of previously published data we have examined relationships between polymorphisms at codons 16 and 27 of the beta(2) adrenoceptor and clinical outcomes in a randomised, placebo controlled, crossover trial of regularly scheduled salbutamol and salmeterol in 115 patients with mild to moderate asthma.
|
10950895 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We performed a retrospective analysis of our database (n = 487) of patients with asthma with the aim first, to compare methacholine and AMP challenge as screening tools, and second, to identify any relationships between BHR and disease severity markers or beta(2)-adrenoceptor genotype.
|
11029338 |
2000 |