|
Asthma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Asthma models show increased ASM G(alphai) expression, considered the basis for the proasthmatic phenotypes of enhanced bronchial hyperreactivity to contraction mediated by M(3)-muscarinic receptors and diminished relaxation mediated by beta(2)-adrenergic receptors (beta(2)ARs).
|
17415415 |
2007 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Bronchial asthma (BA) is a chronic inflammatory disorder of airways for which the effective therapies include inhaled corticosteroids (ICS) and short-acting β2-adrenoreceptor agonist (SABA).
|
28781336 |
2017 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
beta(2)-Adrenergic receptor polymorphisms and asthma.
|
11224726 |
2001 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Beta-2 adrenergic receptor (B2AR) agonists are the most widely prescribed rescue agents used in the treatment of asthma.
|
11412813 |
2001 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADRB2 haplotype was determined in 176 patients with asthma, of whom 161 harbored the six most common combinations.
|
15976384 |
2005 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
ADRB2 genotyping of patients with severe or difficult-to-control asthma may shed light on a possible contributor to their clinical instability.
|
18035963 |
2007 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Beta(2)-adrenergic receptor haplotype/polymorphisms and asthma susceptibility and clinical phenotype in a Chinese Han population.
|
20929600 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADRB2 Arg16Gly showed a significant interactive effect with home dampness on being awakened at night due to wheezing and current wheezing, but no significant effect on active asthma and medication use.
|
22883364 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADRB2-c.16*AG is a risk factor (3.5-fold), while genotype GSDML-236*TT was protective (4-fold) for moderate-severe asthma.
|
25299150 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADRB2 Polymorphism and Salbutamol Responsiveness in Northern Indian Children with Mild to Moderate Exacerbation of Asthma.
|
27029682 |
2016 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
β2-adrenoreceptor agonist (β2AA) are widely used for the treatment of asthma.
|
30114199 |
2018 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
β2-Adrenergic receptor (β2AR) agonists are clinically used to elicit rapid bronchodilation for the treatment of bronchospasms in pulmonary diseases such as asthma and COPD, both of which exhibit characteristically high levels of reactive oxygen species (ROS); likely secondary to over-expression of ROS generating enzymes and chronically heightened inflammation.
|
31697929 |
2020 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Beta 2 adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma.
|
7785006 |
1995 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Beta 2-adrenoreceptor agonists and glucocorticosteroids are the two most effective treatments for asthma and are often used in combination.
|
8834349 |
1996 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A cross-sectional survey was undertaken using electronic records, direct interviews, and genotype determination of position 16 and 27 of the ADRB2 gene in DNA from mouthwash samples of 546 children and young asthmatics attending paediatric and young adult asthma clinics in Tayside, Scotland during 2004-5.
|
16772309 |
2006 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A subset of asthmatics shows refractoriness to Salbutamol owing to ADRB2 gene C.T polymorphism (rs 1800888) that substitutes Thr to Ile at the position 164 in the β2 adrenergic receptor leading to sub-optimal binding of Salbutamol.
|
27174812 |
2016 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After subgroup analysis by age, the ACE D/I, β2-Adrenergic Receptor (β2-AR) -79G/C, TNF-α -308G/A, Interleukin 4 receptor(IL-4R) -1902G/A and IL-13 -1923C/T polymorphisms were found significantly associated with asthma risk in Chinese children.
|
20868478 |
2010 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Allele, genotype, and haplotype frequencies of the ADRB2 gene between asthmatic and non-asthmatic as well as demographic, clinical, and spirometric variables among asthmatic patients according to their genotype were compared.
|
22328447 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Allelic variants at codons 16 and 27 of the beta(2)-adrenergic receptor gene (ADRB2) have shown clinical and pharmacological implications in asthma, hypertension, ischemic heart failure, diabetes, obesity, and cystic fibrosis.
|
18440968 |
2008 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although relationships between bronchial asthma and the function of clock genes remain unclear, some medications given for asthma such as glucocorticoids or beta(2)-adrenoceptor agonists may influence clock genes in vivo.
|
17299247 |
2007 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort.
|
24279851 |
2013 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
As increased inflammatory mediator expression is prevented by the addition of glucocorticoid to the beta(2)-adrenoceptor, our data provide further mechanistic support for the use of combination therapies in asthma management.
|
20423350 |
2010 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Association of haplotypes of beta2-adrenoceptor polymorphisms with lung function and airway responsiveness in a pediatric cohort.
|
17068824 |
2006 |