|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine the association of ADRβ2 polymorphisms and haplotypes with asthma severity.
|
24691493 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine if these polymorphisms contribute to the development of asthma by investigating the associations between the polymorphisms at amino acid positions 16 and 27 of the B2AR gene and asthma-related parameters in a large, phenotypically well-characterized population which was unselected for asthma.
|
10469027 |
1999 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADRB2 Polymorphism and Salbutamol Responsiveness in Northern Indian Children with Mild to Moderate Exacerbation of Asthma.
|
27029682 |
2016 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent reports suggest that beta(2)-adrenergic receptor (ADRB2) genotypes are associated with therapeutic responses to beta(2) agonists in asthmatics.
|
18758858 |
2009 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study demonstrated that nocturnal asthma was associated with ADRB2 Arg/Gly polymorphisms but not with ADRB2 Gln/Glu polymorphisms.
|
23964556 |
2013 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma.
|
7739309 |
1995 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The authors analyze the possible implication of 7 genetic polymorphisms described as asthma susceptibility genes: IL13 (C-1112T and R130Q), IL4RA (I50V, Q551R), IL5 (C-746T) and ADRB2 (Q27E and R16G) in specific olive pollen allergic sensitization.
|
18849614 |
2009 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Association of haplotypes of beta2-adrenoceptor polymorphisms with lung function and airway responsiveness in a pediatric cohort.
|
17068824 |
2006 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults with asthma and to determine whether allelic variation at the Arg16Gly locus of the β2-adrenergic receptor (ADRB2) geneis associated with treatment response.
|
26505596 |
2015 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We used the haplotype FBAT program to test for associations between asthma phenotypes and single nucleotide polymorphisms (SNPs) in the beta-2 adrenergic receptor gene.
|
14691957 |
2004 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The β(2)AR-16 polymorphism confers a decreased risk toward asthma while the β(2)AR-27 polymorphism is not associated with asthma in the studied North Indian population.
|
22821646 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Importance of beta(2)adrenergic receptor genotype, gender and race on albuterol-evoked bronchodilation in asthmatics.
|
10873550 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No association was found between asthma and beta2AR genotypes.
|
12807170 |
2003 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Chronic stress has also been shown to result in biological changes such as expression of immunologic genes, changes in expression of the beta-adrenergic (B2AR) and the glucocorticoid receptor (GR-α) genes, cytokine regulation, and alterations in the hypothalamic pituitary axis and cortisol levels which all may affect asthma pathophysiology and therapeutic response among patients exposed to chronic stress.
|
31079340 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The aim of this study was to examine the associations between the beta ( 2 ) AR polymorphisms and risks of asthma, chronic obstructive pulmonary disease (COPD) and respiratory symptoms in a sample of adults.
|
16946993 |
2006 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our research suggested that in asthmatic patients of Chinese Han nationality, the beta(2)-AR genetic polymorphism at 27 loci could be associated with serum IgE levels and it might therefore play an important role in the determination of phenotypes of bronchial asthma.
|
16369119 |
2006 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast, although not associated with the diagnosis of asthma per se, variant forms of the beta(2)-adrenoceptor (beta2-AR) gene (ADRB2) display functional effects that may be clinically relevant.
|
12083965 |
2001 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The Gly16 polymorphism of beta(2)-AR was overrepresented in nocturnal asthmatic patients, correlated with nocturnal asthma, and therefore appeared to be an important genetic factor in the expression of this asthmatic phenotype.
|
16369120 |
2006 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The role of polymorphisms of the β2-adrenergic receptor and their relationship with nocturnal asthma remain controversial.
|
22045347 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The MS4A2 C-109T T/T and ADRB2 R16G A/A genotypes were associated with asthma in the Chinese Han children.
|
24838642 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Eleven single nucleotide polymorphisms (SNPs) in CHRM1-3 (coding muscarinic receptors one to three) which were identified by re-sequencing, and Arg16Gly and Gln27Glu in ADRB2 (coding beta(2) adrenoreceptor) were scored in 80 of the 138 asthmatics.
|
19183167 |
2009 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
JAK-3 mediates cytokine signaling, while DNA methylation in the ADRB2 gene decreases asthma symptom severity.
|
29956621 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We determined frequencies of these polymorphisms to explore the association between beta(2)AR haplotypes and asthma diagnosis and phenotype.
|
14657864 |
2003 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
beta(2)-Adrenergic receptor polymorphisms and asthma.
|
11224726 |
2001 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
So, GRK5-Leu41 represents a gain-of-function polymorphism that evokes enhanced loss-of-function of beta2AR during persistent agonist exposure, and thus may contribute to beta-agonist variability in asthma treatment of African-Americans.
|
18622265 |
2008 |