Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
T cell recognition of Dsg3 was thus not only restricted by the pemphigus vulgaris associated DRbeta1*0402 allele, but also by several DR11 alleles, some of which are highly homologous to DRbeta1*0402, and by HLA-DQbeta1*0301.
|
9540980 |
1998 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
We demonstrate that Pkp3 becomes tyrosine phosphorylated as early as 30 min upon binding of PV IgG to keratinocyte surface and eventually detaches from its binding partner desmoglein 3 (Dsg3).
|
24328683 |
2014 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Sera from patients with PV contained significantly greater levels of anti-Dsg3 autoantibodies than walnut-specific antibodies, suggesting that the autoreactive B-cell response in patients with PV might be initially triggered by walnut antigens but is subsequently driven by Dsg3.
|
31071340 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Dsg3- but not Dsg2-deficient cells were protected against PV-IgG-induced loss of cell adhesion.
|
31178865 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
We provide evidence that both pemphigus foliaceus-IgG containing Dsg 1- but not Dsg 3-specific antibodies and pemphigus vulgaris-IgG with antibodies to Dsg 1 and Dsg 3 were equally effective in causing epidermal splitting in human skin and keratinocyte dissociation in vitro.
|
17640963 |
2007 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus.
|
31077459 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, the genes for two autoantigens (DSG1 for pemphigus foliaceus and DSG3 for pemphigus vulgaris) were mapped on band q12 of human chromosome 18 by fluorescence in situ hybridization.
|
8034325 |
1994 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
These observations allow us to propose a concept for pemphigus blistering disorders as a "desmosome-remodeling impairment disease" involving a mechanism of Dsg3 nonassembly and depletion from desmosomes through PV immunoglobulin G-activated intracellular signaling events.
|
23257250 |
2013 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
The cDNA sequence and the baculovirus recombinant protein of canine Dsg3 will be useful to characterize the serum autoantibodies in canine PV.
|
14507443 |
2003 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
All PV-IgG fractions and AK23 compromised Dsg3 but not Dsg1 binding and enhanced Src activity.
|
28620161 |
2017 |
Pemphigus Vulgaris
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, we found a middle-aged woman with severe disease with circulating anti-Dsg3 antibodies at high levels, typical of pemphigus vulgaris.
|
26567062 |
2016 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is an autoimmune blistering disease, in which autoantibodies against PV antigen (PVA or Dsg3) play a pathogenic role in inducing blister formation.
|
8040292 |
1994 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
It was assumed that PV is caused by anti-desmoglein (Dsg) 3 autoimmunity because absorption of PV sera with a chimeric baculoprotein containing the Dsg 3 and IgG1 portions, rDsg3-Ig-His, eliminated disease-causing antibodies.
|
11021840 |
2000 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Thus, monitoring of Dsg3-specific B cells in PV is of particular interest to further characterize the immunopathogenesis of PV.
|
31258541 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
These observations strongly suggest 1) that the appearance of Dsg3-reactive Th2 cells is restricted to patients with PV; 2) that specific HLA class II alleles that are prevalent in PV are critical for T cell recognition of Dsg3 in PV patients and Dsg3-responsive healthy donors; and 3) that autoAb production is associated with both Th1 and Th2 cells.
|
12496453 |
2003 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
The PV antigen (PVA) has been characterized as desmoglein 3.
|
7761479 |
1995 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
The mucosal blister-producing PV variant is characterized by autoantibodies against desmoglein (Dsg)3, whereas mucosal and skin lesion-producing PV is characterized by autoantibodies to Dsg3 and Dsg1.
|
17442983 |
2007 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris.
|
31774569 |
2020 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
The BIOCHIP was found to have a sensitivity of 60.9% and specificity of 73.6% for Dsg3 in PV.
|
31260565 |
2020 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
To define cut-off values for Dsg1, Dsg3, and BP180, we evaluated 47 serum samples from patients with pemphigus foliaceus (PF), 59 from those with pemphigus vulgaris (PV), 52 from those with bullous pemphigoid (BP), and 995 from healthy individuals.
|
28012821 |
2017 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Specific Human Leukocyte Antigen Class II (HLA II) molecules associated with pemphigus vulgaris (PV), mucous membraine pemphigoid (MMP), and mixed connective tissue disease (MCTD) may react with multiple T cell epitopes within desmoglein 3 (Dsg 3), bullous pemphigoid antigen 2 (BPAG 2), and 70 kDa polypeptide small nuclear ribonucleoproteins (snRNP70) in autoantibody production.
|
22053914 |
2012 |
Pemphigus Vulgaris
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Among the large number of studied SNPs, it was found that several SNPs in different genes might control the susceptibility of PV, including TNFA (rs361525, rs1800629, rs1800629), IL10 (rs1800871, rs1800896, rs1800871, and rs1800872), IL6 (rs1800795), CTLA4 (rs231775), ICOS (rs10932029), CD86 (rs1129055), DSG3 (rs8085532, rs3911655, rs3848485, rs3794925, rs1466379), ST18 (rs2304365, rs17315309) and TAP2 (rs7454108), probably in a population-specific manner.
|
31342641 |
2020 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, the inhibitory antibody against Ecad but not a Dsg3-specific PV antibody interfered with stimulated lipid production.
|
31121132 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
On the other hand, fundamental doubt has been raised towards this monopathogenic view by several independent factors: (1) pemphigus lesions can be induced in Dsg3-knockout (KO) mice; (2) pemphigus sera contain multiple autoantibodies against different adhesion molecules and also cholinergic receptors; (3) experimental inhibition of PV IgG induced acantholysis can be obtained by interference with different signaling cascades regulating both calcium homeostasis and apoptosis; and (4) cholinergic agonists exhibit anti-acantholytic activity both in vitro and in vivo.
|
17101498 |
2006 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Desmoglein 3, the target antigen of pemphigus vulgaris, an IgG-mediated autoimmune blistering disease, was used in a HaloTag protein barcode assay to detect the anti-DSG3 antibody.
|
31752022 |
2020 |