DSG3, desmoglein 3, 1830

N. diseases: 78; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE The relative decrease of Dsg3 (PVA) during epidermal differentiation might be responsible for the induction of suprabasal acantholysis in PV. 7547386 1995
CUI: C0263313
Disease: Pemphigus Foliaceus
Pemphigus Foliaceus 		0.100 Biomarker disease BEFREE Epidermal desmogleins with molecular weights of 130/140 kDa (Dsg3 or PVA) and 150/160 kDa (Dsg1 or DGI) are recognized by autoantibodies from patients with pemphigus vulgaris (PV) and pemphigus foliaceus (PF), respectively. 7547386 1995
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE The PV antigen (PVA) has been characterized as desmoglein 3. 7761479 1995
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE In this study, the genes for two autoantigens (DSG1 for pemphigus foliaceus and DSG3 for pemphigus vulgaris) were mapped on band q12 of human chromosome 18 by fluorescence in situ hybridization. 8034325 1994
CUI: C0263313
Disease: Pemphigus Foliaceus
Pemphigus Foliaceus 		0.100 Biomarker disease BEFREE In this study, the genes for two autoantigens (DSG1 for pemphigus foliaceus and DSG3 for pemphigus vulgaris) were mapped on band q12 of human chromosome 18 by fluorescence in situ hybridization. 8034325 1994
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is an autoimmune blistering disease, in which autoantibodies against PV antigen (PVA or Dsg3) play a pathogenic role in inducing blister formation. 8040292 1994
CUI: C0030807
Disease: Pemphigus
Pemphigus 		0.100 Biomarker disease BEFREE These results indicate that this baculovirus product has the proper conformation of the authentic PVA and that its conformation is important in pathogenicity of pemphigus. 8040292 1994
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Analysis by immunofluorescence and flow cytometry with pemphigus vulgaris sera indicated that the pemphigus vulgaris antigen extracellular domain of this chimeric molecule (PVEC) was expressed on the cell surface of transiently transfected cells and permanently transfected L-cell clones. 8043076 1994
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease MGD Balding: a new mutation on mouse chromosome 18 causing hair loss and immunological defects. 8182278 1994
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE PVA and an extracellular domain of PVA-Ig fusion protein (PV-Ig) can completely adsorb the blister-causing Abs from PV patient sera, suggesting that the extracellular segment of PVA might be sufficient to induce pathogenic Abs. 8816430 1996
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is a blistering disease of the skin and mucous membranes characterized by an autoantibody response against a keratinocyte adhesion molecule, desmoglein 3, causing acantholysis and blister formation. 9008309 1996
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease MGD Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. 9166409 1997
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.050 Biomarker group BEFREE Thus, desmoglein 3 is identified as a target antigen in intraepidermal neutrophilic IgA dermatosis. 9176383 1997
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE These Ag-specific ELISAs revealed that more than one-half of PV sera (26 of 49) had anti-Dsg1 Abs in addition to anti-Dsg3 Abs. 9257868 1997
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease MGD Vesicle formation and follicular root sheath separation in mice homozygous for deleterious alleles at the balding (bal) locus. 9284099 1997
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE T cell recognition of Dsg3 was thus not only restricted by the pemphigus vulgaris associated DRbeta1*0402 allele, but also by several DR11 alleles, some of which are highly homologous to DRbeta1*0402, and by HLA-DQbeta1*0301. 9540980 1998
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.090 Biomarker group BEFREE Pemphigus vulgaris is a life threatening bullous autoimmune disease of the skin mediated by autoantibodies against desmoglein 3 (Dsg3) on epidermal keratinocytes. 9540980 1998
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) not only developed mucous membrane and skin lesions like pemphigus patients, but also developed hair loss. 9701552 1998
CUI: C0030807
Disease: Pemphigus
Pemphigus 		0.100 Biomarker disease BEFREE Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) not only developed mucous membrane and skin lesions like pemphigus patients, but also developed hair loss. 9701552 1998
CUI: C0037284
Disease: Skin lesion
Skin lesion 		0.020 Biomarker group BEFREE Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) not only developed mucous membrane and skin lesions like pemphigus patients, but also developed hair loss. 9701552 1998
CUI: C0002170
Disease: Alopecia
Alopecia 		0.010 Biomarker disease BEFREE Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) not only developed mucous membrane and skin lesions like pemphigus patients, but also developed hair loss. 9701552 1998
CUI: C0151785
Disease: Disease of mucous membrane
Disease of mucous membrane 		0.010 Biomarker group BEFREE Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) not only developed mucous membrane and skin lesions like pemphigus patients, but also developed hair loss. 9701552 1998
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is an autoimmune disease mediated by autoantibodies that bind to a keratinocyte adhesion molecule, desmoglein-3. 9714477 1998
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are caused by autoantibodies against keratinocyte adhesion molecules desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), respectively. 10551416 1999
CUI: C0263313
Disease: Pemphigus Foliaceus
Pemphigus Foliaceus 		0.100 Biomarker disease BEFREE Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are caused by autoantibodies against keratinocyte adhesion molecules desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), respectively. 10551416 1999