DSG3, desmoglein 3, 1830

N. diseases: 78; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are caused by autoantibodies against keratinocyte adhesion molecules desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), respectively. 10551416 1999
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) and pemphigus foliaceus (PF), in which autoantibodies bind, respectively, to desmoglein 3 and desmoglein 1, are strongly associated with HLA-class II DR4 and DR14 alleles. 12604316 2003
CUI: C0030807
Disease: Pemphigus
Pemphigus 		0.100 Biomarker disease BEFREE Pemphigus is a life-threatening blistering disorder of the skin and mucous membranes caused by pathogenic autoantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1. 15841178 2005
CUI: C0263313
Disease: Pemphigus Foliaceus
Pemphigus Foliaceus 		0.100 Biomarker disease BEFREE Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are autoimmune blistering diseases characterized by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively. 18219275 2008
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is an acquired autoimmune blistering disorder in which greater than 80% of active patients produce autoantibodies to the desmosomal protein desmogelin 3 (Dsg3). 18564435 2008
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3. 28321152 2017
CUI: C0030807
Disease: Pemphigus
Pemphigus 		0.100 Biomarker disease BEFREE Pemphigus is an autoimmune blistering disease targeting the desmosomal proteins desmoglein (Dsg) 1 and Dsg3. 31057535 2019
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus. 31077459 2019
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering sores on skin and mucosal membranes, caused by autoantibodies primarily targeting the cellular adhesion protein, desmoglein-3 (Dsg3). 31340153 2019
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is an autoimmune blistering disease, in which autoantibodies against PV antigen (PVA or Dsg3) play a pathogenic role in inducing blister formation. 8040292 1994
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is a blistering disease of the skin and mucous membranes characterized by an autoantibody response against a keratinocyte adhesion molecule, desmoglein 3, causing acantholysis and blister formation. 9008309 1996
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is an autoimmune disease mediated by autoantibodies that bind to a keratinocyte adhesion molecule, desmoglein-3. 9714477 1998
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 AlteredExpression disease BEFREE Desmoglein-3 (dsg-3) expressed in the suprabasal layer of the skin serves as an autoantigen in PV. 12653831 2003
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Dsg3-specific T-cell responses were detected in PV patients but also in healthy individuals who were either carriers of the PV-associated DRB1*0402 allele or alleles that share similar or identical peptide binding motifs to DRB1*0402. 12878355 2003
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.050 Biomarker group BEFREE PVA and SFTPB are particularly powerful in tumors of squamous and adenocarcinoma histologies, respectively, whereas TACSTD1 is a good general marker for NSCLC metastasis. 16638856 2006
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.030 Biomarker disease BEFREE PVA and SFTPB are particularly powerful in tumors of squamous and adenocarcinoma histologies, respectively, whereas TACSTD1 is a good general marker for NSCLC metastasis. 16638856 2006
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Desmoglein 3 is targeted in pemphigus vulgaris while desmoglein 1 is targeted in pemphigus foliaceus and its endemic form, Fogo Selvagem. 18838249 2008
CUI: C0263313
Disease: Pemphigus Foliaceus
Pemphigus Foliaceus 		0.100 Biomarker disease BEFREE Desmoglein 3 is targeted in pemphigus vulgaris while desmoglein 1 is targeted in pemphigus foliaceus and its endemic form, Fogo Selvagem. 18838249 2008
CUI: C0263314
Disease: Pemphigus and fogo selvagem
Pemphigus and fogo selvagem 		0.020 Biomarker disease BEFREE Desmoglein 3 is targeted in pemphigus vulgaris while desmoglein 1 is targeted in pemphigus foliaceus and its endemic form, Fogo Selvagem. 18838249 2008
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.080 AlteredExpression group BEFREE PVA levels had a trend toward association with clinical outcome, specifically time to death caused by cancer, but this was confounded by tumor stage. 23625795 2013
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.080 AlteredExpression group BEFREE PVA levels had a trend toward association with clinical outcome, specifically time to death caused by cancer, but this was confounded by tumor stage. 23625795 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 Biomarker phenotype BEFREE Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation. 23752190 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.060 Biomarker disease BEFREE Desmoglein 3 (Dsg3), the pemphigus vulgaris antigen, has recently been shown to be upregulated in squamous cell carcinoma (SCC) and has been identified as a good tumor-specific marker for clinical staging of cervical sentinel lymph nodes in head and neck SCC. 23752190 2014
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris 		0.300 Biomarker disease BEFREE Dsg3-reactive T regulatory cells (Treg) have been previously identified in PV and healthy carriers of PV-associated HLA class II alleles. 26661498 2016
CUI: C0151546
Disease: Oral Cavity Carcinoma
Oral Cavity Carcinoma 		0.010 Biomarker disease BEFREE Desmoglein 3 - Influence on oral carcinoma cell migration and invasion. 29969588 2018