ELK4, ETS transcription factor ELK4, 2005

N. diseases: 32; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.010 AlteredExpression disease BEFREE Furthermore, in vivo, ELK4 downregulation reduced tumor formation in glioblastoma xenograft models. 21846680 2011
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE The critical role of ELK4 in Mcl-1 expression and protection from apoptosis in glioma defines ELK4 as a novel potential therapeutic target for GBM. 21846680 2011
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 Biomarker disease BEFREE The amplified HBV DNA fragments were inserted into pHY106 vectors by Sap I digestion. 18567076 2008
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.010 Biomarker group BEFREE Isolates of Candida albicans from the oral cavities of subjects at different stages of human immunodeficiency virus (HIV) infection or uninfected controls were examined for (i) production of aspartic proteinase(s), a putative virulence-associated factor(s); (ii) the presence in the fungal genome of two major genes (SAP1 and SAP2) of the aspartic proteinase family; and (iii) experimental pathogenicity in a murine model of systemic infection. 8550193 1996
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.010 Biomarker group BEFREE Here we show that SAP-1 ablation in interleukin (IL)-10-deficient mice, a model of inflammatory bowel disease, resulted in a marked increase in the severity of colitis in association with up-regulation of mRNAs for various cytokines and chemokines in the colon. 26195794 2015
CUI: C0023522
Disease: Leukodystrophy, Metachromatic
Leukodystrophy, Metachromatic 		0.010 Biomarker disease BEFREE The mechanism for a 33-nucleotide insertion in mRNA causing sphingolipid activator protein (SAP-1)-deficient metachromatic leukodystrophy. 2066109 1991
CUI: C0023524
Disease: Leukoencephalopathy, Progressive Multifocal
Leukoencephalopathy, Progressive Multifocal 		0.010 Biomarker disease BEFREE It could be shown that the basic structures of the regulatory regions are similar between Sap-1 and isolates from cerebral PML. 1313631 1992
CUI: C0024530
Disease: Malaria
Malaria 		0.010 GeneticVariation disease BEFREE Targeted deletion of SAP1 in the rodent malaria parasite Plasmodium yoelii generated mutant parasites that traverse and invade hepatocytes normally but cannot initiate liver-stage development in vitro and in vivo. 18466298 2008
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 Biomarker disease BEFREE Among 72 polymerase chain reaction clones, one of the cDNA sequences encoded a novel potential PTP (stomach cancer-associated PTP, SAP-1). 8294459 1994
CUI: C0025202
Disease: melanoma
melanoma 		0.010 AlteredExpression disease BEFREE In addition, ELK4 is overexpressed in melanoma and knocking down the ELK4 or CDK2 expression significantly attenuated the malignant phenotype of melanoma cells. 26028036 2016
CUI: C0243026
Disease: Sepsis
Sepsis 		0.010 Biomarker disease BEFREE Isolates of Candida albicans from the oral cavities of subjects at different stages of human immunodeficiency virus (HIV) infection or uninfected controls were examined for (i) production of aspartic proteinase(s), a putative virulence-associated factor(s); (ii) the presence in the fungal genome of two major genes (SAP1 and SAP2) of the aspartic proteinase family; and (iii) experimental pathogenicity in a murine model of systemic infection. 8550193 1996
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.010 AlteredExpression disease BEFREE Furthermore, in vivo, ELK4 downregulation reduced tumor formation in glioblastoma xenograft models. 21846680 2011
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.010 AlteredExpression disease BEFREE Furthermore, in vivo, ELK4 downregulation reduced tumor formation in glioblastoma xenograft models. 21846680 2011
CUI: C0404521
Disease: Infective vaginitis
Infective vaginitis 		0.010 Biomarker disease BEFREE These data provide further evidence for a crucial role of Sap1 and Sap2 in C. albicans vaginal infections. 12761103 2003
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 AlteredExpression disease BEFREE We here show for the first time that the most common genomic copy number gains in breast cancer, 1q21 and 1q32, are associated with overexpression of the ETS transcription factors ETV3 and ELF3 (but not ELK4) at these loci irrespective of molecular subtypes. 23329352 2013
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.010 GeneticVariation disease BEFREE ETV-1, ETV-4, ETV-5, and ELK-4 rearrangements were found in 8 (10%) of 81, 5 (6%) of 85, 1 (1%) of 85, and 2 (2%) of 86 of primary prostate cancer, respectively, and in 6 (8%) of 73, 4 (6%) of 72, 1 (1%) of 75, and 1 (1%) of 78 of corresponding lymph node metastases, respectively. 22569213 2012
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 Biomarker disease BEFREE Among 72 polymerase chain reaction clones, one of the cDNA sequences encoded a novel potential PTP (stomach cancer-associated PTP, SAP-1). 8294459 1994
CUI: C0700345
Disease: Candidiasis, Vulvovaginal
Candidiasis, Vulvovaginal 		0.010 Biomarker disease BEFREE SAP 1 and SAP 3 transcripts were observed only in patients with VVC and RVVC. 17714358 2007
CUI: C1112211
Disease: Hepatic Infection
Hepatic Infection 		0.010 Biomarker disease BEFREE These findings demonstrate that SAP1 is essential for liver infection possibly by functioning as a selective regulator controlling the expression of infectivity-associated parasite effector genes. 18466298 2008
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.010 Biomarker disease BEFREE The critical role of ELK4 in Mcl-1 expression and protection from apoptosis in glioma defines ELK4 as a novel potential therapeutic target for GBM. 21846680 2011
CUI: C3714731
Disease: Early childhood caries
Early childhood caries 		0.010 AlteredExpression disease BEFREE Moreover, secreted aspartic protease (Sap) activity and SAP1-5 transcriptional levels were compared in the ECC and caries-free (CF) groups of Uygur children. 30518349 2018
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.020 AlteredExpression group LHGDN Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. 18469865 2008