|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We propose that through convergence on AKT/mTOR signaling, these genes are critical factors directing both placentation and neurodevelopment, influencing risk for SCZ through dysregulation of placental function, metabolism and early brain development.
|
31522868 |
2019 |
|
Schizophrenia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this review is to detail how putative schizophrenia risk genes (DISC-1, neuregulin/ErbB4, dysbindin, Akt1, BDNF, and the NMDA receptor) are involved in regulating neuroplasticity and how alterations in their expression may contribute to the disconnectivity observed in schizophrenia.
|
20951727 |
2011 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our findings did not confirm the association of AKT1 SNP2/3/4 TCG haplotype with the risk of schizophrenia as reported in the original study but showed the evidence of association with a different haplotype, AKT1 five-SNP AGCAG haplotype, with the risk of schizophrenia in Iranian population.
|
16583435 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
MGD |
Consistent with this proposal, we also show that haloperidol induces a stepwise increase in regulatory phosphorylation of AKT1 in the brains of treated mice that could compensate for an impaired function of this signaling pathway in schizophrenia.
|
14745448 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity.
|
15581715 |
2005 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This analysis identified 624 genes with altered expression (208 up-regulated, 416 down-regulated) prior to antipsychotic treatment (p < 0.05) including schizophrenia-associated genes AKT1, DISC1 and DGCR6.
|
23442539 |
2013 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the association of genetic variation in AKT1 with neurocognition was investigated in patients with schizophrenia.
|
17464696 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects.
|
16987250 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia.
|
21187413 |
2011 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Thus, our study does not indicate that AKT1 or DTNBP1 play a role in the etiology of schizophrenia in the Finnish population.
|
17300918 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia.
|
15522255 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Many susceptible genes have been identified in schizophrenia such as catechol-O-methyltransferase (COMT) and serine/threonine kinase (AKT1).
|
25801838 |
2015 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia.
|
21187413 |
2011 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Supportive of an earlier tentative association of AKT1 with schizophrenia, we also found that this AKT1 variant was associated with risk for schizophrenia.
|
18497887 |
2008 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Taken together, our results do not support the hypothesis that AKT1 is a susceptibility gene for schizophrenia.
|
19931325 |
2010 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
|
23246288 |
2013 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Taken together, these results implicate the Akt1 isoform in regulating hippocampal neuroplasticity and cognition and in contributing to the etiology of schizophrenia.
|
21049487 |
2012 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In this study, our aim was to determine whether AKT1 gene variants are associated with particular phenotypes for schizophrenia (SCZ) and bipolar disorder (BPD).
|
22277669 |
2012 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Patients were genotyped for eight AKT1 Single Nucleotide Polymorphism (SNPs), which have been previously investigated for association with schizophrenia.
|
18635704 |
2009 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Exploratory haplotype analysis confirmed association with schizophrenia toward the 5' end of AKT1 (.008 < p < .049, uncorrected).
|
17825267 |
2008 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Recent investigations suggest that the AKT/glycogen synthase kinase 3 (GSK3) signaling cascade may be associated with the pathophysiology of schizophrenia and methamphetamine (METH) use disorder.
|
17233643 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
This association is likely to reflect modulation of dopamine signaling by Akt1 kinase since striatal dopamine hyperstimulation is associated with psychosis and schizophrenia.
|
28416594 |
2017 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We examined eight polymorphisms spanning the AKT1 gene and their association with TD in our schizophrenia sample of 193 Caucasians, 76 of which with TD.
|
18838251 |
2008 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings, by showing the involvement of the AKT1 gene in both schizophrenia and bipolar disorder, support the role of AKT1 in the genetics of both disorders and add support to the view that there is some genetic overlap between them.
|
20214684 |
2010 |