|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
MGD |
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.
|
11533044 |
2001 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
MGD |
Consistent with this proposal, we also show that haloperidol induces a stepwise increase in regulatory phosphorylation of AKT1 in the brains of treated mice that could compensate for an impaired function of this signaling pathway in schizophrenia.
|
14745448 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Consistent with this proposal, we also show that haloperidol induces a stepwise increase in regulatory phosphorylation of AKT1 in the brains of treated mice that could compensate for an impaired function of this signaling pathway in schizophrenia.
|
14745448 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
Consistent with this proposal, we also show that haloperidol induces a stepwise increase in regulatory phosphorylation of AKT1 in the brains of treated mice that could compensate for an impaired function of this signaling pathway in schizophrenia.
|
14745448 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
While our previous data on GSK-3beta in postmortem brain and the recent report that there is impaired AKT1-GSK-3beta signaling in schizophrenia suggest that changes in pathways involving protein kinases such as AKT1 and GSK-3beta in schizophrenia are complex, our present data do not provide strong evidence in support of the involvement of GSK-3beta in schizophrenia.
|
15474909 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia.
|
15522255 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
LHGDN |
Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia.
|
15522255 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity.
|
15581715 |
2005 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples.
|
15982448 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions.
|
15982448 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders.
|
16026766 |
2005 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
LHGDN |
The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders.
|
16026766 |
2005 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population.
|
16395129 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our findings did not confirm the association of AKT1 SNP2/3/4 TCG haplotype with the risk of schizophrenia as reported in the original study but showed the evidence of association with a different haplotype, AKT1 five-SNP AGCAG haplotype, with the risk of schizophrenia in Iranian population.
|
16583435 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
For other genes, disrupted in schizophrenia (DISC1), D-amino acid oxidase activator (DAOA), regulator of G-protein signalling 4 (RGS4) and V-AKT murine thymoma viral oncogene homolog 1 (AKT1) the data are promising but not yet compelling.
|
16612196 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects.
|
16987250 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
LHGDN |
A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects.
|
16987250 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Recent investigations suggest that the AKT/glycogen synthase kinase 3 (GSK3) signaling cascade may be associated with the pathophysiology of schizophrenia and methamphetamine (METH) use disorder.
|
17233643 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Thus, our study does not indicate that AKT1 or DTNBP1 play a role in the etiology of schizophrenia in the Finnish population.
|
17300918 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.Nat.Genet.
|
17383860 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
LHGDN |
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.Nat.Genet.
|
17383860 |
2007 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the association of genetic variation in AKT1 with neurocognition was investigated in patients with schizophrenia.
|
17464696 |
2007 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Exploratory haplotype analysis confirmed association with schizophrenia toward the 5' end of AKT1 (.008 < p < .049, uncorrected).
|
17825267 |
2008 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our study suggests that AKT1 is a susceptibility gene for schizophrenia in the Chinese population and that the AKT1 gene may play no major role in the therapeutic response to antipsychotics or in chlorpromazine-induced extrapyramidal syndrome.
|
17915974 |
2007 |