|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects.
|
16987250 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
LHGDN |
A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects.
|
16987250 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
MGD |
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.
|
11533044 |
2001 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
MGD |
Consistent with this proposal, we also show that haloperidol induces a stepwise increase in regulatory phosphorylation of AKT1 in the brains of treated mice that could compensate for an impaired function of this signaling pathway in schizophrenia.
|
14745448 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Consistent with this proposal, we also show that haloperidol induces a stepwise increase in regulatory phosphorylation of AKT1 in the brains of treated mice that could compensate for an impaired function of this signaling pathway in schizophrenia.
|
14745448 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
Consistent with this proposal, we also show that haloperidol induces a stepwise increase in regulatory phosphorylation of AKT1 in the brains of treated mice that could compensate for an impaired function of this signaling pathway in schizophrenia.
|
14745448 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.Nat.Genet.
|
17383860 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
LHGDN |
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.Nat.Genet.
|
17383860 |
2007 |
|
Schizophrenia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.
|
27484635 |
2016 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Exploratory haplotype analysis confirmed association with schizophrenia toward the 5' end of AKT1 (.008 < p < .049, uncorrected).
|
17825267 |
2008 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples.
|
15982448 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
For other genes, disrupted in schizophrenia (DISC1), D-amino acid oxidase activator (DAOA), regulator of G-protein signalling 4 (RGS4) and V-AKT murine thymoma viral oncogene homolog 1 (AKT1) the data are promising but not yet compelling.
|
16612196 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Genetic linkage and association studies have identified Akt-1 as a candidate susceptibility gene related for schizophrenia.
|
22771711 |
2012 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
|
23246288 |
2013 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
However, minuscule data exist on the role of different alleles of AKT1 in measurable quantitative endophenotypes, such as cognitive abilities and neuroanatomical features, showing deviations in schizophrenia and bipolar disorder.
|
19051289 |
2009 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings, by showing the involvement of the AKT1 gene in both schizophrenia and bipolar disorder, support the role of AKT1 in the genetics of both disorders and add support to the view that there is some genetic overlap between them.
|
20214684 |
2010 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions.
|
15982448 |
2006 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In support of this hypothesis, we reported that the V-act murine thymoma viral oncogene homologue 1 (AKT1) gene was associated with METH-induced psychosis and schizophrenia in the Japanese population.
|
19747927 |
2010 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In the context of anti-psychotic drugs, the DRD2 and AKT1 polymorphisms altered dose-response effects of anti-psychotic drugs on cognition in schizophrenia (n = 111).
|
22525159 |
2012 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In this study, our aim was to determine whether AKT1 gene variants are associated with particular phenotypes for schizophrenia (SCZ) and bipolar disorder (BPD).
|
22277669 |
2012 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Many susceptible genes have been identified in schizophrenia such as catechol-O-methyltransferase (COMT) and serine/threonine kinase (AKT1).
|
25801838 |
2015 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity.
|
15581715 |
2005 |
|
Schizophrenia
|
0.900 |
PosttranslationalModification
|
disease |
BEFREE |
Neuregulin 1-induced AKT phosphorylation in monozygotic twins discordant for schizophrenia.
|
20371257 |
2010 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis.
|
23747160 |
2013 |