|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
(2) The human homolog of int-2, located on chromosome 11q13, is frequently amplified in human primary tumors and is comprised in an amplification unit encompassing the hst gene, which is often coamplified; the amplification at the 11q13 locus in breast carcinomas correlates with a poor outcome of the disease.
|
2677918 |
1989 |
|
Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.
|
2856253 |
1988 |
|
Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
A comparative genomic hybridization analysis using one frozen HCC sample from a responder demonstrated that the 11q13 region, a rare amplicon in HCC including the loci for FGF3 and FGF4, was highly amplified.
|
22890726 |
2013 |
|
Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Through hybridization with known oncogene probes, the transforming gene in one hepatoma was found to be the human hst gene.
|
2824415 |
1987 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Survival rates for patients bearing tumors with and without hst-1 gene amplification were calculated by the Kaplan-Meier method and evaluated by the log-rank test.
|
8010723 |
1994 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
HST/HER2 ratios did not predict the presence of HST protein, which was found in 46 (25%) of 187 tumors.
|
18592003 |
2008 |
|
Malignant Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer.
|
3290903 |
1988 |
|
Carcinoma
|
0.060 |
GeneticVariation
|
group |
BEFREE |
No coamplification of the hst-1 and int-2 genes was detected in gastric carcinomas and colorectal carcinomas.
|
2529025 |
1989 |
|
Carcinoma
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Concerning band q13: (i) 50 tumors (approximately 17%) were co-amplified for BCL-1, HST & INT-2; (ii) in 3 cases, amplification extended to the SEA gene; (iii) in 6 carcinomas, BCL-1 was the only amplified marker.
|
2181375 |
1990 |
|
Primary malignant neoplasm
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer.
|
3290903 |
1988 |
|
Esophageal carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
High amplification of the hst-1 gene correlates with haematogenous recurrence after curative resection of oesophageal carcinoma.
|
7796011 |
1995 |
|
Esophageal carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Intratumoral heterogeneity of hst-1 gene amplification in esophageal carcinoma with reference to DNA stem line heterogeneity.
|
8523818 |
1995 |
|
Squamous cell carcinoma of esophagus
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Amplification of 11q13.3 (FGF4) and deletion of 9p21.3 (CDKN2A) were found to be recurrent in all 38 superficial ESCCs analyzed.
|
27974698 |
2017 |
|
Carcinogenesis
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
These results suggest that amplification of chromosomal locus of the hst-1 and int-2 genes might participate in carcinogenesis, in progression, and particularly in metastasis of esophageal carcinomas.
|
2529025 |
1989 |
|
Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
However, no amplification of the hst-1 gene was detected in gastric and colorectal carcinomas.
|
3136110 |
1988 |
|
Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
No coamplification of the hst-1 and int-2 genes was detected in gastric carcinomas and colorectal carcinomas.
|
2529025 |
1989 |
|
Craniosynostosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
An 11q11-q13.3 duplication, including FGF3 and FGF4 genes, in a patient with syndromic multiple craniosynostoses.
|
17632770 |
2007 |
|
Craniosynostosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Clinical comparison of our patient with those previously reported with overlapping 11q duplications allows us to define the minimal duplicated region associated with craniosynostosis and strongly supports the hypothesis that the constitutional increased dosage of the FGF3 and FGF4 genes is a risk factor for craniosynostosis in humans.
|
24120895 |
2014 |
|
leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Restriction map of the hst gene from normal leukocyte DNA was identical with that from leukocyte DNA of a leukemia patient, while the hst gene from T361-2nd-1 cells was rearranged at the 168th nucleotide upstream of the TATA box.
|
2895649 |
1988 |
|
leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our laboratory previously described the independent isolation of the fibroblast growth factor 4 (FGF-4) gene by NIH3T3 transformation assay using DNA from a patient with CML leukemia (Lucas et al., 1994).
|
9050999 |
1997 |
|
Malignant neoplasm of esophagus
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Amplification of the hst-1 and int-2 genes on chromosome 11q13 has previously been found in over 20% of human primary esophageal cancers.
|
1533816 |
1992 |
|
Malignant neoplasm of esophagus
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The finding that sevenfold or greater amplification of the hst-1 gene seems to be associated with haematogenous recurrence of oesophageal cancer after resection may serve to assess the clinical outcome.
|
7796011 |
1995 |
|
Germ Cell Cancer
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A subset of male germ cell cancers presenting with advanced stage abundantly express the fibroblast growth factor-4 (FGF4).
|
9715278 |
1998 |
|
Childhood Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Restriction map of the hst gene from normal leukocyte DNA was identical with that from leukocyte DNA of a leukemia patient, while the hst gene from T361-2nd-1 cells was rearranged at the 168th nucleotide upstream of the TATA box.
|
2895649 |
1988 |
|
Childhood Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our laboratory previously described the independent isolation of the fibroblast growth factor 4 (FGF-4) gene by NIH3T3 transformation assay using DNA from a patient with CML leukemia (Lucas et al., 1994).
|
9050999 |
1997 |