|
Breast Carcinoma
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of breast
|
0.560 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Neoplasm of uncertain or unknown behavior of breast
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast adenocarcinoma
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of esophagus
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Amplification of the hst-1 and int-2 genes on chromosome 11q13 has previously been found in over 20% of human primary esophageal cancers.
|
1533816 |
1992 |
|
Esophageal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Here, we report coamplification of the cyclin D and hst-1 genes in 5 of 20 (25%) human squamous esophageal tumors.
|
1533816 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant association between tumor stage and hst-1 expression in the nonseminoma group was found (P = 0.0002, chi 2 test).
|
1706218 |
1991 |
|
Germ cell tumor
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
There were significant differences in oncogene expression between seminomas and nonseminomas with c-kit being expressed in 24 of 30 (80%) seminomas but in only 3 of 40 (7%) nonseminomatous tumors (P = 0.0001, chi 2 test) and hst-1 being expressed in 24 of 38 (63%) nonseminomas but only 1 of 24 (4%) of seminomas (P = 0.0001, chi 2 test), demonstrating an inverse relationship in the expression pattern of these 2 oncogenes in human testicular germ cell tumors.
|
1706218 |
1991 |
|
Seminoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
There were significant differences in oncogene expression between seminomas and nonseminomas with c-kit being expressed in 24 of 30 (80%) seminomas but in only 3 of 40 (7%) nonseminomatous tumors (P = 0.0001, chi 2 test) and hst-1 being expressed in 24 of 38 (63%) nonseminomas but only 1 of 24 (4%) of seminomas (P = 0.0001, chi 2 test), demonstrating an inverse relationship in the expression pattern of these 2 oncogenes in human testicular germ cell tumors.
|
1706218 |
1991 |
|
testicular nonseminoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A significant association between tumor stage and hst-1 expression in the nonseminoma group was found (P = 0.0002, chi 2 test).
|
1706218 |
1991 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The glutathione S-transferase gene (GST pi) is located on the same chromosome band (11q13) as proto-oncogenes INT2 and HSTF1 which are frequently amplified in breast cancer.
|
1826346 |
1991 |
|
Malignant neoplasm of breast
|
0.560 |
Biomarker
|
disease |
BEFREE |
GST pi gene is frequently coamplified with INT2 and HSTF1 proto-oncogenes in human breast cancers.
|
1826346 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Coamplification of GST pi, HSTF1 and INT2 was observed in five tumors, and coamplification of GST pi and HSTF1 without amplification of INT2 in another tumor.
|
1826346 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast to controls, K-fgf-transfected cells secrete significant amounts of biologically active K-fgf protein into the growth media, show up to 50-fold increased colony formation in soft agar, and grow into rapidly progressing, highly vascularized tumors in athymic nude mice.
|
1964794 |
1990 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that int-2/hst-1 coamplification is a new biological indicator of prognosis and distant organ metastasis in patients with esophageal squamous cell carcinoma.
|
1997190 |
1991 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Significance of int-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma.
|
1997190 |
1991 |
|
Squamous cell carcinoma of esophagus
|
0.040 |
Biomarker
|
disease |
BEFREE |
These results suggest that int-2/hst-1 coamplification is a new biological indicator of prognosis and distant organ metastasis in patients with esophageal squamous cell carcinoma.
|
1997190 |
1991 |
|
Teratocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differentiation associated modulation of K-FGF expression in a human teratocarcinoma cell line and in primary germ cell tumours.
|
2009969 |
1991 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, known genes within the amplified region, such as the FGF-related oncogenes INT-2 and HST-1, are very rarely expressed in these tumors.
|
2011398 |
1991 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
BCL1 and two proto-oncogenes, INT2 and HST, were previously found to be coamplified in approximately 1/5 breast carcinomas.
|
2071147 |
1991 |
|
Carcinoma
|
0.060 |
Biomarker
|
group |
BEFREE |
The telomeric one includes the D11S146/BCL1/INT2/HST area and is relevant to DNA amplification in carcinomas and to B-cell translocations.
|
2071147 |
1991 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
HST-1 and INT-2 genes which is a member of fibroblast growth factor gene family, are amplified in approximately 50% of primary tumors and all the metastatic tumors of esophageal carcinomas.
|
2098274 |
1990 |
|
Carcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
HST-1 and INT-2 genes which is a member of fibroblast growth factor gene family, are amplified in approximately 50% of primary tumors and all the metastatic tumors of esophageal carcinomas.
|
2098274 |
1990 |
|
Germ Cell Cancer
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Hst-1/kFGF and bFGF are commonly expressed in five of seven male germ cell cancer lines.
|
2158037 |
1990 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Only four proto-oncogenes were found to be amplified in at least one tumor each: HST and INT2 (x3), MYC (x2-3), and FES (x greater than 10).
|
2177639 |
1990 |