|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Five clones, containing the genomic hst gene, were isolated from a human cosmid library constructed from leukocyte DNA from a patient with acute leukemia.
|
3030292 |
1987 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study thus shows that FGF4 induces EMT by elevating SOCE in lung ADC.
|
27677589 |
2016 |
|
Adenoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Although hst gene rearrangements and deletions of 11q13 are not associated with sporadic PRL-cell adenoma formation, a single patient was detected with a partial loss of chromosome 11, including the putative MEN-1 site.
|
8100831 |
1993 |
|
Angina Pectoris
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The objectives of the Angiogenic GENe Therapy (AGENT) trial were to evaluate the safety and anti-ischemic effects of 5 ascending doses of Ad5-FGF4 in patients with angina and to select potentially safe and effective doses for subsequent study.
|
11901038 |
2002 |
|
Bladder Neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
None of 37 hematopoietic neoplasms, one out of 13 melanomas (8%), three out of 43 bladder tumors (7%) and 41 out of 238 breast carcinomas (17%) contained amplified FGF-related sequences, namely HST and INT2.
|
2474139 |
1989 |
|
Bladder Neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus cyclin D1 and EMS1, but not FGF3 and FGF4, are likely to play a pathogenic role in the 11q13 amplification in bladder cancer.
|
8622895 |
1996 |
|
Breast adenocarcinoma
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In an attempt to probe the significance of HST and INT-2 gene amplification in human breast carcinomas, we have surveyed the amplification status of five molecular markers located on the long arm of chromosome 11 (BCL-1, HST, INT-2 & SEA on 11q13, and ETS-1 on 11q23) in a population of 297 mammary tumors.
|
2181375 |
1990 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because HST is described as an endogenous pan-HER inhibitor, the presence of this protein in breast carcinomas may portent the inefficiency of exogenous efforts to block HER2 dimerization, whereas its absence may justify such interventions.
|
18592003 |
2008 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The glutathione S-transferase gene (GST pi) is located on the same chromosome band (11q13) as proto-oncogenes INT2 and HSTF1 which are frequently amplified in breast cancer.
|
1826346 |
1991 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The CCND1-FGF19-FGF4-FGF3 gene cluster in human chromosome 11q13 is amplified in breast cancer, squamous cell carcinoma of head and neck, and bladder tumors, and is also translocated in parathyroid tumors and B-cell lymphoma.
|
12429977 |
2002 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
(2) The human homolog of int-2, located on chromosome 11q13, is frequently amplified in human primary tumors and is comprised in an amplification unit encompassing the hst gene, which is often coamplified; the amplification at the 11q13 locus in breast carcinomas correlates with a poor outcome of the disease.
|
2677918 |
1989 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.
|
8481921 |
1993 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although evaluation of the clinical significance of HST amplification and expression must await long-term follow-up of the patients, we suggest that HST gene product could play a role in development and/or progression of human breast cancer.
|
2474139 |
1989 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Other members of the fibroblast growth factor family have been either not expressed in the human breast (FGF3, FGF4) or have been found at much reduced levels in breast cancer (FGF1, FGF2) and this is the first member of the family to potentially influence the progression of breast cancer through stimulation of cell division.
|
9184170 |
1997 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, overexpressing OCT3 stimulated endogenous FGF-4 expression in MCF7 breast cancer cell line.
|
12841847 |
2003 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
|
21936542 |
2011 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mechanisms, including ras activation, fibroblast growth factor 4 expression, and human DNA methyltransferase activation causing ER promoter methylation, which are respectively known to induce estrogen-independent growth, induce spontaneous metastasis, and decrease ER levels in breast carcinoma experimentally, were not mechanisms operating in the hybrids.
|
8758927 |
1996 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
BCL1 and two proto-oncogenes, INT2 and HST, were previously found to be coamplified in approximately 1/5 breast carcinomas.
|
2071147 |
1991 |
|
Breast Carcinoma
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
To elucidate the role of hst in pituitary tumorigenesis we treated primary rat pituitary and pituitary tumor cell cultures with recombinant FGF-4 and also stably transfected pituitary cell lines with full-length human hst cDNA.
|
8550832 |
1996 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Although hst-1 and int-2 are usually not expressed despite amplification, elevated transcription of the cyclin D gene is accompanied by its amplification, suggesting a role of a G1 cyclin in oesophageal carcinogenesis.
|
8095412 |
1993 |
|
Carcinogenesis
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
These results suggest that amplification of chromosomal locus of the hst-1 and int-2 genes might participate in carcinogenesis, in progression, and particularly in metastasis of esophageal carcinomas.
|
2529025 |
1989 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
These observations indicate that OCT3 protein is selectively expressed in human breast cancer cells, and its expression may be implicated in mammary gland tumorigenesis via up-regulating FGF-4 expression.
|
12841847 |
2003 |
|
Carcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Amplification of the hst-1 gene in human esophageal carcinomas.
|
3136110 |
1988 |