|
Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Gastro-esophageal reflux disease (GERD) may occur post-achalasia intervention due to disruption of the LES and therefore requires diligent follow-up, especially in children treated with POEM.
|
29439587 |
2018 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genomic analysis showed that two variations localized in FUT3 promoter region are possibly associated with IDC.
|
26321244 |
2015 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of FUT3 is linked to poor prognosis in clear cell renal cell carcinoma.
|
28977844 |
2017 |
|
Major Depressive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, after controlling for depression severity, significant differences between Q-LES-Q and Zung-SAS scores disappeared in MDD and BP.
|
30292023 |
2019 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, after controlling for depression severity, significant differences between Q-LES-Q and Zung-SAS scores disappeared in MDD and BP.
|
30292023 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of FUT3 and FUT6 in augmenting the malignant potential of CRC induced by TGF-β is unclear.
|
24253505 |
2014 |
|
Esophagitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
HR-Manometry showed a similar reduction in the LES pressure and 4sIRP; 24-h pH-monitoring showed however an abnormal exposure to acid in 38.4% of POEM patients, as compared to 17.1% of LHD patients (p < 0.01) and esophagitis was found in 37.4% of the POEM and 15.2% of LHD patients (p < 0.05).
|
31848870 |
2020 |
|
Esophageal Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Increased lower esophageal sphincter integrated relaxation pressure (LES-IRP) is a cardinal feature of achalasia.
|
30153516 |
2019 |
|
Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Increased lower esophageal sphincter integrated relaxation pressure (LES-IRP) is a cardinal feature of achalasia.
|
30153516 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum LDL cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Infection
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Lewis enzyme (alpha1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population.
|
12730721 |
2003 |
|
Pancreatic carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Lewis genotypes were determined in a large cohort of patients with pancreatic cancer (682 cases) and controls (525 cases) by sequencing the Fucosyltransferase 3 (FUT3) gene from genomic DNA.
|
28267695 |
2017 |
|
Malignant neoplasm of pancreas
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Lewis genotypes were determined in a large cohort of patients with pancreatic cancer (682 cases) and controls (525 cases) by sequencing the Fucosyltransferase 3 (FUT3) gene from genomic DNA.
|
28267695 |
2017 |
|
Deglutition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Longer myotomy on the gastric side (>2.5 cm) ensures complete division of the LES with better outcomes in term of resolution of dysphagia but may be associated with higher postoperative GERD.
|
31012870 |
2019 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, LES-LAPG may be advantageous for anemia prevention and nutritional status improvement compared to LAPG-DTA.
|
30591490 |
2019 |
|
Herpes Simplex Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Moreover, inhibition of NFκB signaling through panepoxydone treatment significantly decreased the induction of FUT3, FUT5 and FUT6 transcriptional activation, as did siRNA targeting of p65, in herpes simplex virus type 1 infected fibroblasts.
|
28973293 |
2017 |
|
Cystic Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Nevertheless, highest resistance was documented for the nonmutator CF epidemic strain LES-1 (ST-146) detected for the first time in Spain.
|
23951065 |
2013 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
None of the individual variants surpassed a Bonferroni corrected p-value cutoff of 0.0016; however, after a gene-based permutation test, two loci [FUT3(Le)/FUT5/FUT6 and FUT2(Se)] were significantly associated with diffuse- and intestinal-type GC, respectively.
|
24947433 |
2015 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
None of the individual variants surpassed a Bonferroni corrected p-value cutoff of 0.0016; however, after a gene-based permutation test, two loci [FUT3(Le)/FUT5/FUT6 and FUT2(Se)] were significantly associated with diffuse- and intestinal-type GC, respectively.
|
24947433 |
2015 |
|
Gastroesophageal reflux disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Numerous studies demonstrate that POEM produces comparable, if not superior, results compared to standard laparoscopic Heller myotomy (LHM), as determined by LES pressure, dysphagia frequency, Eckardt score, hospital length of stay, therapy durability, and incidence of GERD.
|
31451984 |
2020 |