Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our identified BIK interactive total feedback molecular network showed FUT3 [fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase Lewis blood group)], PMM2 (phosphomannomutase 2), SQSTM1 (sequestosome 1), SFN_2 [REX2 RNA exonuclease 2 homolog (S. cerevisiae)] and ZNF384 (zinc finger protein 384) in low normal adjacent tissues of lung adenocarcinoma.
|
26423071 |
2016 |
Crohn Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study aimed to analyze associations of CD with FUT2 and FUT3 polymorphisms in Chinese population.
|
24720527 |
2014 |
Secondary malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overexpressed N-fucosylation on the cell surface driven by FUT3, 5, and 6 promotes cell motilities in metastatic pancreatic cancer cell lines.
|
30808544 |
2019 |
Cystic Fibrosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the genes encoding ABO blood type, secretor or Lewis genotypes were not shown to associate with severity of CF lung disease, or age of onset of P. aeruginosa infection, nor was there any association with other clinical phenotypes in a group of 808 patients homozygous for the DeltaF508 mutation.
|
19169360 |
2009 |
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease.
|
17383304 |
2007 |
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease.
|
17383304 |
2007 |
Coronary Artery Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease.
|
17383304 |
2007 |
Colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Similar conclusions were drawn for the mutant allele (A) and genotype (GA+AA) of FUT3 (rs3745635) in patients with extensive colitis compared to those with distal colitis (P = 0.006, 95%CI: 0.553-0.845; P = 0.011, 95%CI: 0.621-0.900, respectively).
|
26766790 |
2016 |
Distal colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Similar conclusions were drawn for the mutant allele (A) and genotype (GA+AA) of FUT3 (rs3745635) in patients with extensive colitis compared to those with distal colitis (P = 0.006, 95%CI: 0.553-0.845; P = 0.011, 95%CI: 0.621-0.900, respectively).
|
26766790 |
2016 |
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
LHGDN |
Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma.
|
11819805 |
2001 |
Hiatal Hernia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The A factor (the degree of hiatal hernia), P factor (the degree of esophagitis), and pH < 4 holding time significantly improved after surgery compared with prior to surgery (p < 0.001 for all), while the LES lengths and abdominal LES lengths were extended (p < 0.001 for each).
|
30225741 |
2018 |
Esophagitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The A factor (the degree of hiatal hernia), P factor (the degree of esophagitis), and pH < 4 holding time significantly improved after surgery compared with prior to surgery (p < 0.001 for all), while the LES lengths and abdominal LES lengths were extended (p < 0.001 for each).
|
30225741 |
2018 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
The authors stably transfected human lung carcinoma cell lines with the FucT-III gene and exposed them to TNF-α to investigate its role in regulation of sLeX expression and selectin-binding ability using semiquantitative real-time polymerase chain reaction and flow cytometry.
|
21437888 |
2011 |
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The current results indicated that neutrophils may be recruited to areas of FucT-III activity and sLeX expression in lung carcinomas to enhance the invasive and metastatic potential of lung cancer cells.
|
21437888 |
2011 |
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The current results indicated that neutrophils may be recruited to areas of FucT-III activity and sLeX expression in lung carcinomas to enhance the invasive and metastatic potential of lung cancer cells.
|
21437888 |
2011 |
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The current results indicated that neutrophils may be recruited to areas of FucT-III activity and sLeX expression in lung carcinomas to enhance the invasive and metastatic potential of lung cancer cells.
|
21437888 |
2011 |
Ulcerative Colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of mutant allele (A) and genotype (GA+AA) in FUT3 (rs3745635) were higher in UC patients than controls (P = 0.016, 95%CI: 1.339-1.699; P = 0.038, 95%CI: 1.330-1.742, respectively).
|
26766790 |
2016 |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
The human alpha-1,3/4 fucosyltransferase III (FucT III) catalyses the synthesis of Lewis antigens including Le(b) antigen which is a ligand for Helicobacter pylori adhesion.
|
12730721 |
2003 |
Gastroesophageal reflux disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The majority of patients who undergo a laparoscopic fundoplication for gastroesophageal reflux disease (GERD) have a structural (hiatal hernia, shortened lower esophageal sphincter [LES]) or functional (weak LES) defect of the gastroesophageal junction (GEJ).
|
31214803 |
2020 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The non-expression of FUT3 was more frequent in larger lesions and also in HER2 negative IDC tumors.
|
26321244 |
2015 |
Gastroesophageal reflux disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
The resting LES pressure was 8.9±5.94 mmHg with GER symptoms, 16.4±12.79 mmHg without GER symptoms, and 26.8±14.03 mmHg with achalasia.
|
29915812 |
2018 |
Esophageal Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
The resting LES pressure was 8.9±5.94 mmHg with GER symptoms, 16.4±12.79 mmHg without GER symptoms, and 26.8±14.03 mmHg with achalasia.
|
29915812 |
2018 |
Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
The resting LES pressure was 8.9±5.94 mmHg with GER symptoms, 16.4±12.79 mmHg without GER symptoms, and 26.8±14.03 mmHg with achalasia.
|
29915812 |
2018 |
Impulsive Behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The Screen for Gambling Problems (NODS), Quality of Life Enjoyment and Satisfaction (Q-LES-Q), Impulsive Behavior Scale (UPPS-P), Sheehan Disability Inventory (SDI), Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) were administered pre- and posttreatment.
|
29353301 |
2018 |
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The strong correlation between the promoter activity of the FUT III gene and the high expression of sialyl Le(a) observed in different colon carcinoma cell lines seem to confirm the important regulatory role of FUT3 in the synthesis of sialyl Le(a).
|
16199102 |
2005 |