|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Although immunization with GAD65 did not produce any behavioral abnormality in the mice, the induction of neuronal-surface antibodies and the trend towards loss of GABAergic neurons in the brainstem, supports a role for humoral autoimmunity in the pathogenesis of SPS and suggests that the mechanisms may involve spread to antigens expressed on the surface of these neurons.
|
24058450 |
2013 |
|
Absence Seizures
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures.
|
8985701 |
1996 |
|
Absence Seizures
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures.
|
8954991 |
1996 |
|
Addison Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Lymphocytes from a patient with Addison's disease who had GAD65 autoantibodies without diabetes were immortalised and fused to a mouse/human hybridoma.
|
12515289 |
2002 |
|
Agnosia for Pain
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia.
|
19656360 |
2009 |
|
AICARDI-GOUTIERES SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, infection of CNIC with GAD65 antisense virus resulted in 100% incidence of wild running and clonus behaviors in AGS animals.
|
27993512 |
2017 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
Biomarker
|
disease |
BEFREE |
Analyses in these populations did not support a role for GAD2 in alcoholism.
|
17034009 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
Biomarker
|
disease |
BEFREE |
There are two isoforms of GAD, GAD1 and GAD2, which were reported to be associated with AD in males of Han Taiwanese (GAD1) and Russian (GAD2) ancestry.
|
19111404 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Three valid SNPs at the GAD2 gene demonstrated no associations with alcoholism.
|
17067345 |
2006 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present work focuses on the early stage of disease progression and uses TgF344-AD rats that recapitulate a broad repertoire of AD-like pathologies to investigate the neuronal network functioning using simultaneous intracranial recordings from the hippocampus (HPC) and the medial prefrontal cortex (mPFC), followed by pathological analyses of gamma-aminobutyric acid (GABA<sub>A</sub> ) receptor subunits α1<sub>,</sub> α5, and δ, and glutamic acid decarboxylases (GAD65 and GAD67).
|
28777881 |
2018 |
|
Amnesia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We describe a patient who presented with progressive memory loss 2 weeks after her third cycle of Ipilimumab and Nivolumab with associated elevated Anti-GAD65 levels.
|
31832829 |
2020 |
|
Anemia, Pernicious
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Type 1 diabetes, autoimmune thyroid disease, and pernicious anemia are the most frequent GAD65 autoimmune associations.
|
28063151 |
2017 |
|
Anxiety
|
0.080 |
Biomarker
|
disease |
BEFREE |
VAs were not significantly associated with the progression of symptoms of depression (adjusted relative risk [aRR] = 1.29, 95% confidence interval [CI] = 0.94-1.77) and anxiety (aRR = 1.22, 95% CI = 0.86-1.72), or with change in average scores of PHQ-2 and GAD-2 over time, both before and after risk adjustment.
|
30482494 |
2019 |
|
Anxiety
|
0.080 |
Biomarker
|
disease |
BEFREE |
FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like.
|
25106036 |
2014 |
|
Anxiety
|
0.080 |
Biomarker
|
disease |
BEFREE |
Based on the rigorous standard suggested by the Quality Assessment of Diagnostic Accuracy Studies-2, a total of 1,157 participants randomly recruited from the community completed the GAD-7, GAD-2, and other anxiety and depression measures in a counter-balanced order.
|
30936840 |
2019 |
|
Anxiety
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Parental depression and anxiety were screened with the Patient Health Questionnaire-2 (PHQ-2) and Generalized Anxiety Disorder Scale-2 (GAD-2).
|
31222745 |
2019 |
|
Anxiety
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
A random sample of 688 undergraduate university students (mean age = 20.64 ±1.88 years; 53% men) completed a survey composed of a) questions about socio-demographics, academics, lifestyle behaviors, personality type, and smartphone use-related variables; b) 26-item Smartphone Addiction Inventory (SPAI) Scale; and c) brief screeners of depression and anxiety (PHQ-2 and GAD-2), which constitute the two core DSM-IV items for major depressive disorder and generalized anxiety disorder, respectively.
|
28777828 |
2017 |
|
Anxiety
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the association of PC-related anxiety (MAX-PC) with sociodemographic characteristics, family history of PC, global health status/quality of life (EORTC QLQ-C30), depression and anxiety (PHQ-2; GAD-2), latest PSA level, time since radical prostatectomy, and current therapy.
|
28528448 |
2017 |
|
Anxiety
|
0.080 |
Biomarker
|
disease |
BEFREE |
The Generalized Anxiety Disorder Scales GAD-7 and GAD-2 are instruments for the assessment of anxiety.
|
28088111 |
2017 |
|
Anxiety
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
These results support earlier studies that suggest associations of polymorphisms within the GAD2 locus with anxiety and affective disorders.
|
19229853 |
2009 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A random sample of 688 undergraduate university students (mean age = 20.64 ±1.88 years; 53% men) completed a survey composed of a) questions about socio-demographics, academics, lifestyle behaviors, personality type, and smartphone use-related variables; b) 26-item Smartphone Addiction Inventory (SPAI) Scale; and c) brief screeners of depression and anxiety (PHQ-2 and GAD-2), which constitute the two core DSM-IV items for major depressive disorder and generalized anxiety disorder, respectively.
|
28777828 |
2017 |
|
Anxiety Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
VAs were not significantly associated with the progression of symptoms of depression (adjusted relative risk [aRR] = 1.29, 95% confidence interval [CI] = 0.94-1.77) and anxiety (aRR = 1.22, 95% CI = 0.86-1.72), or with change in average scores of PHQ-2 and GAD-2 over time, both before and after risk adjustment.
|
30482494 |
2019 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We evaluated the association of PC-related anxiety (MAX-PC) with sociodemographic characteristics, family history of PC, global health status/quality of life (EORTC QLQ-C30), depression and anxiety (PHQ-2; GAD-2), latest PSA level, time since radical prostatectomy, and current therapy.
|
28528448 |
2017 |
|
Anxiety Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Glutamate decarboxylases (GAD67/65; GAD1/GAD2) are crucially involved in gamma-aminobutyric acid (GABA) synthesis and thus were repeatedly suggested to play an important role in the pathogenesis of anxiety disorders.
|
23906988 |
2013 |
|
Anxiety Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The Generalized Anxiety Disorder Scales GAD-7 and GAD-2 are instruments for the assessment of anxiety.
|
28088111 |
2017 |