Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
We used dual-label in situ hybridization to quantify GABA(A) α1 subunit mRNA expression in calcium/calmodulin-dependent kinase II α (CaMKIIα)-containing pyramidal cells and glutamic acid decarboxylase 65 kDa (GAD65)-containing interneurons in layer 3 of the PFC from matched schizophrenia and healthy comparison subjects.
|
21677653 |
2011 |
Schizophrenia
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
In concert with previous studies, these findings suggest that schizoaffective disorder is associated with lower levels of both GAD65 and GAD67 mRNA and protein in the PFC, whereas subjects with schizophrenia have lower mean levels of only GAD67 mRNA and protein.
|
24993056 |
2015 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
These results suggest that GAD2 and GLUL do not play a major role in schizophrenia pathogenesis and there is no gene-gene interaction between the eight genes in the Japanese population.
|
19125103 |
2009 |
Schizophrenia
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Although the levels of GAD65 and GAD67 messages were increased in schizophrenia subjects, the proportion of the two GAD isoforms remained constant in controls and schizophrenics.
|
15114630 |
2004 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
Meta-analysis established that the pooled prevalence of GAD65 autoantibodies was 5.8% (95% confidence interval [CI]: 2.0-15.6%; I<sup>2</sup> = 91%; nine studies) in psychotic disorders, with a prevalence of 4.6% (95%CI: 1.2-15.9%; nine studies; I<sup>2</sup> = 89%) and 6.2% (95%CI: 1.2-27.0%; two studies; I<sup>2</sup> = 69%) in schizophrenia and bipolar disorder, respectively.
|
28573688 |
2017 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Using the multifactor-dimensionality reduction method (MDR), we found that the interactions among the rs187269C/T polymorphism in the GABRB2 gene, the -243A/G polymorphism in the GAD2 gene and the 27379C/T and 661C/T polymorphisms in the GAD1 gene revealed a significant association with schizophrenia (P<0.001).
|
17412563 |
2007 |
Schizophrenia
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the patients with schizophrenia with completed suicide or positive nicotine exposure showed significantly higher expression of GAD2 full length transcript.
|
26848839 |
2016 |
Schizophrenia
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Several of the genes in this network including epigenetic factors histone deacetylase 1 (HDAC1) and death-associated protein 6 (DAXX), the GABAergic enzyme GAD65 as well as the kainate receptor (KAR) subunits GluR6 and 7 show significant changes in expression in this area in SZ.
|
27733539 |
2017 |
Seizures
|
0.340 |
Biomarker
|
phenotype |
BEFREE |
In contrast patients with seizures related to GAD65-antibodies (an intracellular antigen) frequently develop epilepsy and have suboptimal response to treatment (including surgery).
|
28234800 |
2017 |
Seizures
|
0.340 |
Biomarker
|
phenotype |
BEFREE |
Enhanced susceptibility to stress and seizures in GAD65 deficient mice.
|
29377906 |
2018 |
Seizures
|
0.340 |
GeneticVariation
|
phenotype |
BEFREE |
Using both a tagging and functional single nucleotide polymorphism (SNP) approach, we genotyped the GAD1 and GAD2 genes and linked them with PTS data, regarding time to first seizure, obtained for 257 adult subjects with severe TBI.
|
22840783 |
2013 |
Seizures
|
0.340 |
Biomarker
|
phenotype |
BEFREE |
Three of the seven patients with LE with different antibodies (NMDAR: n=1, Ma-2/Ta: n=1 and GAD65: n=1) achieved persistent seizure freedom along with no accelerated memory decline after surgery.
|
29253681 |
2018 |
Alcoholic Intoxication, Chronic
|
0.330 |
Biomarker
|
disease |
BEFREE |
Analyses in these populations did not support a role for GAD2 in alcoholism.
|
17034009 |
2007 |
Alcoholic Intoxication, Chronic
|
0.330 |
Biomarker
|
disease |
BEFREE |
There are two isoforms of GAD, GAD1 and GAD2, which were reported to be associated with AD in males of Han Taiwanese (GAD1) and Russian (GAD2) ancestry.
|
19111404 |
2009 |
Alcoholic Intoxication, Chronic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Three valid SNPs at the GAD2 gene demonstrated no associations with alcoholism.
|
17067345 |
2006 |
Major Depressive Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
The best cut-off points to obtain high sensitivity values was 3, on both the PHQ-2 (major depressive disorder) and the GAD-2 (generalized anxiety disorder).
|
29549826 |
2018 |
Major Depressive Disorder
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In addition, using quantitative RT-PCR, expression of GAD2 full length and truncated transcripts were measured in the DLPFC of patients with schizophrenia, bipolar disorder and major depression.
|
26848839 |
2016 |
Major Depressive Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
We used real-time quantitative polymerase chain reaction (qPCR) to assess expression levels of two GABA synthesizing enzymes (glutamate decarboxylase; GAD65 and GAD67) and of three markers of GABA neuron subpopulations (PV, CR, SST) in the dorsolateral prefrontal cortex (DLPFC; Brodmann area 9) in triads (n=19) of control subjects and matched subjects with BPD or MDD.
|
21226980 |
2011 |
Mood Disorders
|
0.320 |
Biomarker
|
group |
BEFREE |
GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders.
|
26848839 |
2016 |
Mood Disorders
|
0.320 |
GeneticVariation
|
group |
BEFREE |
These results support earlier studies that suggest associations of polymorphisms within the GAD2 locus with anxiety and affective disorders.
|
19229853 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
To study this, we tested 482 newly diagnosed diabetic probands and 478 healthy siblings from the Danish population-based T1D registry for autoantibodies to ZnT8 (ZnT8A) in addition to GAD65 and IA-2.
|
20836749 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
Epitope profiles of autoantibodies to GAD65 (GADA) in 140 type 1 diabetes, adult-onset diabetes mellitus (AODM), and thyroid diseases (TD) were studied.
|
12865069 |
2003 |
Diabetes Mellitus, Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
Of those, 112 have developed islet autoimmunity (persistent autoantibodies to insulin, GAD65, and/or IA-2), and 47 of these have progressed to type 1 diabetes.
|
19188433 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mice deficient in GAD67, GAD65 or both were used to assess whether GABA is important for islet cell development, and whether GAD65 is required for initiation of insulitis and progression to Type 1 diabetes in the mouse.
|
10422732 |
1999 |
Diabetes Mellitus, Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
³⁵S-GAD65 produced by either pEx9 or pThGAD65 did not differ in binding among the healthy controls and among the type 1 diabetes patients.
|
20670115 |
2011 |