|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
We investigated PTSD and depression severity, plasma cortisol, GR and mineralocorticoid receptor (MR) levels, and methylation status of NR3C1 and NR3C2 promoter regions in 25 women exposed to the Tutsi genocide during pregnancy and their children, and 25 women from the same ethnicity, pregnant during the same period but not exposed to the genocide, and their children.
|
24690014 |
2014 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis.
|
24933348 |
2015 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Bcl1 polymorphism of the glucocorticoid receptor gene and treatment response to milnacipran and fluvoxamine in Japanese patients with depression.
|
25358426 |
2014 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Bcl1 polymorphism of the glucocorticoid receptor gene and treatment response to milnacipran and fluvoxamine in Japanese patients with depression.
|
25358426 |
2014 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to influence glucocorticoid receptor sensitivity, stress response regulation, and depression risk in traumatized subjects, with most consistent findings reported for the functional variant rs1360780.
|
25522420 |
2014 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to influence glucocorticoid receptor sensitivity, stress response regulation, and depression risk in traumatized subjects, with most consistent findings reported for the functional variant rs1360780.
|
25522420 |
2014 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Depression has been linked to dysfunction of the intracellular response system to corticosteroids at the level of the hippocampus (HC) and prefrontal cortex (PFC) with a notable role of the glucocorticoid receptor (GR) and its co-chaperones (FKBP5 and FKBP4).
|
25666308 |
2015 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The externalizing disorders group had significantly lower NR3C1 methylation levels than the lifetime depressive disorder group (p = 0.009) and healthy controls (p = 0.001) This report of lower methylation levels in NR3C1 in externalizing disorders may indicate a mechanism through which the differential development of externalizing disorders as opposed to depressive disorders might occur.
|
25894927 |
2015 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
In this first study in humans to examine the joint effects of prenatal and postnatal environmental exposures, we report that GR gene (NR3C1) 1-F promoter methylation in infants is elevated in the presence of increased maternal postnatal depression following low prenatal depression, and that this effect is reversed by self-reported stroking of the infants by their mothers over the first weeks of life.
|
25942041 |
2015 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Network modeling and animal experiments suggest that these genetic differences in GR-induced transcriptional activation may mediate the risk for depression and other psychiatric disorders by altering a network of functionally related stress-sensitive genes in blood and brain.
|
26050039 |
2015 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Network modeling and animal experiments suggest that these genetic differences in GR-induced transcriptional activation may mediate the risk for depression and other psychiatric disorders by altering a network of functionally related stress-sensitive genes in blood and brain.
|
26050039 |
2015 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The glucocorticoid receptor (GR) gene (NR3C1) has been found to be susceptible to epigenetic modification, specifically DNA methylation, in the context of environmental stress such as early life trauma, which is an established risk for depression later in life.
|
26387521 |
2015 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Epigenetics and the glucocorticoid receptor: A review of the implications in depression.
|
27344028 |
2016 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor gene modulates severity of depression in women with crack cocaine addiction.
|
27397864 |
2016 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Altered DNA methylation (DNAm) levels of hypothalamic-pituitary-adrenal (HPA) axis genes has been associated with exposure to childhood maltreatment (CM) and depression; however, it is unknown whether CM and depression have joint and potentially interacting effects on the glucocorticoid receptor (NR3C1) DNAm.
|
27475889 |
2016 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the context of environmental stress, a functional variant in the glucocorticoid receptor co-chaperone FKBP5 gene has been repeatedly shown to increase risk for psychiatric illness, including depression.
|
27485401 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men.
|
27549215 |
2017 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
The glucocorticoid receptor gene (NR3C1) displayed different methylation patterns in chronic stress and depression.
|
27998510 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The present study shows that depression attenuates the mechanical allodynia and thermal hyperalgesia of neuropathic pain and suggests that altered spinal GR-BDNF-TrkB signaling may be one of the reasons for depression-induced hypoalgesia.
|
28579944 |
2017 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Most studies showed BDNF and NR3C1 gene methylation levels were correlated with depression while the connection of SLC6A4 and depression was conflicting.
|
28645747 |
2017 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent human studies show that DNA methylation changes of hypothesis-driven candidate gene regions, such as the promoter of the glucocorticoid receptor and the serotonin transporter, were associated with maternal depression in peripheral tissue samples of newborns' cord blood, infants' saliva, or adults' peripheral blood.
|
28714605 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
FKBP5 and specific microRNAs via glucocorticoid receptor in the basolateral amygdala involved in the susceptibility to depressive disorder in early adolescent stressed rats.
|
28826069 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The hypo‑level of adrenocorticotropic hormone, noradrenaline and glucocorticoid receptor in serum and hypothalamus of depression‑like rats was enhanced by PHC.
|
28849191 |
2017 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Additionally, a higher NR3C1 methylation level at CpG 2 was associated with depression incidence 2 years later in this population.
|
29432878 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The glucocorticoid receptor is dysfunctional in depression, and it is a direct target of miR-124.
|
29484897 |
2018 |