|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Regulators of glucocorticoid receptor function in an animal model of depression and obesity.
|
29524264 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mothers with depression also had lower NR3C1 than other mothers (p < 0.003) but did not differ in OXTR.
|
29580902 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Combining both models resulted in 22 new and confirmed HSP90-independent NR3C1 inhibitors, providing two scaffolds (i.e., pyrimidine and pyrazolo-pyrimidine), which could potentially be of interest in the treatment of depression (i.e., inhibiting the glucocorticoid receptor (i.e., NR3C1), while leaving its chaperone, HSP90, unaffected).
|
29658791 |
2018 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
APPL2 Tg mice displayed higher GR activity and less capacity of neurogenesis at olfactory system with less olfactory sensitivity than WT mice, indicating that APPL2 could be a potential therapeutic target for depression and olfactory deficits.
|
29675572 |
2018 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Considering possible confounding effects of alcohol and/or depression, we conclude that chronic cocaine use is associated with lower NR3C1 gene expression suggesting possible direct effects of the drug on the biological adaptation of stress-related genes.
|
29761890 |
2019 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that hypermethylation at the NR3C1 exon 1F may occur in depression.
|
29793048 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The noradrenergic system and GR pathway in the locus coeruleus may be involved in the formation of depression concomitant with sleep disturbances.
|
29894769 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results do not support the hypothesis that GR dysregulation is aetiopathogenic in CFS and suggest that current and future endocrine cross-sectional studies in CFS may be vulnerable to the confounding influence of childhood trauma which is likely increased by comorbid depression.
|
29983634 |
2018 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, six glucocorticoid receptor pathway genes (Slc22a5, Aqp1, Stat5a, Ampd3, Plekhf1, and Cyb561) were upregulated in GF mice, and of these only two (Stat5a and Ampd3) were upregulated in LPS-treated mice, whereas the shared gene, Stat5a, was downregulated in "depression microbiota" recipient mice.
|
30194287 |
2018 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrates that the NR3C1 rs41423247 homozygous mutation may be a risk factor for depression.
|
30278546 |
2018 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACS patients with higher NR3C1 1 F exon methylation levels were at higher risk of developing depressive disorder within 2 weeks of ACS.
|
30408722 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We argue that better understanding the long-term effects of developmental stressors on PFC trkB, GR, and related factors may yield insights into risk for chronic, remitting depression and related neuropsychiatric illnesses.
|
30477984 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain.
|
30738183 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Studies investigating Glucocorticoid Receptor (GR/NR3C1) in the brain have primarily focused on the forebrain, however in recent years, the hindbrain has become a region of interest for research into the development of anxiety and depression, though the role of GR signalling in the hindbrain remains poorly characterised.
|
30824750 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The mineralocorticoid receptor (MR)/glucocorticoid receptor balance plays an important role in the pathophysiology of anxiety and depression.
|
30852427 |
2019 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Poisson regression with robust variance adjusted by gender, tobacco use, self-perceived stress, leisure activity, suicidal ideation, low cortisol levels and NR3C1 DNA methylation was performed and predicted risk factors for depression.
|
31731185 |
2020 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Time-group interaction effects were found for several impulsivity scores, SCL-90R Global Severity Index, Paranoid Thoughts, and Depression subscales as well as for NR3C1 expression.
|
31812111 |
2020 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pain and depressive-like behavior were measured over 14 days and brain-derived neurotrophic factor (BDNF; a factor involved in nociception and depression) and glucocorticoid receptor (GR; a stress-related receptor) expression were measured on day 14.
|
31815911 |
2019 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Differential effects of DRN GR deletion in female mice may provide insight into the greater incidence of depression and specific depression symptoms in women.
|
31846734 |
2020 |