|
Carcinoma, Lewis Lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
By applying the in vivo hypoxia model, the results suggest that intermittent hypoxia significantly promotes the metastasis of Lewis lung carcinoma (LLC), accompanied with more CD209+ macrophages infiltrated in primary tumor tissue.
|
25313135 |
2014 |
|
Mucocutaneous Lymph Node Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis for CD209 polymorphisms showed that A/A/G haplotype (P = 0.0002, OR = 1.61) and G/A/G haplotype (P = 0.0365, OR = 1.52) had higher risk of KD as compared with G/G/A haplotype in rs2287886/rs735239/rs735240 pairwise allele analysis.
|
25148534 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that SNPs in DC-SIGN promoter region can be associated to protection for T1DM in the Northeast Brazilian population.
|
25092567 |
2014 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study provides evidence of an association between CD209 and CD209L polymorphisms and TB development in a Brazilian population, suggesting that variations in these genes may influence the protection and susceptibility to infection caused by M. tuberculosis.
|
24874302 |
2014 |
|
Latent Tuberculosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of CD209 and CD209L polymorphisms with tuberculosis infection in a Northeastern Brazilian population.
|
24874302 |
2014 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because the -336A/G SNP (rs4804803) polymorphism in the promoter of CD209 modulates DC-SIGN expression, we investigated the putative association of this polymorphism with DENV infection and its pathogenesis.
|
24797508 |
2014 |
|
Virus Diseases
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Among significant associations found between virus infections and genetic variants, we report for the first time an association of rs4804803 (CD209) A and G variants with susceptibility to HBV infection and spontaneous clearance (p<0.001, OR=3.53, 95% CI 2.155; 5.908, and p<0.001, OR=7.75, 95% CI 4.646-13.114, respectively).
|
24797387 |
2014 |
|
Hepatitis B
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among significant associations found between virus infections and genetic variants, we report for the first time an association of rs4804803 (CD209) A and G variants with susceptibility to HBV infection and spontaneous clearance (p<0.001, OR=3.53, 95% CI 2.155; 5.908, and p<0.001, OR=7.75, 95% CI 4.646-13.114, respectively).
|
24797387 |
2014 |
|
Hepatitis B, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our observation, that deserves further confirmation with other SNPs and populations, underlines the involvement of selected immune polymorphisms, among which those in CD209, in the natural history of both chronic hepatitis B and C.
|
24797387 |
2014 |
|
Tick-Borne Encephalitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Previously, we reported an association between seven single nucleotide polymorphisms (SNPs) in four innate immunity genes (OAS2, OAS3, CD209, and TLR3) and human predisposition to tick-borne encephalitis, caused by a virus from the same Flaviviridae family, in a Russian population.
|
24594345 |
2014 |
|
Hepatitis C, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.
|
24594345 |
2014 |
|
Severe Dengue
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated that the TT genotype of CLEC5A SNP (rs1285933 C>T) is associated with dengue severity (OR=2.25; p=0.03) and that GG genotype of -336G>A DCSIGN (CD209) SNP is associated with protection to severe dengue (OR=0.12; p=0.04).
|
24016730 |
2013 |
|
Tuberculosis, Pulmonary
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that CD209 rs4804803 polymorphism increased the risk of PTB in a sample of Iranian population.
|
23751770 |
2014 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between -336 A/G polymorphism of CD209 and susceptibility to/protection from tuberculosis is inconsistent.
|
23751770 |
2014 |
|
Colorectal Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We show that SNPs in CD209 may affect CRC risk, while a SNP in REG4 may be a useful marker for CRC progression.
|
23650115 |
2013 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results revealed a significantly higher frequency of 'G' allele and 'G/G' genotype of rs2287886 and A-A-G haplotype of CD209 gene in DEN compared to healthy controls [For 'G/G' genotype, P=0.0072, Odds ratio (OR) 2.43; For A-A-G haplotype, P=0.0033, OR 2].
|
23624202 |
2013 |
|
Virus Diseases
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Association of promoter region polymorphisms of CD209 gene with clinical outcomes of dengue virus infection in Western India.
|
23624202 |
2013 |
|
Thrombocytopenia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The results suggest that rs2287886 G/G genotype of CD209 gene is associated with development of dengue requiring hospitalization while A/A genotype of rs735239 is associated with thrombocytopenia in dengue cases.
|
23624202 |
2013 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis suggested that CD209 promoter polymorphisms (-336A/G, -871A/G) were unlikely to substantially contribute to TB susceptibility.
|
22911807 |
2012 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis has indicated that the CD209-336A/G polymorphism may not contribute to susceptibility to TB.
|
22553928 |
2012 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previously the severity and outcome of dengue fever and hepatitis C (diseases caused by viruses from the family Flaviviridae) were associated with the rs4804803 single nucleotide polymorphism (SNP) located in the promoter region of the human CD209 gene.
|
22061615 |
2012 |
|
Virus Diseases
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Previously the severity and outcome of dengue fever and hepatitis C (diseases caused by viruses from the family Flaviviridae) were associated with the rs4804803 single nucleotide polymorphism (SNP) located in the promoter region of the human CD209 gene.
|
22061615 |
2012 |
|
Hepatitis C
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Previously the severity and outcome of dengue fever and hepatitis C (diseases caused by viruses from the family Flaviviridae) were associated with the rs4804803 single nucleotide polymorphism (SNP) located in the promoter region of the human CD209 gene.
|
22061615 |
2012 |
|
Tick-Borne Encephalitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Thus, our results suggest that the CD209 gene promoter region rs2287886 SNP is associated with predisposition to severe forms of TBE in the Russian population.
|
22061615 |
2012 |
|
Tuberculosis, Pulmonary
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we hypothesize that although carriers of CD209 -336A allele are more sensitive to infection with a Beijing strain, a combination of human CD209 -336G allele and M. tuberculosis Beijing genotype leads more frequently to the lethal outcome in pulmonary TB male patients in Russian (Caucasian) population.
|
22027159 |
2012 |