|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that the long (GT)n repeat of HO-1 gene promoter was associated with a higher frequency of gastric adenocarcinoma, and the medium (GT)n repeat might possess protective effect against gastric adenocarcinoma with a lower frequency of lymphovascular invasion in tumors.
|
17520317 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin (IL)-8, heme oxygenase-1 (HO-1), and vascular endothelial growth factor (VEGF) appear to be critically involved in immune responses associated with inflammation, infection and tumor growth.
|
12151344 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have previously identified that heme oxygenase-1 (HO-1, encoded by HMOX1) inhibits MEC tumor growth and modulates the transcriptome of microRNAs.
|
26393425 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It has been shown that HO-1 is susceptible to proteolytic cleavage and translocates to nucleus to facilitate tumor growth and invasion independent of its enzymatic activity.
|
25885228 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase‑1 (HO‑1), which participates in the development of numerous tumors and the sensitivity of these tumors to chemotherapeutic drugs, plays a protective role by modulating oxidative injury.
|
24788892 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo studies confirmed that STAT3 nuclear delimitation was significantly decreased in PC3 tumors overexpressing HO-1 grown as xenografts in nude mice.
|
23226098 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we investigated whether expression of the metabolic gene, heme oxygenase-1 (HO-1) in tumor microenvironment imparts significant effects on prostate cancer progression.We showed that HO-1 is expressed in MARCO-positive macrophages in prostate cancer (PCa) xenografts and human prostate cancers.
|
26418896 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase-1 (HO)-1 is known to be involved in the development and progression of tumors.
|
25876647 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The stress-inducible cytoprotective enzyme heme oxygenase-1 (HO-1) may play a critical role in the growth and metastasis of tumors.
|
21808062 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both TP- and HO-1-positive macrophages could be observed in the stroma in and around tumors in vertical growth melanomas.
|
11011118 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancer tissues revealed marked HO-1 immunoreactivity in tumor cells and in tumor associated immunocytes.
|
15897578 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long-term effects of HO-1 induction included increased CD8<sup>+</sup> T cell infiltration as well as delayed and reduced tumour growth in one-year-old animals.
|
30389969 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accordingly, inhibition of HO-1 can be suggested as a potential therapeutic approach sensitizing tumors to radiation, chemotherapy, or photodynamic therapy.
|
17822372 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, inhibition of HO-1 decreased tumor growth and MVD by suppressing angiogenic factors, particularly VEGF and HIF-1α.
|
21206978 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Likewise, inhibition of HO-1 activity by chronic administration of the HO-1 inhibitor tin protoporphyrin IX to mice reduces RhoAQL-induced tumor growth by 70%.
|
17881360 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Critically, increased carboxyhemoglobin concentrations were present, likely secondary to hemolysis from the tumor and engagement of systemic heme oxygenase-1.
|
24553061 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, the tumor suppressor BRCA1 binds to the HO-1 promoter and modulates HO-1, inducing its protein levels through both the increment of its promoter activity and the induction of its transcriptional activation.
|
26227317 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MicroRNA-1304 is a tumor suppressor and HO-1 is its direct target in NSCLC.
|
27641735 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase-1 (HO-1) potently influences tumor growth and metastasis.
|
22490514 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase-1 (HO-1) correlates with aggressive tumor behavior and chemotherapy resistance in pancreatic cancer (PC).
|
21495030 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we show that TGFβ also promotes genomic instability in the form of DNA double strand breaks (DSB) in cancer cells that lack the tumor suppressor gene <i>RUNX3</i> Loss of RUNX3 resulted in transcriptional downregulation of the redox regulator heme oxygenase-1 (HO-1 or HMOX1).
|
29074538 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression of the pro-survival protein heme oxygenase-1 (HO-1) and loss of the pro-apoptotic tumour suppressor PTEN are common events in prostate cancer (PCA).
|
21381033 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, HMOX1 overexpressing tumors were smaller, less vascularized and oxygenated, and less metastatic.
|
23617628 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We did not observe HO-1 staining in tumor cells, but high HO-1 reactivity was detected in tumor infiltrating macrophages.
|
30813528 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Since 1950, many studies have revealed the role of HMOX1 in reducing the impact of oxidative stress in many types of diseases, such as Alzheimer's disease, heart disease, and the development of tumors.
|
23939757 |
2013 |