|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HMOX1 mRNA expression was significantly higher in patients with higher grade and multiple tumors than in those with lower grade and single tumors (each p <0.05, respectively).
|
21168882 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase-1 (HO-1) correlates with aggressive tumor behavior and chemotherapy resistance in pancreatic cancer (PC).
|
21495030 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase-1 (HO-1) potently influences tumor growth and metastasis.
|
22490514 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase‑1 (HO‑1), which participates in the development of numerous tumors and the sensitivity of these tumors to chemotherapeutic drugs, plays a protective role by modulating oxidative injury.
|
24788892 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase-1 (HO)-1 is known to be involved in the development and progression of tumors.
|
25876647 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A great deal of data has demonstrated the roles of HO-1 in the formation, growth and metastasis of tumors.
|
20518085 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accordingly, inhibition of HO-1 can be suggested as a potential therapeutic approach sensitizing tumors to radiation, chemotherapy, or photodynamic therapy.
|
17822372 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness.
|
28846111 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin.
|
29311669 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As one of antioxidant defense systems, heme oxygenase-1 (HO-1) acts as an essential role in tumor development by offering antioxidant bilirubin to protect cancer cells under stress conditions.
|
30605610 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ATF4-deficient human fibrosarcoma cells were unable to colonize the lungs in a murine model, and reconstitution of ATF4 or HO-1 expression in ATF4-deficient cells blocked anoikis and rescued tumor lung colonization.
|
26011642 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both TP- and HO-1-positive macrophages could be observed in the stroma in and around tumors in vertical growth melanomas.
|
11011118 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancer tissues revealed marked HO-1 immunoreactivity in tumor cells and in tumor associated immunocytes.
|
15897578 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CD4+ CD25+ FoxP3+ T-cell infiltration and heme oxygenase-1 expression correlate with tumor grade in human gliomas.
|
17216339 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Critically, increased carboxyhemoglobin concentrations were present, likely secondary to hemolysis from the tumor and engagement of systemic heme oxygenase-1.
|
24553061 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Growing evidence indicates that heme oxygenase-1 (HO-1) is up-regulated in malignancies and subsequently alters tumor aggressiveness and various cancer-related factors, such as high glucose (HG) levels.
|
25661467 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hence, the results support the anti-apoptotic role of HO-1 induced by NHE1 in the K562R cell line and IM-insensitive CML patients and provide a mechanism by which inducing HO-1 expression via the PKC-β/p38-MAPK pathway may promote tumor resistance to oxidative stress.
|
25802333 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we show that TGFβ also promotes genomic instability in the form of DNA double strand breaks (DSB) in cancer cells that lack the tumor suppressor gene <i>RUNX3</i> Loss of RUNX3 resulted in transcriptional downregulation of the redox regulator heme oxygenase-1 (HO-1 or HMOX1).
|
29074538 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, immunohistochemical analysis of 31 tumor tissues from DLBCL patients [20 of ABC subtype and 11 of germinal center B-cell-like (GCB) subtype] and 11 normal lymph nodes revealed that HO-1 overexpression was characteristic of ABC-DLBCL.
|
27211510 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we investigated whether expression of the metabolic gene, heme oxygenase-1 (HO-1) in tumor microenvironment imparts significant effects on prostate cancer progression.We showed that HO-1 is expressed in MARCO-positive macrophages in prostate cancer (PCa) xenografts and human prostate cancers.
|
26418896 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo studies confirmed that STAT3 nuclear delimitation was significantly decreased in PC3 tumors overexpressing HO-1 grown as xenografts in nude mice.
|
23226098 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, HMOX1 overexpressing tumors were smaller, less vascularized and oxygenated, and less metastatic.
|
23617628 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, inhibition of HO-1 decreased tumor growth and MVD by suppressing angiogenic factors, particularly VEGF and HIF-1α.
|
21206978 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased HMOX1 levels were detected only in CSIII tumors and may represent a molecular marker of this stage.
|
16906285 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, the tumor suppressor BRCA1 binds to the HO-1 promoter and modulates HO-1, inducing its protein levels through both the increment of its promoter activity and the induction of its transcriptional activation.
|
26227317 |
2015 |