|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
There were no significant correlations between heme oxygenase-1 expression and other factors, such as size of the tumor, staging, age and sex.
|
10378773 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both TP- and HO-1-positive macrophages could be observed in the stroma in and around tumors in vertical growth melanomas.
|
11011118 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin (IL)-8, heme oxygenase-1 (HO-1), and vascular endothelial growth factor (VEGF) appear to be critically involved in immune responses associated with inflammation, infection and tumor growth.
|
12151344 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancer tissues revealed marked HO-1 immunoreactivity in tumor cells and in tumor associated immunocytes.
|
15897578 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased HMOX1 levels were detected only in CSIII tumors and may represent a molecular marker of this stage.
|
16906285 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that the long (GT)n repeat of HO-1 gene promoter was associated with a higher frequency of gastric adenocarcinoma, and the medium (GT)n repeat might possess protective effect against gastric adenocarcinoma with a lower frequency of lymphovascular invasion in tumors.
|
17520317 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accordingly, inhibition of HO-1 can be suggested as a potential therapeutic approach sensitizing tumors to radiation, chemotherapy, or photodynamic therapy.
|
17822372 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Likewise, inhibition of HO-1 activity by chronic administration of the HO-1 inhibitor tin protoporphyrin IX to mice reduces RhoAQL-induced tumor growth by 70%.
|
17881360 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CD4+ CD25+ FoxP3+ T-cell infiltration and heme oxygenase-1 expression correlate with tumor grade in human gliomas.
|
17216339 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To identify a common mechanism of action of HO-1 in cancer, we determined the global effect of HO-1 on the transcriptome of multiple tumor entities and identified a universal HO-1-associated gene expression signature.
|
20667089 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review discusses the implications of HO-1 properties for tumor proliferation and cell death, differentiation, angiogenesis and metastasis, and tumor-related inflammation.
|
20704546 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A great deal of data has demonstrated the roles of HO-1 in the formation, growth and metastasis of tumors.
|
20518085 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The stress-inducible cytoprotective enzyme heme oxygenase-1 (HO-1) may play a critical role in the growth and metastasis of tumors.
|
21808062 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HMOX1 mRNA expression was significantly higher in patients with higher grade and multiple tumors than in those with lower grade and single tumors (each p <0.05, respectively).
|
21168882 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, inhibition of HO-1 decreased tumor growth and MVD by suppressing angiogenic factors, particularly VEGF and HIF-1α.
|
21206978 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase-1 (HO-1) correlates with aggressive tumor behavior and chemotherapy resistance in pancreatic cancer (PC).
|
21495030 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression of the pro-survival protein heme oxygenase-1 (HO-1) and loss of the pro-apoptotic tumour suppressor PTEN are common events in prostate cancer (PCA).
|
21381033 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo studies confirmed that STAT3 nuclear delimitation was significantly decreased in PC3 tumors overexpressing HO-1 grown as xenografts in nude mice.
|
23226098 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase-1 (HO-1) potently influences tumor growth and metastasis.
|
22490514 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these results demonstrate that HO-1 is up-regulated in HNSCC and that nuclear localization of HO-1 is associated with malignant progression in this tumor type.
|
22580187 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nuclear HO-1 protein expression has been observed in various types of tumors including prostate cancer.
|
23591596 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, HMOX1 overexpressing tumors were smaller, less vascularized and oxygenated, and less metastatic.
|
23617628 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Since 1950, many studies have revealed the role of HMOX1 in reducing the impact of oxidative stress in many types of diseases, such as Alzheimer's disease, heart disease, and the development of tumors.
|
23939757 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
While the mechanisms of ZnPP's anticancer activity remain to be elucidated, it is generally believed that ZnPP suppresses tumor growth through inhibition of HO-1 activity.
|
23523860 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It has been suggested that inhibition of HO-1 expression is a potential therapeutic approach to sensitize tumors to chemotherapy and radiotherapy.
|
23707609 |
2013 |