|
Squamous cell carcinoma of the head and neck
|
0.300 |
Biomarker
|
disease |
CTD_human |
Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma.
|
22227861 |
2012 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that HOXA5 induces apoptosis in breast cancer cells.
|
17804711 |
2007 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have shown that loss of p53 correlated with loss of a developmentally regulated transcription factor, HOXA5, in primary breast cancer.
|
15545268 |
2005 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.
|
10879542 |
2000 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether p53-independent apoptotic pathways are involved in HOXA5-induced cell death, we engineered a p53-mutant breast cancer cell line, Hs578T, to inducibly express HOXA5.
|
14701762 |
2004 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, HOXA5 has been implicated as a tumour suppressor in breast cancer and shown to transactivate the p53 gene.
|
16861263 |
2007 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promoter hypermethylation of RASSF1A was observed in 39/54 (72%), HOXA5 in 36/54 (67%), BRCA1 in 15/54 (28%) and RARbeta2 in 8/54 (15%) breast cancers.
|
18538349 |
2008 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conversely, ectopic expression of HOXA5 in aggressive SUM149 or SUM159 breast cancer cells reversed the cellular and molecular alterations observed in the HOXA5-depleted cells.
|
27157614 |
2016 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies indicate that homeobox A5 (HOXA5) may serve as a tumour suppressor gene in breast cancers.
|
25875824 |
2015 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Homeobox A5 (HOXA5) is a master regulator of the morphogenesis and cell differentiation to be implicated as a tumor suppressor gene in breast cancer, but its role in lung cancer is still unknown.
|
19554572 |
2009 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genes affected by epigenetic changes in breast cancers include HoxA5, p21WAF, gelsolin, BRCA1, BRCA2, E-cadherin, steroid hormone receptors, and retinoic acid receptor II.
|
11501577 |
2001 |
|
Non-Small Cell Lung Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Nevertheless, the functional relevance of MPP8 and it's relation with HOXA5 in non-small cell lung cancer (NSCLC) is unknown.
|
29412790 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
These findings suggest that downregulation of the HOXA5 gene by aberrant promoter methylation occurs in the vast majority of NSCLCs and that it may play a role in the pathogenesis of NSCLC.
|
19554572 |
2009 |
|
Non-Small Cell Lung Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer.
|
28338293 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that expression levels of HOXA5 were significantly decreased in NSCLC tissues compared with adjacent normal tissues.
|
25549794 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Finally, we observed an inverse correlation between HOXA5 and miR-196a expression in NSCLC tissues.
|
22876840 |
2012 |
|
Non-Small Cell Lung Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
HOXA5 was identified as a tumor suppressor gene, which inhibited NSCLC cell metastasis by regulating cytoskeletal remodeling.
|
28423732 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In addition, HOXA5 expression was associated with better clinical outcome in non-small cell lung cancer patients with wild-type EGFR.
|
25875824 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our studies provide new insights into how HOXA5 and p53 cooperate to contribute to the suppression of lung cancer cell invasion and play good prognostic roles in NSCLC.
|
28529621 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In this study, two microRNAs, miR-1271 and miR-628, and their predicted target genes were identified differentially expressed in NSCLC by analyzing the miRNA and mRNA expression data from NSCLC tissues and their matching normal controls. miR-1271 and its target gene HOXA5 were selected for further investigation.
|
25686496 |
2015 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The majority of breast carcinomas show reduced or no expression of the transcription factor, HOXA5.
|
10875927 |
2000 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We conclude that loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.
|
10879542 |
2000 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In addition, we demonstrate that HOXA5 protein expression levels in breast carcinomas inversely co-relates with Epidermal Growth Factor Receptor (EGFR) expression.
|
17167183 |
2006 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
In addition, HOXA5 has been implicated as a tumour suppressor in breast cancer and shown to transactivate the p53 gene.
|
16861263 |
2007 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We have previously shown that HOXA5 induces apoptosis in breast cancer cells.
|
17804711 |
2007 |