|
leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed the expression pattern of the entire HOX 1 locus in a panel of leukemia-derived human cell lines representing various blood phenotypes.
|
1348930 |
1992 |
|
Childhood Leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed the expression pattern of the entire HOX 1 locus in a panel of leukemia-derived human cell lines representing various blood phenotypes.
|
1348930 |
1992 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The majority of breast carcinomas show reduced or no expression of the transcription factor, HOXA5.
|
10875927 |
2000 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.
|
10879542 |
2000 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We conclude that loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.
|
10879542 |
2000 |
|
Mammary Neoplasms
|
0.040 |
PosttranslationalModification
|
group |
BEFREE |
The HOXA5 promoter region was methylated in 16 out of 20 p53-negative breast tumour specimens.
|
10879542 |
2000 |
|
Idiopathic pulmonary hypertension
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A 2.5-fold increase in HOXA5 mRNA expression was demonstrated by quantitative reverse transcriptase-polymerase chain reaction in primary pulmonary hypertension lung specimens when compared to normal lung tissue.
|
11238043 |
2001 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A 2.5-fold increase in HOXA5 mRNA expression was demonstrated by quantitative reverse transcriptase-polymerase chain reaction in primary pulmonary hypertension lung specimens when compared to normal lung tissue.
|
11238043 |
2001 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genes affected by epigenetic changes in breast cancers include HoxA5, p21WAF, gelsolin, BRCA1, BRCA2, E-cadherin, steroid hormone receptors, and retinoic acid receptor II.
|
11501577 |
2001 |
|
Dwarfism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transgenic mice expressing the homeobox gene Hoxa5 under the control of Hoxb2 regulatory elements present a growth arrest during weeks two and three of postnatal development, resulting in proportionate dwarfism.
|
12163409 |
2002 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether p53-independent apoptotic pathways are involved in HOXA5-induced cell death, we engineered a p53-mutant breast cancer cell line, Hs578T, to inducibly express HOXA5.
|
14701762 |
2004 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
To determine whether p53-independent apoptotic pathways are involved in HOXA5-induced cell death, we engineered a p53-mutant breast cancer cell line, Hs578T, to inducibly express HOXA5.
|
14701762 |
2004 |
|
Mammary Neoplasms
|
0.040 |
AlteredExpression
|
group |
LHGDN |
HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8.
|
14701762 |
2004 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have shown that loss of p53 correlated with loss of a developmentally regulated transcription factor, HOXA5, in primary breast cancer.
|
15545268 |
2005 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We have shown that loss of p53 correlated with loss of a developmentally regulated transcription factor, HOXA5, in primary breast cancer.
|
15545268 |
2005 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The homeotic gene HOXA5 has been shown to play an important role in breast tumorigenesis.
|
15545268 |
2005 |
|
Werner Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gene expression changes that were common to all three cell types included up-regulation of GCK (glucokinase), CS (citrate synthase), HOX1 (heme oxygenase 1), CKMT2 (mitochondrial creatine kinase 2), MYC (v-myc myelocytomatosis viral oncogene homolog), and WRN (Werner syndrome helicase), and down-regulation of FBP1 (fructose-1, 6-bisphosphatase 1) and COL4A1 (collagen, type IV, alpha 1).
|
15561107 |
2005 |
|
Adenocarcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analysis revealed that HOXA5 and A10 proteins were localized in the cytoplasm of tumor cells in both adenocarcinoma and squamous cell carcinoma tissues.
|
16525661 |
2006 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
The downstream, evolutionary conserved island of HOXA5 showed hypomethylation in 18 tumors and complete methylation in others.
|
16575877 |
2006 |
|
Mammary Neoplasms
|
0.040 |
AlteredExpression
|
group |
LHGDN |
HOXA5 regulates hMLH1 expression in breast cancer cells.
|
16756717 |
2006 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, HOXA5 has been implicated as a tumour suppressor in breast cancer and shown to transactivate the p53 gene.
|
16861263 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, HOXA5 has been implicated as a tumour suppressor in breast cancer and shown to transactivate the p53 gene.
|
16861263 |
2007 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
In addition, HOXA5 has been implicated as a tumour suppressor in breast cancer and shown to transactivate the p53 gene.
|
16861263 |
2007 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
HOXA5 is targeted by cell-type-specific CpG island methylation in normal cells and during the development of acute myeloid leukaemia.
|
16861263 |
2007 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In addition, we demonstrate that HOXA5 protein expression levels in breast carcinomas inversely co-relates with Epidermal Growth Factor Receptor (EGFR) expression.
|
17167183 |
2006 |