|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Carcinogenesis
|
0.050 |
GeneticVariation
|
phenotype |
BEFREE |
In this study, we aimed to investigate the role of a novel transcript from the HOXA6-HOXA5 locus in colon cancer tumorigenesis.
|
31159758 |
2019 |
|
leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed the expression pattern of the entire HOX 1 locus in a panel of leukemia-derived human cell lines representing various blood phenotypes.
|
1348930 |
1992 |
|
Childhood Leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed the expression pattern of the entire HOX 1 locus in a panel of leukemia-derived human cell lines representing various blood phenotypes.
|
1348930 |
1992 |
|
Chronic Obstructive Airway Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms in HOX-1 and mEPH genes are associated with the development of COPD in Southwest China.
|
17203192 |
2007 |
|
Chronic Obstructive Airway Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphism in HOX-1 is associated with the severity of COPD in Southwest China.
|
17254481 |
2007 |
|
Diaphragmatic Hernia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
[The etiology of congenital diaphragmatic hernia and esophageal atresia: the Hox genes].
|
18351244 |
2007 |
|
Mouth Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma.
|
22227861 |
2012 |
|
Malignant neoplasm of mouth
|
0.300 |
Biomarker
|
group |
CTD_human |
Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma.
|
22227861 |
2012 |
|
Squamous cell carcinoma of the head and neck
|
0.300 |
Biomarker
|
disease |
CTD_human |
Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma.
|
22227861 |
2012 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that HOXA5 induces apoptosis in breast cancer cells.
|
17804711 |
2007 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether p53-independent apoptotic pathways are involved in HOXA5-induced cell death, we engineered a p53-mutant breast cancer cell line, Hs578T, to inducibly express HOXA5.
|
14701762 |
2004 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, HOXA5 has been implicated as a tumour suppressor in breast cancer and shown to transactivate the p53 gene.
|
16861263 |
2007 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promoter hypermethylation of RASSF1A was observed in 39/54 (72%), HOXA5 in 36/54 (67%), BRCA1 in 15/54 (28%) and RARbeta2 in 8/54 (15%) breast cancers.
|
18538349 |
2008 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies indicate that homeobox A5 (HOXA5) may serve as a tumour suppressor gene in breast cancers.
|
25875824 |
2015 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Homeobox A5 (HOXA5) is a master regulator of the morphogenesis and cell differentiation to be implicated as a tumor suppressor gene in breast cancer, but its role in lung cancer is still unknown.
|
19554572 |
2009 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genes affected by epigenetic changes in breast cancers include HoxA5, p21WAF, gelsolin, BRCA1, BRCA2, E-cadherin, steroid hormone receptors, and retinoic acid receptor II.
|
11501577 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOXA5 was identified as a tumor suppressor gene, which inhibited NSCLC cell metastasis by regulating cytoskeletal remodeling.
|
28423732 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Results confirm the presence of three significantly upregulated (>4-fold) homeobox genes (HOXA5, HOXD10 and HOXD11) in OSCC that may play a significant role in the pathogenesis of these tumors.
|
22227861 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A total of 147 genes were differentially methylated between tumor and matched tumor-adjacent gastric tissue, with HOXA5 and hedgehog signalling being the top-ranked gene and signalling pathway, respectively.
|
24674026 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies indicate that homeobox A5 (HOXA5) may serve as a tumour suppressor gene in breast cancers.
|
25875824 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No evidence for the alleged tumor-suppressor function of HOXA5 could be found.
|
20130239 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, the findings of this study demonstrate that HOXA5 acts as a tumor suppressor gene during the development and progresion of GC, possibly functioning by inhibiting the abnormal proliferation of cancer cells.
|
30015922 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A last, in vivo assay was performed to assess the tumor formation in nude mice in order to explore the roles of HOTAIR and HOXA5 in cell apoptosis and proliferation.
|
31168296 |
2019 |