|
Mouth Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma.
|
22227861 |
2012 |
|
Malignant neoplasm of mouth
|
0.300 |
Biomarker
|
group |
CTD_human |
Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma.
|
22227861 |
2012 |
|
Squamous cell carcinoma of the head and neck
|
0.300 |
Biomarker
|
disease |
CTD_human |
Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma.
|
22227861 |
2012 |
|
Diaphragmatic Hernia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
[The etiology of congenital diaphragmatic hernia and esophageal atresia: the Hox genes].
|
18351244 |
2007 |
|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Evidence from DMR and FL analyses indicated that dietary folate and alcohol intake may be associated with genomic regions with tumor suppressor activity such as the GSDMD and HOXA5 genes.
|
30940212 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A last, in vivo assay was performed to assess the tumor formation in nude mice in order to explore the roles of HOTAIR and HOXA5 in cell apoptosis and proliferation.
|
31168296 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conclusively, our results demonstrated that HOXA5 functions as a tumor suppressor in regulating tumor growth of GC under regulation of miR-196a, supporting its potential utility as a therapeutic target for GC.
|
30267809 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Western blot analysis demonstrated that stable overexpression of HOXA5 short RNA increased EGF receptor levels and facilitated its phosphorylation in both HCT116 cells and xenograft tumors.
|
31159758 |
2019 |
|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, the findings of this study demonstrate that HOXA5 acts as a tumor suppressor gene during the development and progresion of GC, possibly functioning by inhibiting the abnormal proliferation of cancer cells.
|
30015922 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After injecting mice models with si-GAS5, miR-196a-5p mimic or si-HOXA5, a larger tumor size was also observed within the rats (P < 0.05).
|
30201235 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOXA5 was identified as a tumor suppressor gene, which inhibited NSCLC cell metastasis by regulating cytoskeletal remodeling.
|
28423732 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Homeobox A5 (HOXA5) is a member of the homeobox (HOX) family and was upregulated in many types of tumors.
|
27960137 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer.
|
28338293 |
2017 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conversely, ectopic expression of HOXA5 in aggressive SUM149 or SUM159 breast cancer cells reversed the cellular and molecular alterations observed in the HOXA5-depleted cells.
|
27157614 |
2016 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies indicate that homeobox A5 (HOXA5) may serve as a tumour suppressor gene in breast cancers.
|
25875824 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies indicate that homeobox A5 (HOXA5) may serve as a tumour suppressor gene in breast cancers.
|
25875824 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A total of 147 genes were differentially methylated between tumor and matched tumor-adjacent gastric tissue, with HOXA5 and hedgehog signalling being the top-ranked gene and signalling pathway, respectively.
|
24674026 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Results confirm the presence of three significantly upregulated (>4-fold) homeobox genes (HOXA5, HOXD10 and HOXD11) in OSCC that may play a significant role in the pathogenesis of these tumors.
|
22227861 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No evidence for the alleged tumor-suppressor function of HOXA5 could be found.
|
20130239 |
2010 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Homeobox A5 (HOXA5) is a master regulator of the morphogenesis and cell differentiation to be implicated as a tumor suppressor gene in breast cancer, but its role in lung cancer is still unknown.
|
19554572 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Homeobox A5 (HOXA5) is a master regulator of the morphogenesis and cell differentiation to be implicated as a tumor suppressor gene in breast cancer, but its role in lung cancer is still unknown.
|
19554572 |
2009 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promoter hypermethylation of RASSF1A was observed in 39/54 (72%), HOXA5 in 36/54 (67%), BRCA1 in 15/54 (28%) and RARbeta2 in 8/54 (15%) breast cancers.
|
18538349 |
2008 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that HOXA5 induces apoptosis in breast cancer cells.
|
17804711 |
2007 |