|
Atherosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis.
|
22766337 |
2012 |
|
Atherosclerosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Haptoglobin (Hp) is an antioxidant protein and the major susceptibility gene for atherosclerosis in diabetic patients.
|
18082523 |
2007 |
|
Atherosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variation at the haptoglobin locus could have a direct effect on the degradation of elastin in atherosclerotic aorta, whereas variation at the cholesterol ester transfer protein locus could affect lipid metabolism and promote atherosclerosis.(ABSTRACT TRUNCATED AT 250 WORDS)
|
1967566 |
1990 |
|
Atherosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The haptoglobin 2-2 genotype is associated with atherosclerosis in type 2 diabetes mellitus.
|
27190085 |
2016 |
|
Atherosclerosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Zonulin reversibly modulate intestinal permeability (IP), the circulating zonulin levels were increased in diabetes, obesity, all of which are risk factors for atherosclerosis.
|
27353603 |
2016 |
|
Atherosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The haptoglobin 2-2 genotype is associated with lower haptoglobin concentrations and atherosclerosis in diabetes.
|
28830235 |
2017 |
|
Atherosclerosis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV.
|
16597321 |
2006 |
|
Atherosclerosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Serum haptoglobin levels are associated with non-transplant atherosclerosis.
|
14734126 |
2004 |
|
Atherosclerosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Haptoglobin (Hb) and adiponectin are antioxidant proteins and independent predictors of atherosclerotic vascular disease in diabetic patients.
|
23177015 |
2013 |
|
Atherosclerosis
|
0.600 |
Therapeutic
|
disease |
RGD |
Vasoprotective effect of vitamin E: rescue of ethanol-induced atherosclerosis and inflammatory stress in rat vascular wall.
|
23665315 |
2013 |
|
Atherosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that the Hp genotype would predict progression of coronary artery calcification (CAC), a marker of subclinical atherosclerosis.
|
22098782 |
2011 |
|
Atherosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Hp polymorphism is related to the prevalence and the outcome of various pathological conditions with altered iron metabolism such as hemochromatosis, infections, and atherosclerotic vascular disease.
|
12005209 |
2002 |
|
Atherosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings should foster research investigating the role of Hp polymorphism in human disease, and in vitamin C deficiency and atherosclerosis in particular.
|
17644791 |
2007 |
|
Atherosclerosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Beyond the conventional view of haptoglobin as a marker of hemolysis, several findings point towards an immunomodulatory effect of haptoglobin in B-cell mediated progression of atherosclerosis.
|
21507405 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications.
|
29799294 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The haptoglobin 1 allele correlates with white matter hyperintensities in middle-aged adults with type 1 diabetes.
|
25213335 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
When tested in serum samples collected during the pre-type 1 diabetes phase, elevated serum zonulin was detected in 70% of subjects and preceded by 3.5 +/- 0.9 years the onset of the disease in those patients who went on to develop type 1 diabetes.
|
16644703 |
2006 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Effect of vitamin E supplementation on HDL function by haptoglobin genotype in type 1 diabetes: results from the HapE randomized crossover pilot trial.
|
26002590 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Proinflammatory cytokines and lipopolysaccharides were increased in type 1 diabetes, and gut permeability (determined by zonulin levels) was significantly increased in type 1 diabetes and MODY2.
|
30224347 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Some new biomarkers have been suggested for diagnosis of CD including ischemia-modified albumin (IMA), soluble syndecan-1 (SSDC-1), regenerating gene Iα (REG-Iα), Neurotensin, and Zonulin, which can be useful for diagnosis and screening of CD in childhood T1D.
|
30214462 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
RGD |
The identification and validation of haptoglobin as a putative serum biomarker for autoimmune T1D in rats now affords us the opportunity to test the validity of this protein as a biomarker for human T1D, particularly in those situations where viral infection is believed to precede the onset of disease.
|
20975081 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Reported elevated IsoP and WBC count concentrations over time among Hp 2 allele carriers lead to the hypothesis that the antioxidative and anti-inflammatory capacity of the Hp 2 is inferior to that of the Hp 1 allele in type 1 diabetes.
|
26114833 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort.
|
27539884 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To evaluate endothelial function in adolescents with type 1 diabetes before the development of complications and to test for potential relationships between endothelial dysfunction and haptoglobin genotype.
|
17939622 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of the 1/1, 2/1 and 2/2 Hp genotypes was 28.5%, 46.7% and 24.8% in patients with type 1 diabetes and 20.9%, 38.8% and 40.3% in controls, respectively.
|
26122942 |
2015 |