HP, haptoglobin, 3240

N. diseases: 464; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3279786
Disease: ANHAPTOGLOBINEMIA
ANHAPTOGLOBINEMIA 		0.420 GeneticVariation disease CLINVAR
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 GeneticVariation disease BEFREE 4) Patients with late onset of psoriasis showed an increase in the blood group (Fy(a+bb-) and a decrease in the haptoglobin type 2-2. 71831 1977
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.010 Biomarker disease BEFREE Using this material it was demonstrated that the anomalous Hp inheritance in Down's syndrome was not due simply to an increase in maternal age when the children were born. 131662 1976
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome 		0.010 Biomarker disease BEFREE Using this material it was demonstrated that the anomalous Hp inheritance in Down's syndrome was not due simply to an increase in maternal age when the children were born. 131662 1976
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.360 GeneticVariation disease BEFREE Preliminary data suggest the possibility of linkage between the alpha-haptoglobin locus and third component of complement locus and depression spectrum disease, a depression which is familially defined by the presence of alcoholism in the first-degree family member. 401356 1979
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 GeneticVariation disease BEFREE Preliminary data suggest the possibility of linkage between the alpha-haptoglobin locus and third component of complement locus and depression spectrum disease, a depression which is familially defined by the presence of alcoholism in the first-degree family member. 401356 1979
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.060 GeneticVariation phenotype BEFREE Preliminary data suggest the possibility of linkage between the alpha-haptoglobin locus and third component of complement locus and depression spectrum disease, a depression which is familially defined by the presence of alcoholism in the first-degree family member. 401356 1979
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.010 GeneticVariation disease BEFREE Preliminary data suggest the possibility of linkage between the alpha-haptoglobin locus and third component of complement locus and depression spectrum disease, a depression which is familially defined by the presence of alcoholism in the first-degree family member. 401356 1979
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.360 Biomarker disease BEFREE The results show virtually no evidence of linkage between depression spectrum disease and C3, but suggestive evidence (lod score = 1.03) of linkage between depression spectrum disease and alpha-haptoglobin (both these linkages were previously suggested by significant results in sib-pair analyses). 431798 1979
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE The results show virtually no evidence of linkage between depression spectrum disease and C3, but suggestive evidence (lod score = 1.03) of linkage between depression spectrum disease and alpha-haptoglobin (both these linkages were previously suggested by significant results in sib-pair analyses). 431798 1979
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.060 Biomarker phenotype BEFREE The results show virtually no evidence of linkage between depression spectrum disease and C3, but suggestive evidence (lod score = 1.03) of linkage between depression spectrum disease and alpha-haptoglobin (both these linkages were previously suggested by significant results in sib-pair analyses). 431798 1979
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.360 Biomarker disease BEFREE Preliminary data indicate that depression spectrum disease may be linked to such genetic markers as C3 or alpha-haptoglobin. 760696 1979
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE Preliminary data indicate that depression spectrum disease may be linked to such genetic markers as C3 or alpha-haptoglobin. 760696 1979
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.060 Biomarker phenotype BEFREE Preliminary data indicate that depression spectrum disease may be linked to such genetic markers as C3 or alpha-haptoglobin. 760696 1979
CUI: C0341047
Disease: Hypertrophy of parotid gland
Hypertrophy of parotid gland 		0.010 AlteredExpression disease BEFREE Those found and which appear real include Rhesus D(u) with proteinuria; MN with splenomegaly and hepatomegaly; Ss with parotid enlargement; acid phosphatase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogense and haemoglobin J- Tongariki with presence of malarial parasites; phosphoglucomutase with proteinuria and parotid enlargement; haptoglobin with proteinuria and with splenomegaly and hepatomegaly. 822772 1976
CUI: C0267026
Disease: Actinic cheilitis
Actinic cheilitis 		0.010 GeneticVariation disease BEFREE Strong associations between alcoholic cirrhosis and alpha-1-antitrypsin PI*Z allele, haptoglobin HP*1 allele and acid phosphatase ACP AC phenotype were observed. 1512005 1992
CUI: C0751383
Disease: Juvenile Neuronal Ceroid Lipofuscinosis
Juvenile Neuronal Ceroid Lipofuscinosis 		0.020 GeneticVariation disease BEFREE The gene for Batten disease (CLN3) has been mapped to human chromosome 16 by demonstration of linkage to the haptoglobin locus, and its localization has been further refined using a panel of DNA markers. 1746562 1991
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.100 Biomarker group BEFREE As an acute-phase reactant HP may be functionally involved in the etiology of DM and DR, which are associated with immunologic and inflammatory processes, respectively. 1778611 1991
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.040 Biomarker disease BEFREE As an acute-phase reactant HP may be functionally involved in the etiology of DM and DR, which are associated with immunologic and inflammatory processes, respectively. 1778611 1991
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.570 Biomarker group BEFREE However, an association between haptoglobin 1 and increased blood pressure has been reported. 1789936 1991
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 GeneticVariation disease BEFREE An earlier report cited a contribution by the haptoglobin locus to genetic susceptibility for Type 2 diabetes. 1864490 1991
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE The role of haptoglobin in these families does not appear to be important, either with respect to association with diabetes or with respect to linkage with a secondary susceptibility locus. 1864490 1991
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.100 Biomarker group BEFREE The role of haptoglobin in these families does not appear to be important, either with respect to association with diabetes or with respect to linkage with a secondary susceptibility locus. 1864490 1991
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.600 GeneticVariation disease BEFREE Variation at the haptoglobin locus could have a direct effect on the degradation of elastin in atherosclerotic aorta, whereas variation at the cholesterol ester transfer protein locus could affect lipid metabolism and promote atherosclerosis.(ABSTRACT TRUNCATED AT 250 WORDS) 1967566 1990
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Variation at the haptoglobin locus could have a direct effect on the degradation of elastin in atherosclerotic aorta, whereas variation at the cholesterol ester transfer protein locus could affect lipid metabolism and promote atherosclerosis.(ABSTRACT TRUNCATED AT 250 WORDS) 1967566 1990