HP, haptoglobin, 3240

N. diseases: 464; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001430
Disease: Adenoma
Adenoma
0.010 Biomarker group BEFREE Two panels, one consisting of Hp and LRG1 and one of Hp, LRG1, RBP4 and FN1 were identified for high-risk adenomas and CRCs detection (sensitivity of 66 and 62%, respectively, at specificity of 95%). 31784980 2020
Malignant neoplasm of urinary bladder
0.010 Biomarker disease BEFREE FGF9 inhibition by a novel binding peptide has efficacy in gastric and bladder cancer per se and reverses resistance to cisplatin. 31805343 2020
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.010 Biomarker disease BEFREE FGF9 inhibition by a novel binding peptide has efficacy in gastric and bladder cancer per se and reverses resistance to cisplatin. 31805343 2020
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.010 Biomarker disease BEFREE FGF9 inhibition by a novel binding peptide has efficacy in gastric and bladder cancer per se and reverses resistance to cisplatin. 31805343 2020
CUI: C1740787
Disease: Cardiac autonomic neuropathy
Cardiac autonomic neuropathy
0.010 GeneticVariation disease BEFREE The haptoglobin 2-2 genotype is associated with cardiac autonomic neuropathy in type 1 diabetes: the RETRO HDLc study. 31529337 2020
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.010 Biomarker disease BEFREE Using a Cox model, we first estimated hazard ratios of amyotrophic lateral sclerosis and Parkinson disease in relation to leukocytes, immunoglobulin G, haptoglobin, and uric acid. 31604369 2019
CUI: C0002873
Disease: Anemia of chronic disease
Anemia of chronic disease
0.010 Biomarker phenotype BEFREE The concomitant presence of kidney failure, especially chronic kidney disease (CKD) and MM per se, leading to anaemia of chronic disease (ACD) in combination, provoked us to pose the question about their reciprocal dependence and relationship with specific biomarkers; namely, soluble transferrin receptor (sTfR), growth differentiation factor 15 (GDF15), hepcidin 25 and zonulin. 31683939 2019
CUI: C0004576
Disease: Babesiosis
Babesiosis
0.010 Biomarker disease BEFREE The laboratory abnormalities associated with babesiosis, such as low hematocrit, low hemoglobin, elevated lactate dehydrogenase, low haptoglobin, reticulocytosis, the presence of schistocytes on the peripheral blood smear and thrombocytopenia, can mimic other severe systemic disorders like thrombotic thrombocytopenic purpura (TTP). 31205845 2019
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms
0.010 GeneticVariation group BEFREE The purpose of this study was to investigate the type of haptoglobin genotype and its relationship with some nutritional and biochemical risk factors affecting the prevalence of esophageal cancer in patients with early stage esophageal cancer. 31653132 2019
CUI: C0017668
Disease: Focal glomerulosclerosis
Focal glomerulosclerosis
0.010 Biomarker disease BEFREE Zonulin concentrations did not differ in children with minimal change disease vs. focal segmental glomerulosclerosis, frequently relapsing vs. steroid-dependent vs. steroid-resistant clinical course, and were not influenced by the immunosuppressive treatment regimen. 31157195 2019
CUI: C0019189
Disease: Hepatitis, Chronic
Hepatitis, Chronic
0.010 Biomarker disease BEFREE Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma. 31485278 2019
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome
0.010 AlteredExpression group BEFREE <b>Objective:</b> We conducted this study to test the hypothesis that plasma zonulin levels are elevated in pediatric patients with nephrotic syndrome compared to healthy controls. 31157195 2019
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.010 Biomarker disease BEFREE PEG-modified chitosan NPs loaded with Zn(ii)-binding peptide (PEG/PZn-CS NPs) reduced Zn2+ concentrations and Aβ secretion in mouse neuroblastoma (N)2a cells stably over-expressing the APP Swedish mutation (N2aswe). 31588929 2019
CUI: C0029453
Disease: Osteopenia
Osteopenia
0.010 Biomarker disease BEFREE The succinyl-proteome experimental data indicated that apolipoprotein A-I, apolipoprotein A-II, hemoglobin subunit alpha, and haptoglobin were valuable for diagnosis and treatment in postmenopausal women with osteoporosis and osteopenia. 31663278 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.010 Biomarker disease BEFREE The succinyl-proteome experimental data indicated that apolipoprotein A-I, apolipoprotein A-II, hemoglobin subunit alpha, and haptoglobin were valuable for diagnosis and treatment in postmenopausal women with osteoporosis and osteopenia. 31663278 2019
CUI: C0032227
Disease: Pleural effusion disorder
Pleural effusion disorder
0.010 Biomarker group BEFREE The concentrations of Hp and sCD163 in the pleural effusion were measured by enzyme-linked immunosorbent assay (ELISA).The concentrations of Hp and sCD163 were significantly higher in the TPE group than in the MPE group (P < .05). 31626097 2019
CUI: C0032617
Disease: Polyuria
Polyuria
0.010 GeneticVariation phenotype BEFREE Consistently, the Hp 1-1 phenotype was more prevalent in subjects with polyuria compared to the reference group (28% vs 16%, P < .05). 31508879 2019
CUI: C0033581
Disease: prostatitis
prostatitis
0.010 Biomarker disease BEFREE Proteins involved in the acute phase response, including haptoglobin, inter-α-trypsin inhibitor, and α<sub>1</sub>-antitrypsin 1-1, were differentially represented in the urine of mice with prostate inflammation. 30995113 2019
Purpura, Thrombotic Thrombocytopenic
0.010 Biomarker disease BEFREE The laboratory abnormalities associated with babesiosis, such as low hematocrit, low hemoglobin, elevated lactate dehydrogenase, low haptoglobin, reticulocytosis, the presence of schistocytes on the peripheral blood smear and thrombocytopenia, can mimic other severe systemic disorders like thrombotic thrombocytopenic purpura (TTP). 31205845 2019
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.010 Biomarker disease BEFREE The concomitant presence of kidney failure, especially chronic kidney disease (CKD) and MM per se, leading to anaemia of chronic disease (ACD) in combination, provoked us to pose the question about their reciprocal dependence and relationship with specific biomarkers; namely, soluble transferrin receptor (sTfR), growth differentiation factor 15 (GDF15), hepcidin 25 and zonulin. 31683939 2019
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.010 Biomarker group BEFREE The expression levels of 7 proteins [Immunoglobulin heavy constant µ; proto-oncogene diffuse B-cell lymphoma (DBL2); 26S protease regulatory subunit 4 (P26s4); serum albumin; haptoglobin; and two unknown proteins with isoelectronic point (pI) of 6.41 and molecular weight of 35.4 kDa, and pI of 8.05 and molecular weight of 27.4 kDa, respectively] were downregulated in MM compared with healthy controls. 30651846 2019
CUI: C0080032
Disease: Pleural Effusion, Malignant
Pleural Effusion, Malignant
0.010 Biomarker disease BEFREE Clinical value of haptoglobin and soluble CD163 testing for the differential diagnosis of tuberculous and malignant pleural effusions. 31626097 2019
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.010 GeneticVariation phenotype BEFREE The interaction of Hp genotype with number of depressive symptoms on regional brain measures was assessed using regression analyses. 30809196 2019
CUI: C0151517
Disease: Complete atrioventricular block
Complete atrioventricular block
0.010 Biomarker disease BEFREE ROC curve analysis revealed that serum zonulin could be used to differentiate CHB from cirrhosis. 31485278 2019
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma
0.010 GeneticVariation disease BEFREE The purpose of this study was to investigate the type of haptoglobin genotype and its relationship with some nutritional and biochemical risk factors affecting the prevalence of esophageal cancer in patients with early stage esophageal cancer. 31653132 2019