HRAS, HRas proto-oncogene, GTPase, 3265

N. diseases: 698; N. variants: 29
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE Since both estradiol treatment and ras-oncogene overexpression enhance tumorigenicity of hormone-dependent breast-cancer cells, we studied the effects of estrogen and of the activated v-Ha-ras oncogene on NK susceptibility of MCF-7 human breast-cancer cells. 1993553 1991
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE The HRAS region of 11p is not the site of a primary alteration leading to breast cancer. 2406196 1990
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE Point mutation at codon 12 of the Ki-ras gene in a primary breast carcinoma and the MDA-MB-134 human mammary carcinoma cell line. 2188722 1990
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE Secondly, 53 members of 3 families having a high incidence of breast cancer were c-Ha-ras-1 genotyped. 2668204 1989
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE Lod scores for close linkage of each candidate sequence to breast cancer were -19.6 for HRAS, -12.3 for KRAS2, -1.0 for NRAS, -6.0 for MYC, -6.1 for MYB, -8.2 for ERBA2, -7.9 for INT2, and -5.1 for RAF1. 2564734 1989
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE Genetic alterations of c-myc, c-erbB-2, and c-Ha-ras protooncogenes and clinical associations in human breast carcinomas. 2573420 1989
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 AlteredExpression disease BEFREE No point mutations have been detected at the 12th codon of c-Ha-ras and c-Ki-ras in 40 and 65 breast cancer DNAs, respectively. 3293644 1988
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE The findings on Ha-ras and other informative loci are consistent with the possibility that a tumour suppressor gene involved in the early stages of breast cancer is located on the short arm of chromosome 11. 3066395 1988
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE The study was done on a total of 51 lung, colon and breast carcinoma tumors using a panel of oligonucleotides coding for the wild type and all possible mutations in codons 12 and 61 of c-K-ras gene. 3330777 1987
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 AlteredExpression disease BEFREE Enhanced Ha-ras expression was documented in 66% of breast and 100% of colon carcinomas as compared with their normal counterparts, with levels in breast carcinomas ranging from 10.1 to 50.4 pg ras p21/micrograms protein and those in colon carcinomas ranging from 18.4 to 51.7 pg ras p21/micrograms protein. 3298786 1987
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE Correlation with clinicopathological data showed, however, that the loss of one H-ras-1 allele in breast carcinoma DNAs is significantly linked to histological Grade III tumors, the lack of estrogen and/or progesterone receptors, and the subsequent occurrence of distal metastasis. 3524819 1986
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE The frequency of rare c-Ha-ras-1 alleles and hence genotypes composed of two rare alleles was increased in the breast cancer population (P less than .001). 3462411 1986
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 CausalMutation disease CGI