|
Parkinson Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Stepwise multivariate logistic regression analysis identified five genes as optimal predictors of PD: p19 S-phase kinase-associated protein 1A (odds ratio [OR] 0.73; 95% confidence interval [CI] 0.60-0.90), huntingtin interacting protein-2 (OR 1.32; CI 1.08-1.61), aldehyde dehydrogenase family 1 subfamily A1 (OR 0.86; 95% CI 0.75-0.99), 19 S proteasomal protein PSMC4 (OR 0.73; 95% CI 0.60-0.89) and heat shock 70-kDa protein 8 (OR 1.39; 95% CI 1.14-1.70).
|
22651796 |
2012 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Tumors with weak (+) HSC70 protein staining were more frequent in the carriers of the polymorphic 1541-1542delGT allele than in the homozygotes of the major allele (20% vs. 6%, P=0.05 by Fisher's exact test).
|
14991745 |
2004 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In both cases, mutation was coincident with allelic imbalance, suggesting that HSC70 is a target of somatic mutation and deletion in a fraction of breast carcinomas.
|
10485459 |
1999 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models.
|
23065205 |
2012 |
|
Malignant neoplasm of breast
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models.
|
23065205 |
2012 |
|
Dystonia
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
LAP1 interacts with torsinA, the protein mutated in DYT1-dystonia.
|
25425325 |
2014 |
|
Dystonia Disorders
|
0.040 |
GeneticVariation
|
group |
BEFREE |
LAP1 interacts with torsinA, the protein mutated in DYT1-dystonia.
|
25425325 |
2014 |
|
Muscular Dystrophy
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Conditional deletion of LAP1 from striated muscle causes muscular dystrophy; this pathology is worsened in the absence of emerin.
|
24055652 |
2013 |
|
Rheumatoid Arthritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Quantitative precipitation assay from total cellular proteins and from lysosomal extracts demonstrated that RA-associated HLA-DRB1 alleles bound Hsp73 better than did HLA-DRB1 alleles that were not associated with RA.
|
11953969 |
2002 |
|
Atrial Fibrillation
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
Association of Met439Thr substitution in heat shock protein 70 gene with postoperative atrial fibrillation and serum HSP70 protein levels.
|
17934269 |
2008 |
|
Schizophrenia
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia.
|
18299791 |
2008 |
|
Carcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To examine whether intragenic, somatic mutations of HSPA8 occur in lung carcinomas, we sequenced its exons 2-8, with adjacent intronic sequences, in a series of DNA samples from non-small-cell lung cancers (NSCLC).
|
14991745 |
2004 |
|
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population.
|
20300519 |
2010 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to investigate whether certain genetic variants of HSPA8 gene are associated with CHD in Han Chinese people.
|
20300519 |
2010 |
|
Liver Cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Elevated expression of glucose-regulated protein 78 (GRP78) and heat shock cognate protein (Hsc70) were detected in 100% of HCC and adjacent non-tumorous cirrhotic livers, suggesting that unresolved ER-stress is associated with HCC risk in liver cirrhosis.
|
28402954 |
2017 |
|
Malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk.
|
14991745 |
2004 |
|
Psychotic episodes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that FEP patients presented a polymorphism differentiation related to the HSPA8 gene (rs1136141), and a higher frequency of T carriers compared to healthy controls was observed.
|
24548631 |
2014 |
|
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk.
|
14991745 |
2004 |
|
Primary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk.
|
14991745 |
2004 |
|
Coronary Artery Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population.
|
20300519 |
2010 |
|
Malignant neoplasm of stomach
|
0.310 |
Biomarker
|
disease |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Malignant neoplasm of stomach
|
0.310 |
Biomarker
|
disease |
BEFREE |
GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway.
|
31382983 |
2019 |
|
SPINOCEREBELLAR ATAXIA 17
|
0.310 |
Biomarker
|
disease |
BEFREE |
Previously proteomics study using a cellular model of SCA17 has revealed reduced expression of heat shock 70 kDa protein 5 (HSPA5) and heat shock 70 kDa protein 8 (HSPA8), suggesting that impaired protein folding may contribute to the cell dysfunction of SCA17 (Lee et al., 2009).
|
22530004 |
2012 |
|
SPINOCEREBELLAR ATAXIA 17
|
0.310 |
Biomarker
|
disease |
CTD_human |
Downregulation of proteins involved in the endoplasmic reticulum stress response and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17.
|
24413982 |
2014 |