|
Acute Coronary Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
"Proteomic changes related to ""bewildered"" circulating platelets in the acute coronary syndrome."
|
21751358 |
2011 |
|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin.
|
14966137 |
2004 |
|
Adenocarcinoma
|
0.300 |
Biomarker
|
group |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tissue array analysis revealed that the expression levels of NCL and Hsc70 were intimately correlated in human lung adenocarcinomas.
|
22743058 |
2012 |
|
Adenocarcinoma, Basal Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Adenocarcinoma, Oxyphilic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Adenocarcinoma, Tubular
|
0.300 |
Biomarker
|
disease |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Adult Extraskeletal Myxoid Chondrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma.
|
28383167 |
2017 |
|
Adult Glioblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
As a result, nestin shRNA-transfected glioblastoma cells exhibited a decrease in the level of phosphorylation of heat shock cognate 71 kDa protein (HSC71; gene HSPA8).
|
25527454 |
2015 |
|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
A significant downregulation of HSPA8 and HSPA9 was observed in AD across the three brain regions compared to the controls, suggesting their participation in AD pathogenesis.
|
23948933 |
2014 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we report the interaction between the human Hsp70 isoform heat shock cognate 71-kDa protein (Hsc70 or HSPA8) and peptides derived from the microtubule-associated protein Tau, which is linked to Alzheimer's disease.
|
29764935 |
2018 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
The expression levels of the chaperone-mediated autophagy proteins LAMP2A and hsc70 were significantly reduced in the substantia nigra pars compacta and amygdala of PD brains compared with age-matched AD and control brain samples.
|
20697033 |
2010 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the effects of a small-molecule HSC70 inhibitor, VER-155008, on axonal morphology and memory function in a mouse model of AD (5XFAD mice).
|
29441022 |
2018 |
|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Our study indicated that reducing the HSC70 level is a new possible therapeutic target of axonal regeneration in AD.
|
30076345 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using a Drosophila model of ALS, we show that TDP-43 overexpression (OE) in motor neurons results in decreased expression of the Hsc70-4 chaperone at the neuromuscular junction (NMJ).
|
28978466 |
2017 |
|
Atrial Fibrillation
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
Association of Met439Thr substitution in heat shock protein 70 gene with postoperative atrial fibrillation and serum HSP70 protein levels.
|
17934269 |
2008 |
|
Atrial Fibrillation
|
0.020 |
Biomarker
|
disease |
BEFREE |
We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.
|
30678657 |
2019 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Moreover, the mapped network in B lymphocytes comprised two additional hub proteins involved in both inflammation and autoimmunity: HSPA8 (Heat Shock Protein Family A Member 8 also known as HSC70) and HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1).
|
31824497 |
2019 |
|
Brain Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Irreversible aggregation of protein synthesis machinery after focal brain ischemia.
|
16805800 |
2006 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Somatic mutations of 11q23.3-linked constitutive heat shock protein 70 gene (HSPA8 alias HSC70) are detected by others in breast carcinomas.
|
14991745 |
2004 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Hsc70 appears active in human breast cancer cells and hypersecreted by direct cath D inhibition.
|
19802014 |
2010 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer.
|
29510992 |
2018 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In both cases, mutation was coincident with allelic imbalance, suggesting that HSC70 is a target of somatic mutation and deletion in a fraction of breast carcinomas.
|
10485459 |
1999 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the impact of Hsp70 protein expression, and its close family member, Hsc70, on breast cancer cell viability and on the activity of the Hsp90/Hsp70 chaperone complex, a complex whose activity is important for the survival of cancer cells and tumours.
|
17487411 |
2007 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models.
|
23065205 |
2012 |