HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques. 12851635 2003
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect. 10898915 2000
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Ongoing research has identified a region of the HTR2A promoter that has been associated with a number of medical outcomes in adults and infants, including bipolar disorder, schizophrenia, chronic fatigue syndrome, borderline personality disorder, suicidality, and neurobehavioral outcomes. 25043477 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE These results indicate that, in our sample, the 5-HT2A receptor polymorphism studied is unlikely to play a major role in the genetic susceptibility to BPAD.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:136-140, 2000. 10893484 2000
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE We previously reported linkage evidence for a bipolar affective disorder susceptibility locus on chromosome 13q, which harbours HTR2A, thus making the gene both a positional and functional candidate. 19584773 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder. 17221840 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Although further studies are necessary, these results in a Korean population suggest that -1438A/G polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder. 11702051 2001
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE The association detected in this study suggests that the 5-HT(2A) receptor gene may play a role in the genetic susceptibility to bipolar disorder, through a specific subgroup of bipolar type I patients with lower risk of suicidal behavior. 11983190 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE These preliminary results may indicate that in our sample the 5-HT2 receptor polymorphism studied is unlikely to play a role in the genetic susceptibility to BPAD. 9194200 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Cytosine methylation of HTR2A at T102C polymorphic site in DNA derived from the saliva can potentially be used as a diagnostic, prognostic, and/or therapeutic biomarker in SCZ and BD. 21598376 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE In secondary analyses, HTR2A (rs643627, p = 0.002) and CHL1 (rs4003413, p = 0.002) were found associated with risk for BD, HOMER1 (rs6872497, p = 0.002) with lifetime history of suicide attempt in patients, and RORA with early onset and presence of psychotic features in BD. 30178121 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD. 23404241 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE The 5-HT2A receptor gene was systematically screened for genetic variants by single strand conformation polymorphism (SSCP) methods in subjects with bipolar affective disorder. 9086465 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE No significant transmission disequilibrium between the alleles of 5-HT2A and BP was found. 12622403 2002
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE The meta-analysis supports a contribution of the HTR2A gene to the susceptibility to substance use disorders, particularly alcohol dependence. 24178752 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE The results suggest that the human HTR2 MspI polymorphism might not be associated with a risk factor for developing alcohol dependence or susceptibility to schizophrenia. 10754425 2000
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE There was no association between the 5-HT2A receptor polymorphism (T102C), the intron 7 TPH (A218C) polymorphisms and alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy in our subsets of German patients. 11444684 2001
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE The aim of the present study was to test for possible associations between the A-1438G polymorphism in the serotonin receptor gene (HTR2A) with tobacco smoking combined or not with alcohol dependence. 19111403 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE There was no evidence that two polymorphisms of the 5-HT2A receptor gene and one of the 5-HT2C receptor gene were related to LR or alcoholism in this sample. 10088053 1999
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE The results suggest a potential role of the T102C HTR2A polymorphism in development of alcohol dependence. 22661198 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE T102C polymorphism of the serotonin receptor 2A gene (5-HT2A) has been shown to be associated with certain diseases such as non-fatal acute myocardial infarction, essential hypertension, and alcoholism. 17713649 2007
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE However, the potential association between the rs6313" genes_norm="3356">T102C polymorphism (rs6313) in the type 2A serotonin receptor (HTR2A) gene and treatment outcomes in alcohol dependence has not been investigated. 23321485 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.700 GeneticVariation disease BEFREE Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder. 17221840 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.700 GeneticVariation disease BEFREE We detected nominal significant association with schizophrenia for several haplotype tag SNPs (htSNPs) at HTR2A, although the significance was lost after multiple test corrections. 17125970 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.700 GeneticVariation disease BEFREE We looked for an association between schizophrenia and this variant of the 5-HT2a-receptor gene in a large multicentre study. 8622505 1996