|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms of the apolipoprotein B gene with coronary heart disease in Han Chinese.
|
8546754 |
1995 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This suggests that variation at the ApoB locus may be involved independently in the determination of serum lipid levels and in the development of ischaemic heart disease.
|
2452042 |
1988 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of DNA polymorphism at the apolipoprotein B gene locus with coronary heart disease and serum very low density lipoprotein levels.
|
1967524 |
1990 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interaction between SREBP-1a and APOB polymorphisms influences total and low-density lipoprotein cholesterol levels in patients with coronary artery disease.
|
12752570 |
2003 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) and the Apolipoprotein B/A1 Ratio Independently Associate With Surgery for Aortic Stenosis Only in Patients With Concomitant Coronary Artery Disease.
|
29246959 |
2017 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three polymorphic sites of the apolipoprotein B gene - the insertion/deletion signal peptide, XbaI and EcoRI sites - were examined in a sample of 107 healthy men and in 46 men with evidence of coronary heart disease selected from a large population survey of South Asians aged 40-69 in London, U.K.
|
1789809 |
1991 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The plasma level of apolipoprotein B (apoB) is among the strongest risk factors for coronary artery disease.
|
24201112 |
2013 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Evolution of the apolipoprotein B gene and coronary artery disease: a study in low and high risk Asians.
|
10738520 |
1999 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Association between apolipoprotein B EcoRI polymorphisms and coronary heart disease : A meta-analysis.
|
27637205 |
2016 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
An elevated plasma level of apolipoprotein B (apoB), the major protein of low density lipoproteins, is a risk factor for coronary artery disease.
|
8349099 |
1993 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine whether the APOE association may be a risk factor for coronary disease as well, we examined two APOB gene restriction sites that have previously been found to be associated with coronary artery disease, especially myocardial infarctions.
|
8530010 |
1995 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the apolipoprotein B-100 gene (APOB) can result in a phenotype that is clinically indistinguishable from familial hypercholesterolemia, and mutations in this gene have also been shown to be associated with coronary heart disease.
|
15321838 |
2004 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Since the apoB plasma level was not only associated with the apoB SP Ins/Del gene variation but also to the extent of coronary artery disease (P <0.0001), individuals with an InsIns genotype and without CAD had the lowest and subjects with a DelDel genotype and triple vessel disease the highest apoB plasma levels (P <0.0001).
|
9863550 |
1998 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Studies comparing patients and controls, however, did not confirm previous studies suggesting that the multi-allelic variation at the 3'VNTR region of the apolipoprotein B gene was associated with coronary artery disease.
|
1418918 |
1992 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Single effects of apolipoprotein B, (a), and E polymorphisms and interaction between plasminogen activator inhibitor-1 and apolipoprotein(a) genotypes and the risk of coronary artery disease in Czech male caucasians.
|
10720441 |
2000 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Postprandial triglycerides, TG-rich lipoprotein triglycerides, retinyl palmitate and apolipoprotein B48 to B100 ratio were measured before (following a 12-hour fasting period) and after a fat-tolerance test meal in a middle-aged, biracial subcohort without CVD (coronary heart disease (CHD) or stroke) from the community-based Atherosclerosis Risk in Communities (ARIC) Study in 1990-1993.
|
28191321 |
2017 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein B gene 3'VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese.
|
17032131 |
2006 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The XbaI, EcoRI and the signal peptide insertion/deletion (I/D) polymorphic sites of APOB gene, the CfoI polymorphic site of apolipoprotein E gene (APOE), and the insertion/deletion polymorphism of angiotensin I-converting enzyme (ACE) gene were studied using polymerase chain reaction (PCR) in 55 postmenopausal women with coronary artery disease (CAD) and in 119 control women of equivalent age.
|
9298741 |
1997 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Immunologically defined alleles of the pig apolipoprotein B (ApoB) locus (apoB) are correlated with different blood cholesterol levels and predisposition towards premature coronary heart disease.
|
2905687 |
1988 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between the Xba I polymorphism of APOB gene and plasma lipid level in Mexican patients with coronary artery disease.
|
22507620 |
2012 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II.
|
27112212 |
2016 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Together these results suggest that inherited variations of the apolipoprotein-B gene, probably in the form of charged aminoacid substitutions, influence circulating cholesterol concentration, and that these and other functional variants of the apolipoprotein-B gene affect susceptibility to coronary heart disease and obesity.
|
2904569 |
1989 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein B allotypes MB19(1) and MB19(2) in subjects with coronary artery disease and hypercholesterolemia.
|
2434069 |
1987 |
|
Coronary Arteriosclerosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Apolipoprotein B levels were strongly associated with coronary artery disease in four of five prospective studies but were more predictive of coronary artery disease than were total cholesterol levels in only two of the four studies.
|
8185133 |
1994 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The X-X-/E+E+ genotype of the XbaI/EcoRI polymorphisms of the apolipoprotein B gene as a marker of coronary artery disease in a Brazilian sample.
|
12640502 |
2003 |