|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein B gene polymorphisms, lipoproteins and coronary atherosclerosis: a study of young myocardial infarction survivors and healthy population-based individuals.
|
1352974 |
1992 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Lipid parameters and apolipoprotein B RFLP studies: comparison of normal and coronary heart disease groups as defined by angiography.
|
1362695 |
1992 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Studies comparing patients and controls, however, did not confirm previous studies suggesting that the multi-allelic variation at the 3'VNTR region of the apolipoprotein B gene was associated with coronary artery disease.
|
1418918 |
1992 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have investigated the frequency of Hind III DNA polymorphism of the human apolipoprotein B gene in a Canadian Caucasian population with coronary artery disease, as documented by angiography, and a healthy control population.
|
1477972 |
1992 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have examined DNA polymorphisms associated with the apolipoprotein B gene in 95 Sri Lankan males with ischaemic heart disease and 95 matched controls.
|
1674237 |
1991 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between the apolipoprotein B gene 3' hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease.
|
1732399 |
1992 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three polymorphic sites of the apolipoprotein B gene - the insertion/deletion signal peptide, XbaI and EcoRI sites - were examined in a sample of 107 healthy men and in 46 men with evidence of coronary heart disease selected from a large population survey of South Asians aged 40-69 in London, U.K.
|
1789809 |
1991 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of DNA polymorphism at the apolipoprotein B gene locus with coronary heart disease and serum very low density lipoprotein levels.
|
1967524 |
1990 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Hypervariability in a minisatellite 3' of the apolipoprotein B gene in patients with coronary heart disease compared with normal controls.
|
2351870 |
1990 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein B allotypes MB19(1) and MB19(2) in subjects with coronary artery disease and hypercholesterolemia.
|
2434069 |
1987 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This suggests that variation at the ApoB locus may be involved independently in the determination of serum lipid levels and in the development of ischaemic heart disease.
|
2452042 |
1988 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Together these results suggest that inherited variations of the apolipoprotein-B gene, probably in the form of charged aminoacid substitutions, influence circulating cholesterol concentration, and that these and other functional variants of the apolipoprotein-B gene affect susceptibility to coronary heart disease and obesity.
|
2904569 |
1989 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Immunologically defined alleles of the pig apolipoprotein B (ApoB) locus (apoB) are correlated with different blood cholesterol levels and predisposition towards premature coronary heart disease.
|
2905687 |
1988 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein(a) (Lp(a)), a low-density lipoprotein-like particle distinguished by the presence of the glycoprotein apolipoprotein(a) (apo(a)), which is bound to apolipoprotein B-100 (apoB-100) by disulfide bridges.
|
2976021 |
1988 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Levels of apolipoprotein B, the protein component of low-density lipoproteins, correlate with the risk of coronary heart disease.
|
3024002 |
1986 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein B and apolipoprotein AI as predictors of coronary artery disease.
|
3141025 |
1988 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Restriction fragment length polymorphisms of apolipoprotein B gene in Chinese population with coronary heart disease.
|
7533671 |
1995 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of genotypes at the apolipoprotein AI-CIII-AIV, apolipoprotein B and lipoprotein lipase gene loci with coronary atherosclerosis and high density lipoprotein subclasses.
|
7834891 |
1994 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of apolipoprotein B gene in relation to coronary heart disease in Chinese Han nationality.
|
7910546 |
1994 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Low density lipoprotein cholesterol/apolipoprotein B-100 ratio: interaction of family history of premature atherosclerotic coronary artery disease with race and gender in 7 to 11 year olds.
|
7936858 |
1994 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The presence of mutant apo B-100 in low-density lipoproteins (LDL) markedly reduces their affinity for the LDL receptor, leading to hypercholesterolaemia and increased proneness to coronary artery disease.
|
8141833 |
1993 |
|
Coronary Arteriosclerosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Apolipoprotein B levels were strongly associated with coronary artery disease in four of five prospective studies but were more predictive of coronary artery disease than were total cholesterol levels in only two of the four studies.
|
8185133 |
1994 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By direct comparison of the Lp(a) and apoB plasma concentrations in 28 affected and 31 unaffected members of seven families carrying the FH trait and without history of coronary artery disease, we reached the conclusion that LDL receptor activity is not a major determinant of the Lp(a) plasma levels in these subjects.
|
8187228 |
1994 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
An elevated plasma level of apolipoprotein B (apoB), the major protein of low density lipoproteins, is a risk factor for coronary artery disease.
|
8349099 |
1993 |