Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms of the apolipoprotein B gene with coronary heart disease in Han Chinese.
|
8546754 |
1995 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This suggests that variation at the ApoB locus may be involved independently in the determination of serum lipid levels and in the development of ischaemic heart disease.
|
2452042 |
1988 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of DNA polymorphism at the apolipoprotein B gene locus with coronary heart disease and serum very low density lipoprotein levels.
|
1967524 |
1990 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interaction between SREBP-1a and APOB polymorphisms influences total and low-density lipoprotein cholesterol levels in patients with coronary artery disease.
|
12752570 |
2003 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) and the Apolipoprotein B/A1 Ratio Independently Associate With Surgery for Aortic Stenosis Only in Patients With Concomitant Coronary Artery Disease.
|
29246959 |
2017 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three polymorphic sites of the apolipoprotein B gene - the insertion/deletion signal peptide, XbaI and EcoRI sites - were examined in a sample of 107 healthy men and in 46 men with evidence of coronary heart disease selected from a large population survey of South Asians aged 40-69 in London, U.K.
|
1789809 |
1991 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The plasma level of apolipoprotein B (apoB) is among the strongest risk factors for coronary artery disease.
|
24201112 |
2013 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Evolution of the apolipoprotein B gene and coronary artery disease: a study in low and high risk Asians.
|
10738520 |
1999 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine whether the APOE association may be a risk factor for coronary disease as well, we examined two APOB gene restriction sites that have previously been found to be associated with coronary artery disease, especially myocardial infarctions.
|
8530010 |
1995 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the apolipoprotein B-100 gene (APOB) can result in a phenotype that is clinically indistinguishable from familial hypercholesterolemia, and mutations in this gene have also been shown to be associated with coronary heart disease.
|
15321838 |
2004 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Since the apoB plasma level was not only associated with the apoB SP Ins/Del gene variation but also to the extent of coronary artery disease (P <0.0001), individuals with an InsIns genotype and without CAD had the lowest and subjects with a DelDel genotype and triple vessel disease the highest apoB plasma levels (P <0.0001).
|
9863550 |
1998 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Studies comparing patients and controls, however, did not confirm previous studies suggesting that the multi-allelic variation at the 3'VNTR region of the apolipoprotein B gene was associated with coronary artery disease.
|
1418918 |
1992 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Single effects of apolipoprotein B, (a), and E polymorphisms and interaction between plasminogen activator inhibitor-1 and apolipoprotein(a) genotypes and the risk of coronary artery disease in Czech male caucasians.
|
10720441 |
2000 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein B gene 3'VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese.
|
17032131 |
2006 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The XbaI, EcoRI and the signal peptide insertion/deletion (I/D) polymorphic sites of APOB gene, the CfoI polymorphic site of apolipoprotein E gene (APOE), and the insertion/deletion polymorphism of angiotensin I-converting enzyme (ACE) gene were studied using polymerase chain reaction (PCR) in 55 postmenopausal women with coronary artery disease (CAD) and in 119 control women of equivalent age.
|
9298741 |
1997 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Immunologically defined alleles of the pig apolipoprotein B (ApoB) locus (apoB) are correlated with different blood cholesterol levels and predisposition towards premature coronary heart disease.
|
2905687 |
1988 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between the Xba I polymorphism of APOB gene and plasma lipid level in Mexican patients with coronary artery disease.
|
22507620 |
2012 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II.
|
27112212 |
2016 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Together these results suggest that inherited variations of the apolipoprotein-B gene, probably in the form of charged aminoacid substitutions, influence circulating cholesterol concentration, and that these and other functional variants of the apolipoprotein-B gene affect susceptibility to coronary heart disease and obesity.
|
2904569 |
1989 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The X-X-/E+E+ genotype of the XbaI/EcoRI polymorphisms of the apolipoprotein B gene as a marker of coronary artery disease in a Brazilian sample.
|
12640502 |
2003 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Hypervariability in a minisatellite 3' of the apolipoprotein B gene in patients with coronary heart disease compared with normal controls.
|
2351870 |
1990 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between the apolipoprotein B gene 3' hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease.
|
1732399 |
1992 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the apolipoprotein B 3' variable number of tandem repeats region associated with coronary artery disease in Taiwanese.
|
9585673 |
1998 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with coronary heart disease (CHD).
|
26537298 |
2015 |
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations of the apolipoprotein B gene in Turkish patients with coronary artery disease.
|
16316917 |
2006 |