|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Blood cultures were stimulated with different viruses (respiratory syncytial virus (RSV), newcastle disease virus (NDV)) and analysed for IFN-alpha2 protein release and gene transcription.
|
16499644 |
2006 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The L protein specifically inhibits the transcription of the IFN-alpha4 and IFN-beta genes, which are known to be activated early in response to viral infection.
|
11483724 |
2001 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral infections, might be complicated in the progression of HAM/TSP.
|
29990995 |
2018 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Cloning of woodchuck IFNA genes will allow testing diverse forms of IFN-alpha delivery as well as different combination therapies in woodchuck hepatitis virus infection, thus providing useful information for the design of new strategies for the treatment of patients with chronic hepatitis B.
|
12226832 |
2002 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A detailed immunological investigation of these patients revealed impaired responses to type I IFN, IL-10, IL-12 and IL-23, which are associated with increased susceptibility to mycobacterial and/or viral infections.
|
29725107 |
2018 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Because suppression of the IFN response to viral infection was associated with increased viral production, we assessed HRV-16 RNA concentrations.
|
20224072 |
2011 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Human choriocarcinoma cells (Jar) stably transfected with 1.8 kilobases of promoter from a bovine IFN tau gene ahead of a human GH (hGH) reporter gene constitutively synthesize hGH, but expression is not increased further by exposure to Newcastle disease virus.
|
8052267 |
1994 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our data suggest a role of the CBLB rs12487066 variant in the interactions of a genetic risk factor and IFN function during viral infections in MS.
|
25261476 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs.
|
30995506 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFNL polymorphisms influence regulatory pathways of cellular response to IFN and affect body iron balance in chronic hepatitis C virus infection.
|
27125837 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as the first line of defense against virus infection and regulate the development of both innate and adaptive immune responses.
|
28289095 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, viral RNA-induced type I IFN regulates the antigen-processing machinery early during viral infection and prior to IFN-gamma response.
|
18184038 |
2007 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
During its migration in the nervous system (NS), RABV triggers an innate immune response, including a type I IFN response well known to limit viral infections.
|
21805057 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, this research on CoBoIFN-ω not only extends and improves consensus IFN research, but also reveals that CoBoIFN-ω has the potential to be used in the therapy of bovine viral diseases.
|
30576951 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Innate immunity to viral infection involves induction of the type I IFN response; however, dysfunctional regulation of this pathway leads to inappropriate inflammation.
|
25401470 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Toll-like receptor 3 (TLR3) plays a critical role in initiating type I IFN-mediated innate immunity against viral infections.
|
23035017 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The actions of IFN-stimulated genes (ISGs) impart control of virus infection, but the specific ISGs and regulatory pathways that restrict West Nile virus (WNV) are not defined.
|
22065572 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Some controversy exists around IL-27 and IFN-α, cytokines possibly released during bacterial or viral infections.
|
26324343 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters.
|
31784575 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-α 2b therapy maybe useful in controlling recalcitrant viral infections in these patients.
|
24743019 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review we focus on the role of IFN-λ at barrier surfaces, focusing on the respiratory and GI tracts, the BBB, and the placenta, and on how these IFNs act to suppress viral infections.
|
30219309 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection.
|
31379819 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferons (IFNs) are secreted glycoproteins that are produced by cells in response to virus infection and other stimuli and induce an antiviral state in cells bearing IFN receptors.
|
29551142 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
SCARB2 or PSGL-1 receptor binding is the first step in the development of viral infections, and viral factors (e.g., 5' UTR, VP1, 3C, 3D, 3' UTR), host factors and environments (e.g., ITAFs, type I IFN) are also involved in viral infections.
|
24602216 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses.
|
28963109 |
2018 |