|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs.
|
30995506 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFNL polymorphisms influence regulatory pathways of cellular response to IFN and affect body iron balance in chronic hepatitis C virus infection.
|
27125837 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This discovery not only reveals a regulatory pathway for controlling IFN-α1 gene expression during the host innate immune response against virus infection but also suggests a reason for the large number of overlapping complementary transcripts with previously unknown function.
|
23224365 |
2013 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Blood cultures were stimulated with different viruses (respiratory syncytial virus (RSV), newcastle disease virus (NDV)) and analysed for IFN-alpha2 protein release and gene transcription.
|
16499644 |
2006 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as the first line of defense against virus infection and regulate the development of both innate and adaptive immune responses.
|
28289095 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, viral RNA-induced type I IFN regulates the antigen-processing machinery early during viral infection and prior to IFN-gamma response.
|
18184038 |
2007 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
During its migration in the nervous system (NS), RABV triggers an innate immune response, including a type I IFN response well known to limit viral infections.
|
21805057 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, this research on CoBoIFN-ω not only extends and improves consensus IFN research, but also reveals that CoBoIFN-ω has the potential to be used in the therapy of bovine viral diseases.
|
30576951 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Innate immunity to viral infection involves induction of the type I IFN response; however, dysfunctional regulation of this pathway leads to inappropriate inflammation.
|
25401470 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Toll-like receptor 3 (TLR3) plays a critical role in initiating type I IFN-mediated innate immunity against viral infections.
|
23035017 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The actions of IFN-stimulated genes (ISGs) impart control of virus infection, but the specific ISGs and regulatory pathways that restrict West Nile virus (WNV) are not defined.
|
22065572 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Some controversy exists around IL-27 and IFN-α, cytokines possibly released during bacterial or viral infections.
|
26324343 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters.
|
31784575 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-α 2b therapy maybe useful in controlling recalcitrant viral infections in these patients.
|
24743019 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review we focus on the role of IFN-λ at barrier surfaces, focusing on the respiratory and GI tracts, the BBB, and the placenta, and on how these IFNs act to suppress viral infections.
|
30219309 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection.
|
31379819 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferons (IFNs) are secreted glycoproteins that are produced by cells in response to virus infection and other stimuli and induce an antiviral state in cells bearing IFN receptors.
|
29551142 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
SCARB2 or PSGL-1 receptor binding is the first step in the development of viral infections, and viral factors (e.g., 5' UTR, VP1, 3C, 3D, 3' UTR), host factors and environments (e.g., ITAFs, type I IFN) are also involved in viral infections.
|
24602216 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses.
|
28963109 |
2018 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
On further examination, this inability to express natural IFN-alpha appeared to be due to a defect in activation of the IFN-alpha promoters, since constructs containing the IFN-alpha promotor were completely unresponsive to viral infection in melanoma cells but inducible in melanocytes.
|
7664286 |
1995 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Consistently, AIP-deficient murine embryonic fibroblasts are highly resistant to virus infection because of increased production of IFNα/β.
|
25911105 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Induction of Type I Interferon (IFN) genes constitutes an essential step leading to innate immune responses during virus infection.
|
22685561 |
2012 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection.
|
30195710 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type 1 interferon (IFNα/β) has a significant role in establishing protection against virus infections.
|
24793964 |
2014 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Studies with intramuscular injection of IFN expression plasmids have recently provided surprising results, which may be of relevance for application of IFN-I in prophylaxis against virus infection.
|
28196779 |
2018 |