|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Human choriocarcinoma cells (Jar) stably transfected with 1.8 kilobases of promoter from a bovine IFN tau gene ahead of a human GH (hGH) reporter gene constitutively synthesize hGH, but expression is not increased further by exposure to Newcastle disease virus.
|
8052267 |
1994 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
On further examination, this inability to express natural IFN-alpha appeared to be due to a defect in activation of the IFN-alpha promoters, since constructs containing the IFN-alpha promotor were completely unresponsive to viral infection in melanoma cells but inducible in melanocytes.
|
7664286 |
1995 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HLA class I Ag expression, which could be activated by IFN in noninfected A549 and HFL1 cells, was not induced in these cells by virus infection.
|
9036986 |
1997 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that in SIDS a viral infection leads to the release of IFNalpha which could activate a battery of IFN-inducible genes.
|
9864383 |
1999 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The L protein specifically inhibits the transcription of the IFN-alpha4 and IFN-beta genes, which are known to be activated early in response to viral infection.
|
11483724 |
2001 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
While there is only one IFN-beta gene, there are several IFN-alpha genes whose products act through the same receptor calling into question the role of these gene products against viral infection.
|
12323398 |
2002 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Cloning of woodchuck IFNA genes will allow testing diverse forms of IFN-alpha delivery as well as different combination therapies in woodchuck hepatitis virus infection, thus providing useful information for the design of new strategies for the treatment of patients with chronic hepatitis B.
|
12226832 |
2002 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of IFN-lambda mRNAs was inducible by viral infection in several cell lines.
|
12483210 |
2003 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We have previously shown a critical role for IFN regulatory factor 5 (IRF-5) in the innate immune response to virus infection.
|
14559832 |
2003 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We investigated the roles of Toll-like receptor 2 (TLR2) and myeloid differentiation factor 88 (MyD88) in the course of a lymphocytic choriomeningitis virus (LCMV) infection and revealed the following: (i) studies of transfected cells and murine peritoneal macrophages demonstrated that TLR2 and MyD88 are essential for the initial pro-inflammatory cytokine response (human IL-8, mouse IL-6) to LCMV; (ii) TLR2 knockout (KO) mice and MyD88 KO mice challenged with LCMV produced less IL-6 and monocyte chemotactic protein-1 in the serum than wild-type mice; (iii) in contrast to inflammatory cytokines, the production of type 1 IFN (IFN-alpha) in response to LCMV was MyD88 independent; (iv) MyD88 plays an essential role in antiviral CD8(+) T cell responses, CD8(+) T cells in MyD88 KO mice were defective in their expression of intracellular antiviral cytokines; and (v) the failure of MyD88 KO mice to activate CD8(+) T cells was accompanied by persistent viral infection in MyD88 KO mice.
|
15724245 |
2005 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of the antiviral cytokines IFN-alpha/beta is among the most potent innate defenses of higher vertebrates to virus infections, which is controlled by the inducible transcription factor IFN regulatory factor (IRF)3.
|
16155125 |
2005 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Blood cultures were stimulated with different viruses (respiratory syncytial virus (RSV), newcastle disease virus (NDV)) and analysed for IFN-alpha2 protein release and gene transcription.
|
16499644 |
2006 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Viral signaling through retinoic acid-inducible gene-I (RIG-I) and its adaptor protein, IFN promoter-stimulator 1 (IPS-1), activates IFN regulatory factor-3 (IRF-3) and the host IFN-alpha/beta response that limits virus infection.
|
16585524 |
2006 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, viral RNA-induced type I IFN regulates the antigen-processing machinery early during viral infection and prior to IFN-gamma response.
|
18184038 |
2007 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IFN regulatory factor 3 (IRF3) is a transcriptional factor that plays a crucial role in activation of innate immunity and inflammation in response to viral infection, and is also involved in p53-dependent inhibition of cell growth.
|
18056437 |
2007 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These IFN-alphas have an activity profile that may result in an improved therapeutic index and, consequently, better clinical efficacy for the treatment of chronic viral diseases such as hepatitis B virus, human papilloma virus, HIV, or chronic hepatitis C.
|
17494769 |
2007 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Production of type I IFN is the key response to viral infection.
|
17969450 |
2007 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Unique gene modulatory effects, when coupled with the moderate severity of side effects and a potentially central role in innate immunity, provide rationale for further clinical evaluation of IFN-alpha1 in virus infections and cancer.
|
17339865 |
2007 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our results suggest nonredundant, complementary roles of type I zfIFNs in viral infections and provide evidence for a pivotal role of the recently identified group II IFN of fish in the early stages of viral infections.
|
19265122 |
2009 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This is consistent with previous studies showing that IFNAR-mediated protection is redundant for mucosal influenza virus infection and with data showing that the type III IFN receptor is expressed primarily by epithelial cells.
|
20739515 |
2010 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
When compared with C57BL/6 mice, Irf5(-/-) mice show higher susceptibility to viral infection and decreased serum levels of type I IFN and the inflammatory cytokines IL-6 and TNF-alpha.
|
20176957 |
2010 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Successful defense against virus infection relies on early detection by germ line-encoded pattern recognition receptors and activation of cytokine and type I IFN genes.
|
20042593 |
2010 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-β is known to induce a large number of genes that play an important role in regulating responses to viral infection, immune modulation, and cell proliferation.
|
20874251 |
2010 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
During its migration in the nervous system (NS), RABV triggers an innate immune response, including a type I IFN response well known to limit viral infections.
|
21805057 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The actions of IFN-stimulated genes (ISGs) impart control of virus infection, but the specific ISGs and regulatory pathways that restrict West Nile virus (WNV) are not defined.
|
22065572 |
2011 |