|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significantly lower plasma melatonin concentration was found in patients with AD but not in controls, who were noncarriers of the APOE ε4 allele, regardless of the presence of depression or the severity of dementia in AD.
|
29852871 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results supported the hypothesized path model (root mean square error of approximation = 0.041; comparative fit index = 0.959); however, APOE-conferred risk was not a significant moderator of the 2004 or 2011 vascular depression effect and only approached significance as a predictor of depression in 2011 (P = .079).
|
28640987 |
2017 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine if the APOE epsilon4 allele influences response in geriatric depression to mirtazapine and paroxetine, two frequently prescribed antidepressants.
|
14512205 |
2003 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.
|
26785975 |
2016 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the roles of ApoE alleles and genotypes in dementia and cognitively impaired not demented (CIND), assessed the risk of co-existing or prior health conditions (i.e. depression), family history of diseases, and lifestyle factors on dementia, and explored the interactions between genetic and environmental risk factors and their joint effects on dementia and cognitive impairment.
|
23255503 |
2013 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the apolipoprotein E epsilon4 allele with late-onset depression.
|
11684904 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The authors examined the association of Apolipoprotein-E (APO-E) genotype to symptoms of psychosis and depression in 501 patients diagnosed with probable (n=343) or possible (n=158) Alzheimer's disease (AD) according to NINCDS-ADRDA criteria.
|
10322238 |
1999 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ApoE4 allele is associated with late-life depression: a population-based study.
|
17911363 |
2007 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE related hippocampal shape alteration in geriatric depression.
|
19010425 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F = 3.062; p < .05 and F = 3.2670; p < .05, respectively).
|
27113638 |
2017 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The FCs of the rLOD patients without APOE4 were significantly increased (p<0.05) in the resting state, but the rLOD patients who carried APOE4 showed a trend toward decreased FCs.
|
23270974 |
2013 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In cognitively healthy research participants with a first-degree relative with AD, disclosure of APOE ε4-positivity does not lead to elevated anxiety and depression levels, but does increase test-related distress and results in behavior changes concerning insurance and health.
|
27832826 |
2016 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was no interaction between depression and APOE on cognition (p > .05).
|
26035038 |
2015 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype and hippocampal volume change in geriatric depression.
|
11904138 |
2002 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, mean age-of-onset of depression in APOE4 carriers (51.4+/-20.7) was significantly lower than non-carriers (58.8+/-16.8).
|
14677138 |
2003 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Other highly relevant risk factors were activities of daily living (ADL), instrumental ADL, aging, depression, gender, the APOE ε4 allele, and comorbidities (depression as well as gastrointestinal, osteoarticular, and neurodegenerative diseases).
|
27907913 |
2017 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study.
|
18058831 |
2008 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Possessing the APOE epsilon4 allele and depression did not enter either model significantly.
|
11939895 |
2002 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used logistic regression to investigate the association between the combined scores from these two items and cognitive health at follow-up, while adjusting for several health and life-style variables from midlife and for apolipoprotein E4 (ApoE4) status, depression and hopelessness feelings at follow-up.
|
26460971 |
2015 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subanalyses were inconclusive for APOE ɛ4-positive participants, although mean anxiety and depression scores were still well below cutoffs for clinical concern.ConclusionTelephone disclosure of APOE results and risk for Alzheimer disease is generally safe and helps providers meet demands for services, even when results identify an increased risk for disease.
|
28726810 |
2018 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicate a role of APOE genotype in onset of comorbid depression in a subgroup of patients with AD who are not carriers of the APOE ε4 allele.
|
29703883 |
2018 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of 4 genes, methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein E (ApoE) have been demonstrated to associate with the increased risk for both MDD and stroke, while the association between identified polymorphisms in angiotensin converting enzyme (ACE) and serum paraoxonase (PON1) with depression is still under debate, for the existing studies are insufficient in sample size.
|
30898617 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multivariable analyses were adjusted for socio-demographic and vascular factors, cognitive impairment, and apolipoprotein E. Strong significant associations were found between all seven SNPs and DEP and, in particular, first-onset DEP in persons without a past history of depression (P-values ranging from 0.005 to 0.0004).
|
24193727 |
2013 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
No association between the frequency of ApoE-ɛ4 and the occurrence of depression was found in patients undergoing hemodialysis.
|
25707516 |
2015 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In survival analyses, age (hazard ratio [HR] 1.04, 95% 1.03-1.05), baseline Mini-Mental State Exam (HR 0.85, 95% confidence interval 0.83-0.87), amnestic subtype of mild cognitive impairment (HR 1.66, 95% 1.30-2.12), presence of APOE4 allele (HR 1.99, 1.69-2.36), and presence of active depression within the last two years (HR 1.44, 95% confidence interval 1.16-1.79) were all independently associated with increased risk of Alzheimer dementia.
|
29960668 |
2018 |