|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
APOE ε3ε3 was the most frequent genotype, with a frequency of 72.6% in controls, 72.5% in early AMD, and 70.3% in exudative AMD.
|
21541275 |
2011 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated the frequency of Tyr402His polymorphism of the complement factor H (CFH) gene, Ser69Ala polymorphism at LOC387715, rs11200638 polymorphism of the HTRA1 gene and different apolipoprotein E (ApoE) alleles in Hungarian patients with AMD in order to determine the disease risk conferred by these factors.
|
19845562 |
2011 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our expanded analysis substantially improves our understanding of the association between the APOE locus and AMD.
|
21882290 |
2011 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The authors included only the 10,623 control subjects from these studies who were classified as having no evidence of AMD, since variation within the APOE gene has previously been associated with AMD.
|
21498624 |
2011 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
APOE4 carriers may have a reduced risk of intermediate/late AMD (OR = 0.5 [0.3-0.9], P = .015.
|
21906714 |
2011 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Other murine models target genes relevant to AMD, including inflammatory genes such as Cfh(-/-), Ccl2(-/-), Ccr2(-/-), Cx3cr1(-/-), and Ccl2(-/-)/cx3cr1(-/-), oxidative stress associated genes such as Sod1(-/-) and Sod2 knockdown, metabolic pathway genes such as neprilysin(-/-) (amyloid beta), transgenic mcd/mcd (cathepsin D), Cp(-/-)/Heph(-/Y) (ferroxidase ceruloplasmin/hepaestin, iron metabolism), and transgenic ApoE4 on high fat and high cholesterol diet (lipid metabolism).
|
20206286 |
2010 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Since single nucleotide polymorphism (SNP) rs405509:G>T is a constituent of the extended epsilon-haplotype block and is known to significantly influence APOE promoter activity, we hypothesize that both the relative rate of APOE isoform expression in conjunction with established functional differences of the respective isoforms may be crucial in mediating AMD pathology.
|
19384966 |
2009 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found no association between AMD and APOE polymorphism in a population of 96 individuals aged 50-75 years.
|
18498549 |
2008 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
No significant association was observed between neovascular AMD and APOE or ELOVL4.
|
17210851 |
2007 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Consistent with previous studies, the APOE epsilon2 allele is associated with a significant increased risk of late ARM development, whereas the epsilon4 allele may confer some protection.
|
17210854 |
2007 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, susceptibility variants at other loci, several as yet unidentified, make substantial cumulative contribution to genetic risk for AMD; among these, multiple studies support the role of variants in APOE and C2/BF genes.
|
17911160 |
2007 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After controlling for age, gender, race, cigarette smoking, and other factors, early ARM was not associated with APOE genotypes, with an odds ratio (OR) of 1.35 (95% confidence interval [CI], 0.54-3.38) for epsilon2/epsilon2 genotype, an OR of 1.06 (95% CI, 0.80-1.40) for epsilon2/epsilon3 genotype, an OR of 0.63 (95% CI, 0.32-1.24) for epsilon2/epsilon4 genotype, an OR of 0.99 (95% CI, 0.80-1.24) for epsilon3/epsilon4 genotype, and an OR of 0.88 (95% CI, 0.47-1.63) for epsilon4/epsilon4 genotype, as compared with epsilon3/epsilon3 genotype (reference).
|
16406547 |
2006 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD).
|
16453339 |
2006 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
CTD_human |
Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD).
|
16453339 |
2006 |
|
Age related macular degeneration
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This result is at least as important at the population level as ApoE4 and Alzheimer's disease, playing a role in almost 60% of AMD at the population level.
|
16905558 |
2006 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between apolipoprotein E polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis.
|
16916985 |
2006 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation.
|
16823865 |
2006 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis of CFH, TLR4, and APOE polymorphism in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration.
|
16936080 |
2006 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the effect of TLR4, APOE and ABCA1 variants on AMD susceptibility was opposite to that of association with atherosclerosis risk.
|
15829498 |
2005 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
The results show that APOE effects may be mediated early in the progression of ARM to AMD and thus may not be detected by standard genome scans for more severe disease.
|
16123405 |
2005 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate whether APOE genotypes modify the smoking-associated risk of AMD.
|
16288198 |
2005 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We describe here a murine model that combines three known AMD risk factors: advanced age, high fat cholesterol-rich (HF-C) diet, and apolipoprotein E (apoE) genotype.
|
16079201 |
2005 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center.
|
15111581 |
2004 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
How distinct APOE alleles affect AMD susceptibility warrants further investigation.
|
15111581 |
2004 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To date, of all the genes studied in relation to age-related macular degeneration (AMD), the alleles of the apolipoprotein (apoE) gene have been the most consistently associated with disease.
|
15111582 |
2004 |