|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, MS quiescence appears to correlate with restoration of suppressive function in memory-derived CD4(+)CD25(-)FOXP3(-) iTregs.
|
27154631 |
2016 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.
|
26765264 |
2016 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We show that an MS-associated polymorphism in the IL-2 receptor alpha (IL2RA) gene specifically increases the frequency of GM-CSF-producing TH cells.
|
25278028 |
2014 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Insight into the associations of MS-associated <i>IL2RA</i> SNPs, as these new findings provide, offers a better understanding of CD25 variation in the immune system and can lead to new insights into how MS-associated SNPs contribute to development of MS.
|
31242590 |
2019 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells.
|
15788534 |
2005 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide study showed three additional single-nucleotide polymorphisms (SNPs), within the IL2RA and IL7RA genes respectively, also to be associated with MS.
|
18401352 |
2008 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphism (rs1800693) of TNFRSF1A (type 1 tumour necrosis factor receptor) encodes a potentially anti-inflammatory soluble truncated form of the p55 receptor, which is associated with predisposition to multiple sclerosis but protection against ankylosing spondylitis (AS).
|
29535371 |
2019 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
|
19525955 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The proposed procedure is illustrated on a multiple sclerosis (MS) family data set including genotypes of SNPs in IL2RA, confirming the advantage of using a family design to identify causal variants.
|
25585700 |
2015 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Blockage of CD25, among other effects, causes expansion and enhanced function of regulatory CD56<sup>bright</sup> natural killer cells, which seems to be the leading mechanism of action in MS.
|
28450896 |
2017 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Further characterization of the effect of IL2RA and IL7R genetic variants in defined MS subtypes is warranted to evaluate the effect of these genes on specific clinical outcomes and to further elucidate the mechanisms of disease onset and progression.
|
24770783 |
2014 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that, in addition to specific allelic variants at IL2RA, immunological perturbations associated with aggressive forms of the disease can influence sIL-2RA levels in serum of MS subjects.
|
19155502 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide polymorphisms (SNPs) within this gene with type 1 diabetes mellitus (DM), Graves' disease, rheumatoid arthritis (RA), and multiple sclerosis (MS).
|
19116909 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings confirm and extend the association of this gene with MS and reveal a genetic heterogeneity of the associated polymorphisms and risk alleles between MS and T1D suggesting different immunopathological roles of IL2RA in these two diseases.
|
19125193 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Daclizumab is a humanized monoclonal IgG1 antibody that binds to CD25 that has been studied for the treatment of multiple sclerosis (MS).
|
30885425 |
2019 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians.
|
18650830 |
2008 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recently, large international collaborations provided strong evidence for the involvement of polymorphism of two cytokine receptor genes in the pathogenesis of MS: the interleukin 7 receptor alpha chain gene (IL7RA) on chromosome 5p13 and the interleukin 2 receptor alpha chain gene (IL2RA (=CD25)) on chromosome 10p15.
|
18461312 |
2008 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Overexpression of the Cytokine BAFF and Autoimmunity Risk.
|
28445677 |
2017 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
|
19525955 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
For example, nucleotide variation in the interleukin 7 receptor (IL7RA), the interleukin 2 receptor (IL2RA), the CD58 and the c-type lectin domain family 16 member A (CLEC16A) genes has been consistently associated with MS in several populations.
|
20450971 |
2010 |