|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chronic HFD-induced obesity is associated with hepatic IL-6 resistance due to saturated FA-induced ER stress.
|
31085628 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
RGD |
Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets.
|
21826222 |
2011 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that obesity promotes CNS inflammation in EAE through IL-6 and CCL-2 mediated the inflammatory cells infiltration.
|
31507583 |
2019 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Common variants of IL6, LEPR, and PBEF1 are associated with obesity in Indian children.
|
22228719 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The presence of obesity at ≥ 2 follow-ups showed the highest mean values (SE) for IL-6 [2.45 (1.05)] and CRP [3.74 (1.11)] and the lowest mean value for adiponectin [8.60 (0.37)] (adjusted analyses, females) compared with other exposures; the highest mean of IL-6 [1.65 (1.05)] and CRP [1.78 (1.11)] and the lowest mean of adiponectin [9.98 (0.38)] were for the number of follow-ups with ≥2 exposures compared to those with no exposures at any follow-up (adjusted analyses, females).
|
31071114 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-6 (IL-6) is systemically elevated in obesity and is a predictive factor to develop type 2 diabetes.
|
18719127 |
2008 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The IL-6 G174C polymorphism was also associated obesity when using allelic comparisons, the recessive genetic model and the dominant genetic model with OR (95% CI) of 1.95 (1.37-2.77), 1.44 (1.15-1.80), and 1.36 (1.16-1.59), respectively.
|
21660081 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that body weight loss upregulates the expression of Mfn2 mRNA in skeletal muscle of obese humans, type 2 diabetes downregulates the expression of Mfn2 mRNA in skeletal muscle, Mfn2 expression in skeletal muscle is directly proportional to insulin sensitivity and is inversely proportional to the BMI, TNFalpha and interleukin-6 downregulate Mfn2 expression and may participate in the dysregulation of Mfn2 expression in obesity or type 2 diabetes, and the in vivo modulation of Mfn2 mRNA levels is an additional level of regulation for the control of muscle metabolism and could provide a molecular mechanism for alterations in mitochondrial function in obesity or type 2 diabetes.
|
16123358 |
2005 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found that IL-1B rs1864169 and IL-6 rs1800796 polymorphisms may interact with diabetes, hypertension and obesity.
|
24782217 |
2014 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between -174G>C polymorphism in the IL-6 promoter region and the risk of obesity: A meta-analysis.
|
30113463 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNFalpha) are produced by human adipose tissue dependent on the degree of obesity.
|
20660075 |
2010 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The most appropriate prognostic indexes and associations were for hs-CRP, IL-6, and Hcy with abdominal obesity, waist circumference, WHtR, and wrist circumference, respectively.
|
30584444 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Visceral white adipose tissue (WAT) has been closely associated with obesity-induced inflammation and adipose tissue macrophages (ATMs) are responsible for obesity-induced inflammation by releasing inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6.
|
28985514 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition to the interference of artemisinic acid with adipogenesis, artemisinic acid significantly attenuated tumor necrosis factor-α-induced secretion of interleukin-6 by undifferentiated hAMSCs, thus influencing insulin resistance and the inflammatory state characterizing obesity.
|
22396222 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Additionally, mediation effects of high-sensitive C-reactive protein and interleukin-6 (IL6) measured in blood were related to obesity and WMH using linear regression and structural equation models.
|
30556596 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In one murine BC model, obesity was associated with increased IL-6 production from adipocytes and myeloid cells within tumors.
|
29540614 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
The chronic inflammatory response caused by obesity and enhanced production of IL-6 and TNF may also increase the risk of other cancers.
|
20141834 |
2010 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity is per se associated with increased adipose expression and plasma levels of leptin, lower expression of adiponectin, and marginally elevated expression of IL-6, but PCOS does not appear to have an independent effect on the adipose expression of leptin, adiponectin, and IL-6 or the circulating adipocytokines.
|
22607892 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The data showed that BM-MSCs from Mutant demonstrated a state of disease memory, depicted by an upregulated expression of inflammatory markers (IL-6, TNFα); increased stem cell recruitment (Oct-4, Sox-2) and proliferation rates (CD90+/CD29+, PDA, 'S' phase of cell cycle by FACS and BrdU incorporation); accelerated preadipocyte induction (Dact-1, PPARγ2) with a quantitative increase in mature adipocyte formation (Leptin); ILCAs, which were non-responsive to high glucose did confer the Obese/T2D memory in Mutants.
|
23144726 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity in patients was associated with a marked increase in IL-6 and CRP levels.
|
28103807 |
2017 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In G/G population, the IL-6 plasma level of NWO and OB was significantly higher with respect to NW.
|
18991689 |
2008 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism found in point 174 (G174C) of a promoter region of IL-6 gene affects the level of interleukin-6 expression and, consequently, may lead to obesity and correlated conditions.
|
21147639 |
2010 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The tumor-infiltrating CD11b-positive cell count was significantly higher in prostatectomy specimens of obese than those of nonobese patients with prostate cancer.<b>Conclusions:</b> HFD increased MDSCs and accelerated prostate cancer tumor growth via IL6/pSTAT3 signaling in the mice.
|
29776955 |
2018 |
|
Obesity
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Interleukin-6 CpG Methylation and Body Weight Correlate Differently in Type 2 Diabetes Patients Compared to Obese and Lean Controls.
|
26067576 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adoptive transfer experiments of cytokine-deficient mast cells show that these cells, by producing interleukin-6 (IL-6) and interferon-gamma (IFN-gamma), contribute to mouse adipose tissue cysteine protease cathepsin expression, apoptosis and angiogenesis, thereby promoting diet-induced obesity and glucose intolerance.
|
19633655 |
2009 |