|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In contrast to TNF, plasma (rather than adipose) IL-6 demonstrated the strongest relationship with obesity and insulin resistance.
|
11287357 |
2001 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
It has been proposed that the secretion of interleukin-6 (IL-6) by adipose tissue, combined with the actions of adipose tissue-expressed TNF-alpha in obesity, could underlie the association of insulin resistance with endothelial dysfunction, coagulopathy, and coronary heart disease.
|
12508953 |
2002 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A promoter polymorphism in the IL6 gene is associated with obesity, altered levels of insulin sensitivity, and T2DM.
|
14680981 |
2003 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that genetic variation in or near the IL6 locus may be involved in the etiology of obesity and osteoporosis.
|
12898289 |
2003 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, these data suggest that endogenous IL-6 has antiobesity effects and, therefore, it is possible that low endogenous IL-6 production contributes to obesity in humans.
|
14519071 |
2003 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results are in agreement with the hypothesis that the synthesis of adipose tissue TNFalpha and leptin could induce the production of interleukin-6, CRP, and other acute-phase reactants, thus contributing to the maintenance of chronic low-grade inflammation state involved in the progression of obesity and its associated comorbidities.
|
12690081 |
2003 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-6 (IL-6), is an inflammatory cytokine that may influence the pathogenesis of obesity and hyperandrogenism.
|
12917504 |
2003 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The interleukin 6-174G/C polymorphism is associated with indices of obesity in men.
|
12560873 |
2003 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Multivariate linear regression analysis revealed that obesity is the dominant force, thus explaining 18% and 24% of the IL-6 or CRP levels, respectively, in PCOS women.
|
15080783 |
2004 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In view of the increase in plasma concentrations of proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP) in obesity, we investigated whether peripheral blood mononuclear cells (MNC) from obese subjects are in a proinflammatory state.
|
15364812 |
2004 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity.
|
15561970 |
2004 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
From the results of the present study, we concluded that individuals homozygous for G allele on the IL-6 gene have higher values in some parameters associated with obesity.
|
15292466 |
2004 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Circulating levels of interleukin-6 (IL-6) are raised in insulin resistant states such as obesity, impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM).
|
15172007 |
2004 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of IL-6 add further risk to the impact of obesity in respect to the development of type 2 diabetes mellitus (T2DM).
|
15070960 |
2004 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that body weight loss upregulates the expression of Mfn2 mRNA in skeletal muscle of obese humans, type 2 diabetes downregulates the expression of Mfn2 mRNA in skeletal muscle, Mfn2 expression in skeletal muscle is directly proportional to insulin sensitivity and is inversely proportional to the BMI, TNFalpha and interleukin-6 downregulate Mfn2 expression and may participate in the dysregulation of Mfn2 expression in obesity or type 2 diabetes, and the in vivo modulation of Mfn2 mRNA levels is an additional level of regulation for the control of muscle metabolism and could provide a molecular mechanism for alterations in mitochondrial function in obesity or type 2 diabetes.
|
16123358 |
2005 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Indeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8 +/- 2.3 vs 24.14 +/- 1.9; f = 5.31; p < 0.005), insulin resistance (1.49 +/- 0.70 vs 2.13 +/- 0.92; f = 4.342; p = 0.038) and triglyceride levels (79.15 +/- 32.9 vs 98 +/- 6.73 mg/dl; f = 3.120; p < 0.005).
|
16029943 |
2005 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Composite genotype or haplotype analyses of all 3 IL6 promoter variants showed associations with type 2 diabetes (p<0.002), obesity (p<0.02), and the metabolic syndrome (p<0.01).
|
15645209 |
2005 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The evolutive advantages of increased inflammatory responses, hypersecretion of proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and IL-18], or decreased anti-inflammatory molecules (adiponectin, certain TNF-alpha isoforms, soluble CD14, etc.), would lead in westernized countries to chronic inflammation conditions, such as obesity and type 2 diabetes, resulting in cardiovascular disease.
|
16472051 |
2006 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The -174 IL-6 promoter polymorphism modifies the association of obesity with IR and diabetes risk in men.
|
16988089 |
2006 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recalled weight change from age 25 years to study enrollment differed significantly according to genotype (p = 0.044) and was most pronounced in subjects with the CC genotype, suggesting that the IL-6 g.-174G>C promoter polymorphism is a susceptibility or modifying locus for common obesity and weight gain.
|
16493118 |
2006 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In adults, markers of subclinical inflammation (C-reactive protein [CRP] and interleukin [IL]-6) and endothelial activation (intracellular adhesion molecule [ICAM]-1) are associated with obesity and higher risk for incident type 2 diabetes.
|
17704300 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-6 (IL-6) is systemically elevated in obesity and is a predictive factor to develop type 2 diabetes.
|
18719127 |
2008 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In G/G population, the IL-6 plasma level of NWO and OB was significantly higher with respect to NW.
|
18991689 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
During the expansion of adipose tissue mass in obesity there is a major inflammatory response in the tissue with increased expression and release of inflammation-related adipokines, including IL-6, leptin, monocyte chemoattractant protein-1 and TNF-alpha, together with decreased adiponectin production.
|
18397542 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In patients with chronic HCV, obesity and steatosis are associated with increased expression of selected inflammatory markers; however, circulating levels of IL-6 and TNF-alpha do not reflect hepatic expression.
|
18571785 |
2008 |